Protein Alignment Nt5b and NT5C2

DIOPT Version :10

• Sequence 1: NP_728163.2
• Gene: Nt5b / 32822
• FlyBaseID: FBgn0052549
• Length: 709
• Species: Drosophila melanogaster
• Sequence 2: NP_001338099.1
• Gene: NT5C2 / 22978
• HGNCID: 8022
• Length: 569
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 342/572 - (59%)
• Similarity: 409/572 - (71%)
• Gaps: 29/572 - (5%)

  Fly   132 SAPNTPGPCSTSALPKKYYRYAAHRVFVNRSLHLENIKYYGFDMDYTLAEYKSPQYEQLGFNLVK 196
            :|.:.|......|| |||.|.|.|||||||||.:|.||.:|||||||||.||||:||.|||.|..
Human    11 NAADMPANMDKHAL-KKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVYKSPEYESLGFELTV 74

  Fly   197 ERLVFMGYPKEILQFEYDPTFPVRGLWFDTLYGNLLKVDAYGNILVCVHGFEFIKHHQV------ 255
            ||||.:|||:|:|.|.||.|||.|||.||||||||||||||||:|||.|||.||:..||
Human    75 ERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLVCAHGFNFIRGSQVAVQKRP 139

  Fly   256 --YELYPNKFLKLDES-RVYVLNTLFNLPETYLLACLVDFLTNSSDFVRVERGIKAGDLLFTYKS 317
              .|.|||||::.|:: |.|:|||||||||||||||||||.||...:...|.|.|.|||..:|:|
Human   140 ETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTSCETGFKDGDLFMSYRS 204

  Fly   318 IFQDVRRAVDWVHSDGDLKRRTTQNMAHYVKKDERLPTVLSRIRESGAKLFMLTNSDYTYTNEIM 382
            :|||||.||||||..|.||.:|.:|:..||.||.:||.:|||::|.| |:|:.|||||.||::||
Human   205 MFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMKEVG-KVFLATNSDYKYTDKIM 268

  Fly   383 TYLFDFPHGATPDEPHRDWKTYFDVIVVDARKPLFFDEGTVLRQVDTKTGSLKIGTHVGPLQPGQ 447
            |||||||||..|...||.|::|||:|:|||||||||.|||||||||||||.|||||:.||||.|.
Human   269 TYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGTVLRQVDTKTGKLKIGTYTGPLQHGI 333

  Fly   448 VYSGGSCELFTKFINAKGKDVLYVGDHIFGDILKSKKIRGWRTFLIVPELVRELHVWTDECQLFA 512
            ||||||.:.....:.|||||:||:|||||||||||||.:||||||::|||.:|||||||:..||.
Human   334 VYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKSKKRQGWRTFLVIPELAQELHVWTDKSSLFE 398

  Fly   513 ELQNLDIKLGDLYRDLDSSAKVKPDISQLRTCIRDVTHKMDMSYGMMGSLFRSGSRQTFFSSQVV 577
            |||:|||.|.:||:.||||:..:||||.::..|:.|||.|||.|||||||||||||||.|:|||:
Human   399 ELQSLDIFLAELYKHLDSSSNERPDISSIQRRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVM 463

  Fly   578 RYADVYAATLLNLIYYPFSYMFRAPAMLLPHESTVAHDQA--HQPPPPLGPVPVPATGAASV-AA 639
            ||||:|||:.:||:||||||:|||..:|:||||||.|...  ::...||.     .....|| ..
Human   464 RYADLYAASFINLLYYPFSYLFRAAHVLMPHESTVEHTHVDINEMESPLA-----TRNRTSVDFK 523

  Fly   640 SPDEPARILAGTAEHVKDPKDLHRASSIVHTRPSTPTVVTHTHDEDYSEEEE 691
            ..|.....|..:...:|.|          :..|..|..:||.||||..||||
Human   524 DTDYKRHQLTRSISEIKPP----------NLFPLAPQEITHCHDEDDDEEEE 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nt5b	NP_728163.2	5_nucleotid	165..611	CDD:461733	300/454 (66%)
NT5C2	NP_001338099.1	5_nucleotid	43..497	CDD:461733	300/454 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	546..569		12/20 (60%)
		Required for tetramer assembly. /evidence=ECO:0000269|PubMed:10092873	556..569		8/10 (80%)