DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15056 and CG14891

DIOPT Version :9

Sequence 1:	NP_573291.1	Gene:	CG15056 / 32824	FlyBaseID:	FBgn0030918	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_650560.1	Gene:	CG14891 / 42013	FlyBaseID:	FBgn0038445	Length:	495	Species:	Drosophila melanogaster

Alignment Length:	374	Identity:	124/374 - (33%)
Similarity:	202/374 - (54%)	Gaps:	18/374 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 DFFWLDVLKQLDLKSRISFAASCDMFENIYVRSSPLRLSRVVNLEEMIEFSLLETKLFVELSGSD 77
            |..|..||..|.|..|::|||||:.|:.||...|. |::.|:|::::...:....|..:.|||..
  Fly   118 DDIWWKVLDYLSLNERLNFAASCERFQAIYELDSH-RINHVLNMKDVCTLTHRVIKRLMLLSGKH 181

  Fly    78 IEIIRGGPHTPMFSHFEDFIRLMSIRLTKVNEIALEGFQLT-----QYKWFNAPETSFSNLTYVS 137
            |..:.|||..|.:.:..:|::|:.:....:.|::.  |:::     ....|:. .....|:|.:|
  Fly   182 IHCVTGGPLHPNWPYLTEFVQLLGVSCPNLTELSF--FKISVSLAHMTHLFDG-ANGLINITNIS 243

  Fly   138 LRRCQLNDENLVGWEFLTHLETLDLRYNDRLTGSCLMSLPTSLLSLYITGCRNLCPNQLIFLNRI 202
            ||||.|.|.::...:.|:.|::||:|.|..:.|..|.|||.||..|.::||.:|.|..||.|..:
  Fly   244 LRRCNLKDAHIYCLQMLSKLKSLDIRENFSIKGDSLKSLPISLEILNVSGCVDLSPKCLIQLAAL 308

  Fly   203 PRLRELRASDLMP-GGHWHIYRDLVLACPLLVMVEISICSLNRDEYRLGELRYLQSLVIKAHSTD 266
            ..|||||...::. .....:|..|...||:|.::|::..   .:..:||.|..|.:|||  ||:.
  Fly   309 SHLRELRCPGIVKFAKDNELYGRLAHYCPMLEVLELTDF---MNVIQLGGLSRLHTLVI--HSSA 368

  Fly   267 TIRCKVSDWMLISLLDVPFLRNLMFSDA--PSGFVSANALSIISRFRQLRVLKMPNQPYRPNDLL 329
            .:...|::.:|.|:.:...||:|...|:  |....|.: |||.|:.::||.|.:.||.:....|:
  Fly   369 QLDYHVNNVLLTSIAESYSLRHLEILDSFGPMSDTSFD-LSIFSQLKELRTLILHNQNFTTLHLM 432

  Fly   330 RLRNLTFLETLDLSNSPYITNEVVIELVIGIPNLSVLIVQGCPLLTNRV 378
            .|:.|:.||.||||.||.::||||.:|...:..|..|.|..|||:|.::
  Fly   433 GLQKLSTLEFLDLSGSPNLSNEVVAKLTKSLSGLRRLKVDFCPLITRQL 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15056	NP_573291.1	leucine-rich repeat	133..156	CDD:275381	9/22 (41%)
		leucine-rich repeat	157..179	CDD:275381	10/21 (48%)
		leucine-rich repeat	180..204	CDD:275381	9/23 (39%)
		leucine-rich repeat	205..231	CDD:275381	8/26 (31%)
		leucine-rich repeat	232..285	CDD:275381	14/52 (27%)
		leucine-rich repeat	286..326	CDD:275381	15/41 (37%)
		AMN1	306..>376	CDD:187754	29/69 (42%)
		leucine-rich repeat	337..362	CDD:275381	13/24 (54%)
CG14891	NP_650560.1	RRM_6	25..91	CDD:290958
		AMN1	<199..352	CDD:187754	46/158 (29%)
		leucine-rich repeat	211..237	CDD:275381	3/28 (11%)
		leucine-rich repeat	239..262	CDD:275381	9/22 (41%)
		leucine-rich repeat	263..285	CDD:275381	10/21 (48%)
		leucine-rich repeat	286..338	CDD:275381	17/51 (33%)
		leucine-rich repeat	339..387	CDD:275381	14/52 (27%)
		leucine-rich repeat	388..415	CDD:275381	10/27 (37%)
		leucine-rich repeat	416..439	CDD:275381	8/22 (36%)
		leucine-rich repeat	440..465	CDD:275381	13/24 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457996
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0019540
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.740