DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15056 and fbxl2

DIOPT Version :9

Sequence 1:	NP_573291.1	Gene:	CG15056 / 32824	FlyBaseID:	FBgn0030918	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_956400.1	Gene:	fbxl2 / 378737	ZFINID:	ZDB-GENE-030925-12	Length:	432	Species:	Danio rerio

Alignment Length:	309	Identity:	68/309 - (22%)
Similarity:	116/309 - (37%)	Gaps:	88/309 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 FIRLMSIR-LTKVNEIALEGF----QLTQYKWFNAPETSFSNLTYVSLRR-C-QLNDENLVGWEF 153
            |:|.:|:| ...|.:.:::.|    :..::...|.. |..::.|.:||.: | :|...:|.....
Zfish    88 FLRQLSLRGCLSVGDASMKTFAQNCRNIEHLNLNGC-TKITDSTCISLSKFCFKLRHLDLTSCVS 151

  Fly   154 LTH------------LETLDLRYNDRLTGSCLMSLP---TSLLSLYITGCRNLCPNQLIFLNR-I 202
            :|:            ||.|:|.:.|::|...:.:|.   |:|.:|::.||..|....|..|.: .
Zfish   152 ITNHALKALSEGCRMLENLNLSWCDQITSDGIEALSRGCTALRALFLRGCTQLDDTALKHLQKHC 216

  Fly   203 PRLRELR---ASDLMPGGHWHIYRDLVLACPLLVMVEISICSLNRDEYRLGELRY-LQSLVIKAH 263
            |.|..:.   .:.:...|    :..|...|..|.||.||.|| |..:..|..|.. .|.|.|
Zfish   217 PELMTINMQSCTQITDDG----FVSLCRGCHKLQMVCISGCS-NITDASLTALGLNCQRLKI--- 273

  Fly   264 STDTIRCK-VSDWMLISLLDVPFLRNLMFSDAPSGFVSANALSIISRFRQLRVLKMPNQPYRPND 327
             .:..||. |:|                     :||.
Zfish   274 -LEAARCSHVTD---------------------AGFT---------------------------- 288

  Fly   328 LLRLRNLTFLETLDLSNSPYITNEVVIELVIGIPNLSVLIVQGCPLLTN 376
             :..||...:|.:||.....:|:..:::|.|..|.|..|.:..|.|:|:
Zfish   289 -VLARNCHEMEKMDLEECILVTDNTLVQLSIHCPRLQALSLSHCELITD 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15056	NP_573291.1	leucine-rich repeat	133..156	CDD:275381	6/24 (25%)
		leucine-rich repeat	157..179	CDD:275381	7/24 (29%)
		leucine-rich repeat	180..204	CDD:275381	7/24 (29%)
		leucine-rich repeat	205..231	CDD:275381	4/28 (14%)
		leucine-rich repeat	232..285	CDD:275381	17/54 (31%)
		leucine-rich repeat	286..326	CDD:275381	2/39 (5%)
		AMN1	306..>376	CDD:187754	13/69 (19%)
		leucine-rich repeat	337..362	CDD:275381	6/24 (25%)
fbxl2	NP_956400.1	F-box-like	24..66	CDD:289689
		leucine-rich repeat	61..88	CDD:275381	68/309 (22%)
		AMN1	63..284	CDD:187754	51/205 (25%)
		leucine-rich repeat	89..108	CDD:275381	4/18 (22%)
		leucine-rich repeat	115..140	CDD:275381	6/25 (24%)
		leucine-rich repeat	141..166	CDD:275381	3/24 (13%)
		leucine-rich repeat	167..192	CDD:275381	7/24 (29%)
		leucine-rich repeat	193..218	CDD:275381	7/24 (29%)
		AMN1	212..390	CDD:187754	39/184 (21%)
		leucine-rich repeat	219..244	CDD:275381	4/28 (14%)
		leucine-rich repeat	245..270	CDD:275381	10/25 (40%)
		leucine-rich repeat	271..296	CDD:275381	10/78 (13%)
		leucine-rich repeat	297..322	CDD:275381	6/24 (25%)
		leucine-rich repeat	323..351	CDD:275381	5/14 (36%)
		leucine-rich repeat	352..376	CDD:275381
		leucine-rich repeat	377..402	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588069
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930