DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsf1 and TF

DIOPT Version :9

Sequence 1:	NP_001285404.1	Gene:	Tsf1 / 32821	FlyBaseID:	FBgn0022355	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001054.2	Gene:	TF / 7018	HGNCID:	11740	Length:	698	Species:	Homo sapiens

Alignment Length:	720	Identity:	169/720 - (23%)
Similarity:	275/720 - (38%)	Gaps:	183/720 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LAVAALLL--ILGPQSSLAEEPIYRLCVPQIYLAECQQL-----LADPSEAGIRMECVAGRDRVD 70
            |||.|||:  :||...::.::.:....|.:....:||..     ...||: |..:.||.....:|
Human     3 LAVGALLVCAVLGLCLAVPDKTVRWCAVSEHEATKCQSFRDHMKSVIPSD-GPSVACVKKASYLD 66

  Fly    71 CLELIEQRKADVLATEPEDMYIAYHRKNEDYRVISEIRTQQDKDAAFRYEGIILVKKDSPIRTLQ 135
            |:..|...:||.:..:...:|.||...|....|::|....::....| |..:.:|||||..: :.
Human    67 CIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTF-YYAVAVVKKDSGFQ-MN 129

  Fly   136 QLRGAKSCHTGFGRNVGYKIPITKLKNTHVLKVSADPQISATEREL-KSLSEFFTQSCLVGTYST 199
            ||||.||||||.||:.|:.|||..|.          ..:....:.| |:::.||:.||......|
Human   130 QLRGKKSCHTGLGRSAGWNIPIGLLY----------CDLPEPRKPLEKAVANFFSGSCAPCADGT 184

  Fly   200 HPETDRLLKKKYANLCALCEKPE-QCNYPDKFSGYDGAIRCLDKGQGEVAFSKVQYIKKYFGLPG 263
                      .:..||.||  |. .|:..:::.||.||.:||..|.|:|||.|...|.:...
Human   185 ----------DFPQLCQLC--PGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLA--- 234

  Fly   264 AGPDAPPAEGNPENFEYLCEDGTRRPVTG-PACSWAQRPWSGYISNEQAVHNS---EQLHQLQSR 324
                   .:.:.:.:|.||.|.||:||.. ..|..||.|....::........   |.|:|.|
Human   235 -------NKADRDQYELLCLDNTRKPVDEYKDCHLAQVPSHTVVARSMGGKEDLIWELLNQAQ-- 290

  Fly   325 LERFFANGLQAQNKDAAAHLLIQPNAVYHSKD--------------AAIDPKVYLERAGYKDVIE 375
             |.|      .::|.....|...|    |.||              ..:|.|:||   ||:.|..
Human   291 -EHF------GKDKSKEFQLFSSP----HGKDLLFKDSAHGFLKVPPRMDAKMYL---GYEYVTA 341

  Fly   376 ----RDGSA-------IRKIRLCAQNDDEFAKCQALHQAAYARDARPELECVQ---STDCVVALT 426
                |:|:.       .:.::.||.:..|..||.     .::.::..::|||.   :.||:..:.
Human   342 IRNLREGTCPEAPTDECKPVKWCALSHHERLKCD-----EWSVNSVGKIECVSAETTEDCIAKIM 401

  Fly   427 KKEADLTIVRATGYADARSNQLQPIVYEQRAQDD-------------VLVAVAAPGVTREALQ-K 477
            ..|||...:.......|....|.|::.|...:.|             .:|..:|..:|.:.|: |
Human   402 NGEADAMSLDGGFVYIAGKCGLVPVLAENYNKSDNCEDTPEAGYFAIAVVKKSASDLTWDNLKGK 466

  Fly   478 ASIK----------------------------FNENC---ERSRAAAALLNKRRGLDACRVSSS- 510
            .|..                            |:|.|   .:..::...|....||:.|..::.
Human   467 KSCHTAVGRTAGWNIPMGLLYNKINHCRFDEFFSEGCAPGSKKDSSLCKLCMGSGLNLCEPNNKE 531

  Fly   511 -------------DDGEV-----QIVPASELEKH----------KDAQLVCPSLERRPVTDFRDC 547
                         :.|:|     |.||.:...|:          ||.:|:|....|:||.::.:|
Human   532 GYYGYTGAFRCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANC 596

  Fly   548 NVDVQLPRAIFIRSDTTSVEQETVK---HLFSLISDKFGARGKLVDVFALFGEFQKGKKNVYFND 609
            ::......|:..|.|..:...:.::   |||.         ..:.|....|..|:...|::.|.|
Human   597 HLARAPNHAVVTRKDKEACVHKILRQQQHLFG---------SNVTDCSGNFCLFRSETKDLLFRD 652

  Fly   610 KAVQL 614
            ..|.|
Human   653 DTVCL 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf1	NP_001285404.1	PBP2_transferrin	34..>302	CDD:270247	80/275 (29%)
		Periplasmic_Binding_Protein_Type_2	384..615	CDD:304360	59/311 (19%)
		TR_FER	384..614	CDD:214514	58/309 (19%)
TF	NP_001054.2	PBP2_transferrin_N	24..346	CDD:270336	100/372 (27%)
TF	NP_001054.2	PBP2_transferrin_C	358..682	CDD:270335	59/314 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KI0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11485
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.880