Protein Alignment CG15056 and KDM2A

DIOPT Version :9

• Sequence 1: NP_573291.1
• Gene: CG15056 / 32824
• FlyBaseID: FBgn0030918
• Length: 399
• Species: Drosophila melanogaster
• Sequence 2: NP_036440.1
• Gene: KDM2A / 22992
• HGNCID: 13606
• Length: 1162
• Species: Homo sapiens
• Alignment Length: 271
• Identity: 61/271 - (22%)
• Similarity: 100/271 - (36%)
• Gaps: 82/271 - (30%)

  Fly   118 TQYKWFNAPETSFSNLTYVSLRRCQLNDENLVGWEFLTHLETLDLRYNDRLTGSCLMSLPTSLLS 182
            |.|||......    .|.:.|.||:......:.........:|||.:.
Human   919 TWYKWCCDKRL----WTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWT----------------- 962

  Fly   183 LYITGCRNLCPNQLIFL-NRIPRLRELRASDLMPGGHWHIYRDL-VLACPLLVMVEISICSLNRD 245
                   |:...||.:| ||:|.|::|    |:.|..|.....| ..:||||
Human   963 -------NISKKQLTWLVNRLPGLKDL----LLAGCSWSAVSALSTSSCPLL------------- 1003

  Fly   246 EYRLGELRYLQSLVIKAHSTDTIRCKVSDWMLISLLDVPFLRNLMFSDAPSGFVSANALSIISRF 310
              |..:||:...              :.|..:..||..|       :|.| |..:.:.|..::.|
Human  1004 --RTLDLRWAVG--------------IKDPQIRDLLTPP-------ADKP-GQDNRSKLRNMTDF 1044

  Fly   311 RQLRVLKMPNQPYRPNDLLRLRNLTFLETLDLSNSPYITNEVV-IELVIGIP---NLSVLIVQGC 371
            | |..|.:.:...|    |.:|::..|..||||:..::|::.. :...:|..   :|:.|.:.||
Human  1045 R-LAGLDITDATLR----LIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGC 1104

  Fly   372 PLLTNR--VYL 380
            ..||::  :||
Human  1105 NKLTDQTLIYL 1115

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15056	NP_573291.1	leucine-rich repeat	133..156	CDD:275381	4/22 (18%)
		leucine-rich repeat	157..179	CDD:275381	3/21 (14%)
		leucine-rich repeat	180..204	CDD:275381	6/24 (25%)
		leucine-rich repeat	205..231	CDD:275381	7/26 (27%)
		leucine-rich repeat	232..285	CDD:275381	7/52 (13%)
		leucine-rich repeat	286..326	CDD:275381	9/39 (23%)
		AMN1	306..>376	CDD:187754	19/73 (26%)
		leucine-rich repeat	337..362	CDD:275381	7/28 (25%)
KDM2A	NP_036440.1	cupin_like	199..299	CDD:328732
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	367..389
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	532..557
		zf-CXXC	<576..609	CDD:251032
		PHD_KDM2A	619..675	CDD:277113
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	704..789
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	839..887
		F-box-like	896..934	CDD:315592	5/18 (28%)
		leucine-rich repeat	930..954	CDD:275381	4/23 (17%)
		AMN1	932..1138	CDD:332986	56/254 (22%)
		leucine-rich repeat	955..978	CDD:275381	9/46 (20%)
		LRR 1	961..982		8/44 (18%)
		leucine-rich repeat	979..1002	CDD:275381	7/26 (27%)
		LRR 2	984..1010		9/40 (23%)
		leucine-rich repeat	1003..1040	CDD:275381	12/73 (16%)
		leucine-rich repeat	1041..1065	CDD:275381	7/28 (25%)
		LRR 3	1048..1073		8/28 (29%)
		leucine-rich repeat	1066..1095	CDD:275381	7/28 (25%)
		LRR 4	1074..1103		4/28 (14%)
		leucine-rich repeat	1096..1120	CDD:275381	8/20 (40%)
		LRR 5	1104..1128		5/12 (42%)
		leucine-rich repeat	1121..1140	CDD:275381
		LRR 6	1129..1156

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900