DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsf1 and meltf

DIOPT Version :9

Sequence 1:	NP_001285404.1	Gene:	Tsf1 / 32821	FlyBaseID:	FBgn0022355	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	XP_009300716.1	Gene:	meltf / 565942	ZFINID:	ZDB-GENE-050309-40	Length:	724	Species:	Danio rerio

Alignment Length:	768	Identity:	177/768 - (23%)
Similarity:	284/768 - (36%)	Gaps:	210/768 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TWLPLAV-AALLLILGPQSSLAEEPIYRLCVPQIYLAE---CQQLLADPSEAGIR--MECVAGRD 67
            ||..|:| .||...:..||::      |.||  |.:||   |:.:....|.|.:|  ::||....
Zfish     3 TWTFLSVLLALTHYVSGQSTI------RWCV--ISVAEESKCKAMAQAFSSASVRPALKCVLAAS 59

  Fly    68 RVDCLELIEQRK-ADVLATEPEDMY---------IAYHRKNEDYRVISEIRTQQDKDAAFRYEGI 122
            :.:|.:.:.|:| .|..:...:|:|         ||......|.:.|:             |.|:
Zfish    60 KAECAQKLTQKKEVDAFSASAKDIYDIGKLASFKIAAGESGSDGKGIT-------------YYGV 111

  Fly   123 ILVKKDSPIRTLQQLRGAKSCHTGFGRNVGYKIPITKLKNTHVLKVSA--DPQISATERELKSLS 185
            .:|||.:....:..|:|.||||||..|..|:.:|:..|.::.::.|..  .||         .::
Zfish   112 AVVKKTNAAININNLKGKKSCHTGKNRTAGWNVPLGYLIDSGMMSVMGCNIPQ---------GVA 167

  Fly   186 EFFTQSCLVGTYSTHPETDRLLKKKYANLCALC--EKPEQ--CNYPDK--FSGYDGAIRCLDKGQ 244
            :||..||:.|.           |...|:||..|  ::..|  |:..:|  :..||||.|||.:..
Zfish   168 DFFNASCIPGA-----------KDDPASLCQQCVGDRTGQFKCDPSNKELYYAYDGAFRCLVEDA 221

  Fly   245 GEVAFSKVQYIKKYFGLPGAGPDAPPAEGNPENFEYLCEDGTRRPVTG-PACSWAQRPWSGYISN 308
            |:|||.|...:.:.....||   :...|...::::.||.||||.|||. ..|..|:.|..|.:.:
Zfish   222 GDVAFVKHTTVSENTDGKGA---SWAQELQSKDYQLLCRDGTRSPVTDYEKCHLARVPSRGIVIH 283

  Fly   309 ----EQAVHN--SEQLHQLQSRLERFFANGLQAQN---KDAAAHLLIQPNAVYHSKDAAIDPKVY 364
                ...|:|  :|.|.  :|....|.:.....:|   .|.:...:...|..|         |.:
Zfish   284 PDITTSVVYNMLTEGLQ--KSGFSMFSSADFGGENLLFSDTSTKFIQAGNENY---------KEW 337

  Fly   365 LERAGYKDVIE----RDGSAIRKIRLCAQNDDEFAKCQALHQAAYARDARPELECVQST---DCV 422
            :.|  |..:::    .......:::.|..:..|..||..:..|...::..|.::||...   ||:
Zfish   338 MGR--YYHILKAMDCSQSDIPSQLQWCVLSHGEQQKCADMAVAFKNKNLIPNIQCVYGASVEDCM 400

  Fly   423 VALTKKEAD-LTIVRATGYADARSNQLQPIVYEQRAQD---DVLVAVAAPGVTREALQKAS-IKF 482
            ..:..|||| :|:.....|...:|..|.|.|.|....|   .:..|||....:...:|:.| :|.
Zfish   401 KKIQNKEADAITLDGGYIYTAGKSYGLIPAVGESYTGDSDGSIYYAVAVLRKSNRDIQRFSDLKG 465

  Fly   483 NENCERSRAAAALLNKRRGL---------DACRVSSS---------------------------- 510
            ..:|.......|..|...||         ..|:|:.:
Zfish   466 KRSCHTGYGRTAGWNIPMGLLIEKGIIRPQTCQVAQAAGEFFESACVPGADQKDFPENLCKQCIG 530

  Fly   511 -DDGEVQIVPASEL------------EKHKDA-----------------------------QLVC 533
             ..|:.:.|...:|            |.|.|.                             ||:|
Zfish   531 DSSGQFKCVKGKDLYDGYDGAFRCLVENHGDVAFVKHSTVFQNTDGNNTDPWAVNLDSREFQLLC 595

  Fly   534 PSLERRPVTDFRDCNVDVQLPRAIFIRSDTTSVEQETVKHLFSLISDK----FGARG----KLVD 590
            ....|..||.|..||:......|:.||.||.       .|:...:.||    ||...    |:.|
Zfish   596 SQESRAEVTQFTKCNLARVPSHAVMIRPDTN-------HHIIFGLLDKAQRFFGVNSASDFKMFD 653

  Fly   591 VFALFGEFQKGKKNVYFNDKAVQLTTELKNEIQNE---QIYTD----LQCNAN 636
            ..|..|      .::.|.|..:.|....:.:...|   |.|.|    ::|:|:
Zfish   654 SKAYEG------SDLIFKDSTITLIGVGERKTYEEWLGQSYLDSLIAMECSAS 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf1	NP_001285404.1	PBP2_transferrin	34..>302	CDD:270247	81/291 (28%)
		Periplasmic_Binding_Protein_Type_2	384..615	CDD:304360	66/325 (20%)
		TR_FER	384..614	CDD:214514	66/324 (20%)
meltf	XP_009300716.1	PBP2_transferrin	22..343	CDD:270247	96/377 (25%)
		TR_FER	23..349	CDD:214514	96/382 (25%)
		Periplasmic_Binding_Protein_Type_2	358..689	CDD:304360	69/343 (20%)
		TR_FER	360..689	CDD:214514	69/341 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KI0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.780