DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsf1 and 1300017J02Rik

DIOPT Version :9

Sequence 1:	NP_001285404.1	Gene:	Tsf1 / 32821	FlyBaseID:	FBgn0022355	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_082194.1	Gene:	1300017J02Rik / 71775	MGIID:	1919025	Length:	700	Species:	Mus musculus

Alignment Length:	745	Identity:	175/745 - (23%)
Similarity:	286/745 - (38%)	Gaps:	208/745 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LAVAALLLI--LGPQSSLAEEPIYRLCVPQIYLA-ECQQLLADPSE----AGIRMECVAGRDRVD 70
            |.:.|||.:  ||...:|.|:.| |.||...:.| :|.....:..:    .|..:.||......:
Mouse     3 LLICALLCLGTLGLCLALPEKTI-RWCVVSDHEATKCSSFRDNMKKVLPAGGPAVTCVRKMSHPE 66

  Fly    71 CLELIEQRKADVLATE---PEDMYIAYHRKNEDYRVISEIRTQQDKDAAFRYEGIILVKKDSPIR 132
            |:..|...|.|.:..:   ..:..:.:|....   :::|....:| |....|..:.:.||.:..:
Mouse    67 CIRDISANKVDAVTVDGALVAEADLPHHSLKP---IMAEYYGSKD-DPKTHYYVVAMAKKGTGFQ 127

  Fly   133 TLQQLRGAKSCHTGFGRNVGYKIPITKLKNTHVLKVSADPQISATERELKSLSEFFTQSCLVGTY 197
             |.||||.||||||.|.:.|:.:|::.|             :.:..|| .:.:.||:.||:
Mouse   128 -LNQLRGKKSCHTGLGWSAGWYVPLSTL-------------LPSGSRE-TAAATFFSSSCV---- 173

  Fly   198 STHPETDRLLKKKYANLCALCEKPE----QCNYPDKFSGYDGAIRCLDKGQGEVAFSKVQYIKKY 258
               |..|   .|.:.:||.||....    .|:..:.:.|..||::||..|..:|:|  |:::..:
Mouse   174 ---PCAD---GKMFPSLCQLCAGKGTDKCACSSREPYFGSWGALKCLQDGTADVSF--VKHLTVF 230

  Fly   259 FGLPGAGPDAPPAEGNPENFEYLCEDGTRRPVTG-PACSWAQRPWSGYISNEQAVHNSEQLHQ-- 320
                    :|.|.:.:.:.:|.||.|.|||||.. ..|..|:.|  .::...::|...|...|
Mouse   231 --------EAMPTKADRDQYELLCMDNTRRPVEEYEQCYLARVP--SHVVVARSVDGKEDSIQEL 285

  Fly   321 LQSRLERFFANGLQAQNKDAAAHLLIQPNAVYHSK-----DAA---------IDPKVYLERAGYK 371
            |:...|.|      .::|.:...|...|    |.:     |||         ||..:||   ||:
Mouse   286 LRVAQEHF------GKDKSSPFQLFGSP----HGEDLLFTDAAHGLLRVPRKIDISLYL---GYE 337

  Fly   372 DV-----IERDGSAIRKIRLCAQNDDEFAKCQ--------ALHQAAYARDARPELECVQSTDCVV 423
            .:     ::|.....::::.||....|..||.        ||   |.|.:..||       ||:.
Mouse   338 FLSAFRNLKRGLEDSQRVKWCAVGQQERTKCDQWSAVSGGAL---ACATEETPE-------DCIA 392

  Fly   424 ALTKKEAD----------------LTIVRATGYADARSN-QLQPIVYEQRAQDDVLVAVAAP--- 468
            |..|.|||                |..|.|..|....|: :|.........:...:|||...
Mouse   393 ATMKGEADAMSLDGGFAYVAGHCGLVPVLAENYLSTHSSGRLGSKCVNAPLEGYYVVAVVKKSDV 457

  Fly   469 GVTREAL-------------------------QKASIKFNENCERSRAAAA-------------- 494
            |:|.::|                         |..|.||:....||.|..:
Mouse   458 GITWKSLQGKKSCHTAVGTSEGWNVPMGLIYNQTGSCKFDAFFSRSCAPGSDPDSPLCALCVGGN 522

  Fly   495 ------LLNKRRGLDA------CRVSSSD-------------DGEVQIVPASELEKHKDAQLVCP 534
                  ..|...|...      |.|...|             ||: ...|.::..||:|.:|:|.
Mouse   523 NPAHMCAANNAEGYHGSSGALRCLVEKGDVAFMKHPTVLQNTDGK-NPEPWAKGLKHEDFELLCL 586

  Fly   535 SLERRPVTDFRDCNVDVQLP-RAIFIRSDTTSVEQETVKHLFSLISDKFGARGKLVDVFALFGEF 598
            ...|:|||:.:.|:: .::| ||:|.|.|    :.:.|:.:.....:.||..|   ..:.:|..|
Mouse   587 DGTRKPVTEAQSCHL-ARVPNRAVFSRKD----KADFVRRILFNQQELFGRNG---FEYMMFQMF 643

  Fly   599 QKGKKNVYFNDKAVQLTTELKNEIQNEQIY 628
            :...|::.|:|     .||..:.:||:..|
Mouse   644 ESSAKDLLFSD-----DTECLSNLQNKTTY 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf1	NP_001285404.1	PBP2_transferrin	34..>302	CDD:270247	70/280 (25%)
		Periplasmic_Binding_Protein_Type_2	384..615	CDD:304360	70/323 (22%)
		TR_FER	384..614	CDD:214514	70/322 (22%)
1300017J02Rik	NP_082194.1	PBP2_transferrin_N	24..346	CDD:270336	91/376 (24%)
		Transferrin	25..346	CDD:278817	91/375 (24%)
		PBP2_transferrin_C	352..684	CDD:270335	75/341 (22%)
		TR_FER	355..685	CDD:214514	75/338 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KI0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	140	1.000	Inparanoid score	I4482
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11485
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.920