Protein Alignment Tsf1 and MELTF

DIOPT Version :10

• Sequence 1: NP_523401.2
• Gene: Tsf1 / 32821
• FlyBaseID: FBgn0022355
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: XP_011511152.1
• Gene: MELTF / 4241
• HGNCID: 7037
• Length: 765
• Species: Homo sapiens
• Alignment Length: 759
• Identity: 164/759 - (21%)
• Similarity: 277/759 - (36%)
• Gaps: 229/759 - (30%)

  Fly    10 WLPLAVAALLLILGPQSSLAEEPIYRLCV---PQIYLAECQQLLADPSEAGIR--MECVAGRDRV 69
            ||.|   ||..:||...       .|.|.   |:.:  :|..:.....||||:  :.||.|....
Human     9 WLLL---ALRTVLGGME-------VRWCATSDPEQH--KCGNMSEAFREAGIQPSLLCVRGTSAD 61

  Fly    70 DCLELIEQRKADVLATEPEDMYIAYHRKNEDYR-VISEIRTQQDKDAAFRYEGIILVKKDSPIRT 133
            .|::||..::||.:..:...:|.|  .|....: |:.|:   .|::....|..:.:|::.|.: |
Human    62 HCVQLIAAQEADAITLDGGAIYEA--GKEHGLKPVVGEV---YDQEVGTSYYAVAVVRRSSHV-T 120

  Fly   134 LQQLRGAKSCHTGFGRNVGYKIPITKLKNTHVLKV-SADPQISATERELKSLSEFFTQSCLVGTY 197
            :..|:|.||||||..|.||:.:|:..|..:..|.| ..|        .||::|::|..||:.|..
Human   121 IDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCD--------VLKAVSDYFGGSCVPGAG 177

  Fly   198 STHPETDRLLKKKYA-NLCALCEKPEQ----CNYP--DKFSGYDGAIRCLDKGQGEVAFSKVQYI 255
            .|          .|: :||.||.....    |:..  :::..|.||.|||.:|.|:|||.|...:
Human   178 ET----------SYSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTV 232

  Fly   256 KKYFGLPGAGPDAPPAEGN---PENFEYLCEDGTRRPVT-GPACSWAQRPWSGYISNE------- 309
                 |........|:.|.   .::||.||.||:|..|| ...|..|:.|....:...
Human   233 -----LENTDGKTLPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGGLI 292

  Fly   310 -QAVHNSEQLHQLQSRLERFFANGLQAQN----KDAAAHLLIQPNAVYHS----------KDAAI 359
             :.::..::|...:....:.|::....|.    ||:.:.|:......|.:          |....
Human   293 FRLLNEGQRLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVPIATQTYEAWLGHEYLHAMKGLLC 357

  Fly   360 DPK---VYLERAGYKDVIERDGSAIRKIRLCAQNDDEFAKCQALHQAAYARDARPELECVQSTD- 420
            ||.   .||                   |.|..:..|..||..:..|...:..:||::||.:..
Human   358 DPNRLPPYL-------------------RWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSP 403

  Fly   421 --CVVALTKKEAD-LTIVRATGYADARSNQLQPIVYEQRAQDD-----VLVAVAAPGVTREA--- 474
              |:..:..::.| :|:.....|...::..|.|...|..|.:|     .:|||    |.|::
Human   404 QHCMERIQAEQVDAVTLSGEDIYTAGKTYGLVPAAGEHYAPEDSSNSYYVVAV----VRRDSSHA 464

  Fly   475 -----------------------------LQKASIK-------------FNENC--------ERS 489
                                         :|:..|:             ||.:|        ..|
Human   465 FTLDELRGKRSCHAGFGSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPS 529

  Fly   490 RAAAALLNKRRGLDACRVSSSDD----------------GEVQIVP----------------ASE 522
            ...|..:...:|.:.| |.:|.:                |:|..|.                |:|
Human   530 SLCALCVGDEQGRNKC-VGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAE 593

  Fly   523 LEKHKDAQLVCPSLERRPVTDFRDCNVDVQLPRAIFIRSDTTSVEQETVKHLFSLISDKFGARGK 587
            | :.:|.:|:||:..|..|:.|..||:....|.|:.:|.||
Human   594 L-RSEDYELLCPNGARAEVSQFAACNLAQIPPHAVMVRPDT------------------------ 633

  Fly   588 LVDVFALFGEFQKGKKNVYFNDKAVQLTTELKNEIQNEQIYTDL 631
              ::|.::|...|.::........|.|....:.::...:.:.||
Human   634 --NIFTVYGLLDKAQQFAASGTGRVTLPEPSEEQVVCLRCFQDL 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsf1	NP_523401.2	TR_FER	34..323	CDD:214514	84/314 (27%)
		Periplasmic_Binding_Protein_Type_2	384..615	CDD:473866	59/324 (18%)
MELTF	XP_011511152.1	Transferrin	23..357	CDD:395328	91/364 (25%)
		TR_FER	367..733	CDD:214514	62/341 (18%)