DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG15056 and FBXL7

DIOPT Version :9

Sequence 1:NP_573291.1 Gene:CG15056 / 32824 FlyBaseID:FBgn0030918 Length:399 Species:Drosophila melanogaster
Sequence 2:NP_036436.1 Gene:FBXL7 / 23194 HGNCID:13604 Length:491 Species:Homo sapiens


Alignment Length:291 Identity:69/291 - (23%)
Similarity:111/291 - (38%) Gaps:86/291 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 LETLDLRYNDRLTGSCLMSLPTSLLSLYITGCRNLCPNQLIFLNR-IPRLRELRASDLMPGGHWH 220
            |:.|..|........|||     |.::.::|||.|....|..:.: .|.||.|..|     |.::
Human   170 LKVLTRRLCQDTPNVCLM-----LETVTVSGCRRLTDRGLYTIAQCCPELRRLEVS-----GCYN 224

  Fly   221 IYR----DLVLACPLLVMVEISIC------SLNRD-EYRLGEL-------RYLQSL--------- 258
            |..    |:|..||.|..:::|.|      ||.|: ..:|..|       |||...         
Human   225 ISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEG 289

  Fly   259 --VIKAHSTDTI-----RC-KVSD----WMLISLLDVPFLRNLMFSDAPSGFVSANALSIISRFR 311
              .|.||.|...     || :::|    :::|....:   :.|..||.  .|||...|..|::..
Human   290 LHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASI---KELSVSDC--RFVSDFGLREIAKLE 349

  Fly   312 -QLRVLKMPNQPYRPNDL-----------LR------------------LRNLTFLETLDLSNSP 346
             :||.|.:.:.. |..|:           ||                  .:|.|.|::||:...|
Human   350 SRLRYLSIAHCG-RVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCP 413

  Fly   347 YITNEVVIELVIGIPNLSVLIVQGCPLLTNR 377
            .:::..:..|.:...||..|.::.|..:|.:
Human   414 LVSDTGLECLALNCFNLKRLSLKSCESITGQ 444

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG15056NP_573291.1 leucine-rich repeat 133..156 CDD:275381
leucine-rich repeat 157..179 CDD:275381 6/21 (29%)
leucine-rich repeat 180..204 CDD:275381 6/24 (25%)
leucine-rich repeat 205..231 CDD:275381 9/29 (31%)
leucine-rich repeat 232..285 CDD:275381 19/87 (22%)
leucine-rich repeat 286..326 CDD:275381 12/40 (30%)
AMN1 306..>376 CDD:187754 19/99 (19%)
leucine-rich repeat 337..362 CDD:275381 5/24 (21%)
FBXL7NP_036436.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..79
F-box-like 114..157 CDD:372399
leucine-rich repeat 129..151 CDD:275381
leucine-rich repeat 154..187 CDD:275381 4/16 (25%)
LRR 1 170..195 7/29 (24%)
AMN1 <185..366 CDD:187754 51/196 (26%)
leucine-rich repeat 188..213 CDD:275381 6/24 (25%)
LRR 2 196..221 9/29 (31%)
leucine-rich repeat 214..234 CDD:275381 7/24 (29%)
LRR 3 222..247 6/24 (25%)
leucine-rich repeat 240..273 CDD:275381 8/32 (25%)
LRR 4 253..281 8/27 (30%)
leucine-rich repeat 274..299 CDD:275381 6/24 (25%)
LRR 5 282..307 4/24 (17%)
AMN1 297..464 CDD:187754 32/154 (21%)
leucine-rich repeat 300..325 CDD:275381 4/24 (17%)
LRR 6 308..333 4/27 (15%)
leucine-rich repeat 326..351 CDD:275381 8/29 (28%)
LRR 7 334..359 8/26 (31%)
leucine-rich repeat 352..377 CDD:275381 5/25 (20%)
LRR 8 360..385 4/25 (16%)
leucine-rich repeat 378..403 CDD:275381 3/24 (13%)
LRR 9 386..411 5/24 (21%)
leucine-rich repeat 404..429 CDD:275381 5/24 (21%)
LRR 10 412..437 5/24 (21%)
leucine-rich repeat 430..453 CDD:275381 4/15 (27%)
LRR 11 438..463 2/7 (29%)
leucine-rich repeat 456..480 CDD:275381
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165153069
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.830

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