DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15056 and fbxl14b

DIOPT Version :9

Sequence 1:	NP_573291.1	Gene:	CG15056 / 32824	FlyBaseID:	FBgn0030918	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001015043.1	Gene:	fbxl14b / 324835	ZFINID:	ZDB-GENE-030131-3556	Length:	400	Species:	Danio rerio

Alignment Length:	340	Identity:	78/340 - (22%)
Similarity:	125/340 - (36%)	Gaps:	98/340 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 RVVNL---EEMIEFSL------LETKLFVELSG------SDIEIIRGGPHTPMFSHFEDFIRLMS 101
            ||:||   :::.:.||      |:....:||.|      :.:.:|..|.|           ||.|
Zfish   120 RVLNLSLCKQITDSSLGRIAQYLKNLEVLELGGCSNITNTGLLLIAWGLH-----------RLKS 173

  Fly   102 IRLTKVNEIALEGFQLTQYKWFNAPETSFSNLTYVSLRRCQ-LNDENL----VGWEFLTHLETLD 161
            :.|.....::..|.........:|.|...| |.|::|:.|| |.|.:|    .|   ||.|:.|:
Zfish   174 LNLRSCRHVSDVGIGHLAGMTRSAAEGCLS-LEYLTLQDCQKLTDLSLKHISKG---LTKLKVLN 234

  Fly   162 LRYNDRLT--GSCLMSLPTSLLSLYITGCRNLCPNQLIFLNRIPRLRELRASDLMPGGHWHIYRD 224
            |.:...::  |...:|..|||.||.:..|.|:....::.|    .:..||.|.|
Zfish   235 LSFCGGISDAGMIHLSHMTSLWSLNLRSCDNISDTGIMHL----AMGTLRLSGL----------- 284

  Fly   225 LVLACPLLVMVEISICSLNRDEYRLGELRYLQSLVIKAHSTDTIRCKVSDWMLISLLDVPFLRNL 289
                       ::|.|....|:    .|.|:...:.:..|.....|.:||
Zfish   285 -----------DVSFCDKIGDQ----SLAYIAQGLYQLKSLSLCSCHISD--------------- 319

  Fly   290 MFSDAPSGFVSANALSIISRFRQLRVLKMPNQPYRPNDL---LRLRNLTFLETLDLSNSPYITNE 351
               |..:        .::.:..:||.|.: .|..|..|.   |...:||.|..:||.....||..
Zfish   320 ---DGIN--------RMVRQMHELRTLNI-GQCVRITDKGLELIADHLTQLTGIDLYGCTKITKR 372

  Fly   352 VVIELVIGIPNLSVL 366
             .:|.:..:|.|.||
Zfish   373 -GLERITQLPCLKVL 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15056	NP_573291.1	leucine-rich repeat	133..156	CDD:275381	10/27 (37%)
		leucine-rich repeat	157..179	CDD:275381	5/23 (22%)
		leucine-rich repeat	180..204	CDD:275381	6/23 (26%)
		leucine-rich repeat	205..231	CDD:275381	4/25 (16%)
		leucine-rich repeat	232..285	CDD:275381	9/52 (17%)
		leucine-rich repeat	286..326	CDD:275381	6/39 (15%)
		AMN1	306..>376	CDD:187754	19/64 (30%)
		leucine-rich repeat	337..362	CDD:275381	6/24 (25%)
fbxl14b	NP_001015043.1	F-box-like	5..46	CDD:403981
		AMN1	90..296	CDD:187754	52/220 (24%)
		leucine-rich repeat	92..118	CDD:275381
		leucine-rich repeat	119..144	CDD:275381	7/23 (30%)
		leucine-rich repeat	145..170	CDD:275381	6/35 (17%)
		leucine-rich repeat	171..203	CDD:275381	6/31 (19%)
		leucine-rich repeat	204..229	CDD:275381	10/27 (37%)
		AMN1	230..388	CDD:187754	46/215 (21%)
		leucine-rich repeat	230..254	CDD:275381	5/23 (22%)
		leucine-rich repeat	255..280	CDD:275381	6/28 (21%)
		leucine-rich repeat	281..304	CDD:275381	7/48 (15%)
		leucine-rich repeat	307..331	CDD:275381	5/49 (10%)
		leucine-rich repeat	332..357	CDD:275381	8/25 (32%)
		leucine-rich repeat	358..382	CDD:275381	6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820