DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32549 and Nt5c2

DIOPT Version :9

Sequence 1:	NP_728163.2	Gene:	CG32549 / 32822	FlyBaseID:	FBgn0052549	Length:	709	Species:	Drosophila melanogaster
Sequence 2:	NP_001157835.1	Gene:	Nt5c2 / 76952	MGIID:	2178563	Length:	586	Species:	Mus musculus

Alignment Length:	564	Identity:	339/564 - (60%)
Similarity:	408/564 - (72%)	Gaps:	21/564 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 SAPNTPGPCSTSALPKKYYRYAAHRVFVNRSLHLENIKYYGFDMDYTLAEYKSPQYEQLGFNLVK 196
            :|.:.|......|| |||.|.|.|||||||||.:|.||.:|||||||||.||||:||.|||.|..
Mouse    37 NAADVPANMDKHAL-KKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVYKSPEYESLGFELTV 100

  Fly   197 ERLVFMGYPKEILQFEYDPTFPVRGLWFDTLYGNLLKVDAYGNILVCVHGFEFIKHHQVYELYPN 261
            ||||.:|||:|:|.|.||.|||.|||.||||||||||||||||:|||.|||.||:..:..|.|||
Mouse   101 ERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLVCAHGFNFIRGPETREQYPN 165

  Fly   262 KFLKLDES-RVYVLNTLFNLPETYLLACLVDFLTNSSDFVRVERGIKAGDLLFTYKSIFQDVRRA 325
            ||::.|:: |.|:|||||||||||||||||||.||...:...:.|.|.|||..:|:|:|||||.|
Mouse   166 KFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTSCDTGFKDGDLFMSYRSMFQDVRDA 230

  Fly   326 VDWVHSDGDLKRRTTQNMAHYVKKDERLPTVLSRIRESGAKLFMLTNSDYTYTNEIMTYLFDFPH 390
            |||||..|.||.:|.:|:..||.||.:||.:|||::|.| |:|:.|||||.||::||||||||||
Mouse   231 VDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMKEVG-KVFLATNSDYKYTDKIMTYLFDFPH 294

  Fly   391 GATPDEPHRDWKTYFDVIVVDARKPLFFDEGTVLRQVDTKTGSLKIGTHVGPLQPGQVYSGGSCE 455
            |..|...||.|::|||:|:|||||||||.|||||||||||||.|||||:.||||.|.||||||.:
Mouse   295 GPKPGSSHRPWQSYFDLILVDARKPLFFGEGTVLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSD 359

  Fly   456 LFTKFINAKGKDVLYVGDHIFGDILKSKKIRGWRTFLIVPELVRELHVWTDECQLFAELQNLDIK 520
            .....:.|||||:||:|||||||||||||.:||||||::|||.:|||||||:..||.|||:|||.
Mouse   360 TICDLLGAKGKDILYIGDHIFGDILKSKKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIF 424

  Fly   521 LGDLYRDLDSSAKVKPDISQLRTCIRDVTHKMDMSYGMMGSLFRSGSRQTFFSSQVVRYADVYAA 585
            |.:||:.||||:..:||||.::..|:.|||.|||.|||||||||||||||.|:|||:||||:|||
Mouse   425 LAELYKHLDSSSNERPDISSIQRRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAA 489

  Fly   586 TLLNLIYYPFSYMFRAPAMLLPHESTVAHDQA--HQPPPPLGPVPVPATGAASV-AASPDEPARI 647
            :.:||:||||||:|||..:|:||||||.|...  ::...||.     .....|| ....|.....
Mouse   490 SFINLLYYPFSYLFRAAHVLMPHESTVEHTHVDINEMESPLA-----TRNRTSVDFKDTDYKRHQ 549

  Fly   648 LAGTAEHVKDPKDLHRASSIVHTRPSTPTVVTHTHDEDYSEEEE 691
            |..:...:|.|          :..|..|..:||.||||..||||
Mouse   550 LTRSISEIKPP----------NLFPLAPQEITHCHDEDDDEEEE 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32549	NP_728163.2	5_nucleotid	165..610	CDD:283430	296/445 (67%)
Nt5c2	NP_001157835.1	5_nucleotid	69..514	CDD:283430	296/445 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843195
Domainoid	1	1.000	637	1.000	Domainoid score	I169
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8158
Inparanoid	1	1.050	667	1.000	Inparanoid score	I745
Isobase	1	0.950	-	0	Normalized mean entropy	S2957
OMA	1	1.010	-	-		QHG55235
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002997
OrthoInspector	1	1.000	-	-		oto92645
orthoMCL	1	0.900	-	-		OOG6_103812
Panther	1	1.100	-	-	O	PTHR12103
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4353
SonicParanoid	1	1.000	-	-		X1990
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.880