Protein Alignment Tsf1 and TF

DIOPT Version :10

• Sequence 1: NP_523401.2
• Gene: Tsf1 / 32821
• FlyBaseID: FBgn0022355
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_001054.2
• Gene: TF / 7018
• HGNCID: 11740
• Length: 698
• Species: Homo sapiens
• Alignment Length: 720
• Identity: 169/720 - (23%)
• Similarity: 275/720 - (38%)
• Gaps: 183/720 - (25%)

  Fly    13 LAVAALLL--ILGPQSSLAEEPIYRLCVPQIYLAECQQL-----LADPSEAGIRMECVAGRDRVD 70
            |||.|||:  :||...::.::.:....|.:....:||..     ...||: |..:.||.....:|
Human     3 LAVGALLVCAVLGLCLAVPDKTVRWCAVSEHEATKCQSFRDHMKSVIPSD-GPSVACVKKASYLD 66

  Fly    71 CLELIEQRKADVLATEPEDMYIAYHRKNEDYRVISEIRTQQDKDAAFRYEGIILVKKDSPIRTLQ 135
            |:..|...:||.:..:...:|.||...|....|::|....::....| |..:.:|||||..: :.
Human    67 CIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTF-YYAVAVVKKDSGFQ-MN 129

  Fly   136 QLRGAKSCHTGFGRNVGYKIPITKLKNTHVLKVSADPQISATEREL-KSLSEFFTQSCLVGTYST 199
            ||||.||||||.||:.|:.|||..|.          ..:....:.| |:::.||:.||......|
Human   130 QLRGKKSCHTGLGRSAGWNIPIGLLY----------CDLPEPRKPLEKAVANFFSGSCAPCADGT 184

  Fly   200 HPETDRLLKKKYANLCALCEKPE-QCNYPDKFSGYDGAIRCLDKGQGEVAFSKVQYIKKYFGLPG 263
                      .:..||.||  |. .|:..:::.||.||.:||..|.|:|||.|...|.:...
Human   185 ----------DFPQLCQLC--PGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLA--- 234

  Fly   264 AGPDAPPAEGNPENFEYLCEDGTRRPVTG-PACSWAQRPWSGYISNEQAVHNS---EQLHQLQSR 324
                   .:.:.:.:|.||.|.||:||.. ..|..||.|....::........   |.|:|.|
Human   235 -------NKADRDQYELLCLDNTRKPVDEYKDCHLAQVPSHTVVARSMGGKEDLIWELLNQAQ-- 290

  Fly   325 LERFFANGLQAQNKDAAAHLLIQPNAVYHSKD--------------AAIDPKVYLERAGYKDVIE 375
             |.|      .::|.....|...|    |.||              ..:|.|:||   ||:.|..
Human   291 -EHF------GKDKSKEFQLFSSP----HGKDLLFKDSAHGFLKVPPRMDAKMYL---GYEYVTA 341

  Fly   376 ----RDGSA-------IRKIRLCAQNDDEFAKCQALHQAAYARDARPELECVQ---STDCVVALT 426
                |:|:.       .:.::.||.:..|..||.     .::.::..::|||.   :.||:..:.
Human   342 IRNLREGTCPEAPTDECKPVKWCALSHHERLKCD-----EWSVNSVGKIECVSAETTEDCIAKIM 401

  Fly   427 KKEADLTIVRATGYADARSNQLQPIVYEQRAQDD-------------VLVAVAAPGVTREALQ-K 477
            ..|||...:.......|....|.|::.|...:.|             .:|..:|..:|.:.|: |
Human   402 NGEADAMSLDGGFVYIAGKCGLVPVLAENYNKSDNCEDTPEAGYFAIAVVKKSASDLTWDNLKGK 466

  Fly   478 ASIK----------------------------FNENC---ERSRAAAALLNKRRGLDACRVSSS- 510
            .|..                            |:|.|   .:..::...|....||:.|..::.
Human   467 KSCHTAVGRTAGWNIPMGLLYNKINHCRFDEFFSEGCAPGSKKDSSLCKLCMGSGLNLCEPNNKE 531

  Fly   511 -------------DDGEV-----QIVPASELEKH----------KDAQLVCPSLERRPVTDFRDC 547
                         :.|:|     |.||.:...|:          ||.:|:|....|:||.::.:|
Human   532 GYYGYTGAFRCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANC 596

  Fly   548 NVDVQLPRAIFIRSDTTSVEQETVK---HLFSLISDKFGARGKLVDVFALFGEFQKGKKNVYFND 609
            ::......|:..|.|..:...:.::   |||.         ..:.|....|..|:...|::.|.|
Human   597 HLARAPNHAVVTRKDKEACVHKILRQQQHLFG---------SNVTDCSGNFCLFRSETKDLLFRD 652

  Fly   610 KAVQL 614
            ..|.|
Human   653 DTVCL 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsf1	NP_523401.2	TR_FER	34..323	CDD:214514	84/299 (28%)
		Periplasmic_Binding_Protein_Type_2	384..615	CDD:473866	59/311 (19%)
TF	NP_001054.2	PBP2_transferrin_N	24..346	CDD:270336	100/372 (27%)
		PBP2_transferrin_C	358..682	CDD:270335	59/314 (19%)