DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15056 and FBXL4

DIOPT Version :9

Sequence 1:	NP_573291.1	Gene:	CG15056 / 32824	FlyBaseID:	FBgn0030918	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001265645.1	Gene:	FBXL4 / 26235	HGNCID:	13601	Length:	621	Species:	Homo sapiens

Alignment Length:	426	Identity:	87/426 - (20%)
Similarity:	156/426 - (36%)	Gaps:	121/426 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 VRSSPLRLSRVVNLE-EMIEFSLLETKLFVELSGSDIE---------IIRGGPHTPMFSHFE-DF 96
            |:..|     |::|: .:|:.:.:|...:.|..|..::         ::..||:...|.... :.
Human   228 VKDKP-----VLSLKTSLIDMNDIEDDAYAEKDGCGMDSLNKKFSSAVLGEGPNNGYFDKLPYEL 287

  Fly    97 IRLMSIRLT----------------------------------KVNEIALEGFQ--LTQYKWFNA 125
            |:|:...||                                  |:::.:||..|  .|..:|.|.
Human   288 IQLILNHLTLPDLCRLAQTCKLLSQHCCDPLQYIHLNLQPYWAKLDDTSLEFLQSRCTLVQWLNL 352

  Fly   126 PETSFSNLTYVSLRRCQLNDENLVGW-EFL----THLETLDLRYNDRLTGSCL---MSLPTSLLS 182
            ..|  .|..::|          :.|: .||    :.|..|:|..:..|..:||   ..:..:|.:
Human   353 SWT--GNRGFIS----------VAGFSRFLKVCGSELVRLELSCSHFLNETCLEVISEMCPNLQA 405

  Fly   183 LYITGCRNLCPNQLIFLNRIPRLRELRASDLMPGGHWHIYRDLVLACPLLVMVEISICSLNRDEY 247
            |.::.|..|.|..   .|.|.:|..|:...|        ||..|....||.:  ::.||
Human   406 LNLSSCDKLPPQA---FNHIAKLCSLKRLVL--------YRTKVEQTALLSI--LNFCS------ 451

  Fly   248 RLGELRYLQ--SLVI----------------KAHSTDTIRCK-VSDWMLISLLD-VPFLRNLMFS 292
               ||::|.  |.|:                |..:.|..||| :::..:..|.. .|.|..|...
Human   452 ---ELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDLG 513

  Fly   293 DAPSGFVSANALSIISRFRQL----RVLKMPNQPYRPNDLLRLR-NLTFLETLDLSNSPYITNEV 352
            ..|:...|....:.::  .||    ::....|:.....|:..|. |.|.|:.||:..:..::...
Human   514 WCPTLQSSTGCFTRLA--HQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDILGTRMVSPAS 576

  Fly   353 VIELVIGIPNLSVLIVQGCPLLTNRVYLDAELASKK 388
            :.:|:....:||:|.|..|..:.||..|:...:..|
Human   577 LRKLLESCKDLSLLDVSFCSQIDNRAVLELNASFPK 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15056	NP_573291.1	leucine-rich repeat	133..156	CDD:275381	4/27 (15%)
		leucine-rich repeat	157..179	CDD:275381	6/24 (25%)
		leucine-rich repeat	180..204	CDD:275381	7/23 (30%)
		leucine-rich repeat	205..231	CDD:275381	6/25 (24%)
		leucine-rich repeat	232..285	CDD:275381	14/72 (19%)
		leucine-rich repeat	286..326	CDD:275381	7/43 (16%)
		AMN1	306..>376	CDD:187754	16/74 (22%)
		leucine-rich repeat	337..362	CDD:275381	4/24 (17%)
FBXL4	NP_001265645.1	F-box-like	280..318	CDD:315592	5/37 (14%)
		leucine-rich repeat	295..317	CDD:275381	2/21 (10%)
		leucine-rich repeat	318..346	CDD:275381	4/27 (15%)
		leucine-rich repeat	347..376	CDD:275381	8/40 (20%)
		LRR 1	376..397		6/20 (30%)
		leucine-rich repeat	377..398	CDD:275381	6/20 (30%)
		AMN1	394..601	CDD:332986	49/230 (21%)
		LRR 2	402..421		5/21 (24%)
		leucine-rich repeat	403..427	CDD:275381	8/26 (31%)
		LRR 3	427..448		7/30 (23%)
		leucine-rich repeat	428..452	CDD:275381	9/42 (21%)
		LRR 4	452..474		5/21 (24%)
		leucine-rich repeat	453..480	CDD:275381	4/26 (15%)
		LRR 5	480..501		5/20 (25%)
		leucine-rich repeat	481..506	CDD:275381	5/24 (21%)
		LRR 6	504..524		5/19 (26%)
		leucine-rich repeat	507..534	CDD:275381	6/28 (21%)
		LRR 7	532..558		4/25 (16%)
		leucine-rich repeat	535..560	CDD:275381	4/24 (17%)
		LRR 8	559..583		5/23 (22%)
		leucine-rich repeat	561..586	CDD:275381	4/24 (17%)
		LRR 9	584..609		8/24 (33%)
		leucine-rich repeat	587..612	CDD:275381	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900