DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15056 and FBXL13

DIOPT Version :9

Sequence 1:	NP_573291.1	Gene:	CG15056 / 32824	FlyBaseID:	FBgn0030918	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001381423.1	Gene:	FBXL13 / 222235	HGNCID:	21658	Length:	825	Species:	Homo sapiens

Alignment Length:	375	Identity:	78/375 - (20%)
Similarity:	139/375 - (37%)	Gaps:	129/375 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 FAASCDMFENIYVRS-SPLRLSRVVNLEEMIEFSLLETKLFVELSGSDIEIIRGGPHTPMFS--H 92
            :.|.|....:..:|| |||:...|:||...:....:..|.|::           ||.:....  :
Human   522 YMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLD-----------GPASMRIRELN 575

  Fly    93 FEDFIRLMSIRLTKVNEIALEGFQLTQYKWFNAPETSFSNLTYVSLRRCQLNDENLVGWEFLTHL 157
            ..:.:||....:.|::|              ..|     ||.|:|||.|:             ||
Human   576 LSNCVRLSDASVMKLSE--------------RCP-----NLNYLSLRNCE-------------HL 608

  Fly   158 ETLDLRYNDRLTGSCLMSLPTSLLSLYITGCRNLCPNQLIFLNRIPRLRELRASDLMPGGHWHIY 222
            ....:.|        :::: .||:|:.::| .::....|..|:|..:|:||..|:.     :.|.
Human   609 TAQGIGY--------IVNI-FSLVSIDLSG-TDISNEGLNVLSRHKKLKELSVSEC-----YRIT 658

  Fly   223 RDLVLA-CP---LLVMVEISICSLNRDEYRLGELRYLQSLVIKAHSTDTIRCKVSDWMLISLLDV 283
            .|.:.| |.   :|..:::|.||            .|..::|||.:...|.
Human   659 DDGIQAFCKSSLILEHLDVSYCS------------QLSDMIIKALAIYCIN-------------- 697

  Fly   284 PFLRNLMFSDAPSGFVSANALSIISRFRQLRVLKMPNQPYRPNDLLRLRNLTFLETLDLSNSPYI 348
              |.:|..:..|.  ::.:|:.::|                       ....:|..||:|....:
Human   698 --LTSLSIAGCPK--ITDSAMEMLS-----------------------AKCHYLHILDISGCVLL 735

  Fly   349 TNEVVIELVIGIPNLSVLIVQGCPLLTNRVYLDAELASKKRSNGNMVKVQ 398
            |::::.:|.||...|.:|.:|.|   ||        .|||.:.....|||
Human   736 TDQILEDLQIGCKQLRILKMQYC---TN--------ISKKAAQRMSSKVQ 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15056	NP_573291.1	leucine-rich repeat	133..156	CDD:275381	6/22 (27%)
		leucine-rich repeat	157..179	CDD:275381	2/21 (10%)
		leucine-rich repeat	180..204	CDD:275381	6/23 (26%)
		leucine-rich repeat	205..231	CDD:275381	8/29 (28%)
		leucine-rich repeat	232..285	CDD:275381	9/52 (17%)
		leucine-rich repeat	286..326	CDD:275381	5/39 (13%)
		AMN1	306..>376	CDD:187754	13/69 (19%)
		leucine-rich repeat	337..362	CDD:275381	8/24 (33%)
FBXL13	NP_001381423.1	Sfi1	<112..>224	CDD:400658
		F-box-like	245..289	CDD:403981
		leucine-rich repeat	285..312	CDD:275381
		AMN1	312..497	CDD:187754
		leucine-rich repeat	313..336	CDD:275381
		leucine-rich repeat	337..362	CDD:275381
		leucine-rich repeat	363..387	CDD:275381
		leucine-rich repeat	388..406	CDD:275381
		leucine-rich repeat	416..441	CDD:275381
		leucine-rich repeat	442..491	CDD:275381
		leucine-rich repeat	468..490	CDD:275381
		leucine-rich repeat	492..515	CDD:275381
		leucine-rich repeat	518..542	CDD:275381	7/19 (37%)
		AMN1	529..737	CDD:187754	60/318 (19%)
		leucine-rich repeat	543..570	CDD:275381	7/37 (19%)
		leucine-rich repeat	571..596	CDD:275381	5/43 (12%)
		leucine-rich repeat	597..645	CDD:275381	16/70 (23%)
		leucine-rich repeat	646..671	CDD:275381	8/29 (28%)
		leucine-rich repeat	672..697	CDD:275381	8/36 (22%)
		leucine-rich repeat	698..723	CDD:275381	5/49 (10%)
		leucine-rich repeat	724..749	CDD:275381	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153064
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750