DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15056 and Fbxl16

DIOPT Version :9

Sequence 1:	NP_573291.1	Gene:	CG15056 / 32824	FlyBaseID:	FBgn0030918	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001366323.1	Gene:	Fbxl16 / 214931	MGIID:	2448488	Length:	575	Species:	Mus musculus

Alignment Length:	370	Identity:	86/370 - (23%)
Similarity:	147/370 - (39%)	Gaps:	102/370 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FDFFWLDVLKQLDLKSRISFAASCDMFENIY-----VRSSPLRLSRVVN--LEEMIEFSLLETKL 69
            |:.|.|..:..||:         |:..:|..     |::..|:.|.:.:  ||.|:|  .::..:
Mouse   264 FEGFCLVGVSDLDI---------CEFIDNYSLSKKGVKAMSLKRSTITDAGLEVMLE--QMQGVV 317

  Fly    70 FVELSGSDIEIIRGGPHTPMFSHF------------EDFIRLMSIRLTKVNEIALEGFQLTQ--Y 120
            .:||||.: :....|..:.:.:..            :|.|..:|..|..:.|::|:.:.:|.  .
Mouse   318 RLELSGCN-DFTEAGLWSSLSARITSLSVSDCINVADDAIAAISQLLPNLAELSLQAYHVTDTAL 381

  Fly   121 KWFNAPETSFSNLTYVSLRRCQLNDENLVGWEFLTHLETLDLRYNDRLTG--SCLMSLPTSLLSL 183
            .:|.|.:...::.  :.|..|         ||...|             |  :.:.||| :|.||
Mouse   382 AYFTARQGHSTHT--LRLLSC---------WEITNH-------------GVVNVVHSLP-NLTSL 421

  Fly   184 YITGCRNLCPN--QLIFLNRIPRLRELRASDLMPGGHWHIYRDLVLACPLL--VMVEISICSLNR 244
            .::||..:..:  :|:..|    ||:||:.||    .|         ||.:  :.:|...|.|:|
Mouse   422 SLSGCSKVTDDGVELVAEN----LRKLRSLDL----SW---------CPRITDMALEYVACDLHR 469

  Fly   245 DEYRLGELRYLQSLVIKAHSTDTIRC-KVSDWMLISLLDVPFLRNLMFSDAPSGFVSANALSIIS 308
                      |:.||:.       || :::|..|..|..:..||:|.......  |....|..:.
Mouse   470 ----------LEELVLD-------RCVRITDTGLSYLSTMSSLRSLYLRWCCQ--VQDFGLKHLL 515

  Fly   309 RFRQLRVLKMPNQP-YRPNDLLRLRNLTFLETLDLSNSPYITNEV 352
            ..|.||:|.:...| .....|..|..|..||.|:|:|.|..|.|:
Mouse   516 AMRNLRLLSLAGCPLLTTTGLSGLVQLQELEELELTNCPGATPEL 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15056	NP_573291.1	leucine-rich repeat	133..156	CDD:275381	4/22 (18%)
		leucine-rich repeat	157..179	CDD:275381	4/23 (17%)
		leucine-rich repeat	180..204	CDD:275381	7/25 (28%)
		leucine-rich repeat	205..231	CDD:275381	8/25 (32%)
		leucine-rich repeat	232..285	CDD:275381	12/55 (22%)
		leucine-rich repeat	286..326	CDD:275381	10/40 (25%)
		AMN1	306..>376	CDD:187754	16/48 (33%)
		leucine-rich repeat	337..362	CDD:275381	8/16 (50%)
Fbxl16	NP_001366323.1	PHA03247	<31..193	CDD:223021
		AMN1	297..509	CDD:187754	60/275 (22%)
		leucine-rich repeat	316..339	CDD:275381	5/23 (22%)
		leucine-rich repeat	340..365	CDD:275381	4/24 (17%)
		leucine-rich repeat	366..391	CDD:275381	5/24 (21%)
		leucine-rich repeat	392..417	CDD:275381	9/49 (18%)
		leucine-rich repeat	418..443	CDD:275381	8/28 (29%)
		leucine-rich repeat	444..469	CDD:275381	10/37 (27%)
		leucine-rich repeat	470..494	CDD:275381	8/30 (27%)
		leucine-rich repeat	495..514	CDD:275381	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1282076at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910