DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tsf1 and MELTF

DIOPT Version :9

Sequence 1:NP_001285404.1 Gene:Tsf1 / 32821 FlyBaseID:FBgn0022355 Length:641 Species:Drosophila melanogaster
Sequence 2:XP_011511152.1 Gene:MELTF / 4241 HGNCID:7037 Length:765 Species:Homo sapiens


Alignment Length:759 Identity:164/759 - (21%)
Similarity:277/759 - (36%) Gaps:229/759 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 WLPLAVAALLLILGPQSSLAEEPIYRLCV---PQIYLAECQQLLADPSEAGIR--MECVAGRDRV 69
            ||.|   ||..:||...       .|.|.   |:.:  :|..:.....||||:  :.||.|....
Human     9 WLLL---ALRTVLGGME-------VRWCATSDPEQH--KCGNMSEAFREAGIQPSLLCVRGTSAD 61

  Fly    70 DCLELIEQRKADVLATEPEDMYIAYHRKNEDYR-VISEIRTQQDKDAAFRYEGIILVKKDSPIRT 133
            .|::||..::||.:..:...:|.|  .|....: |:.|:   .|::....|..:.:|::.|.: |
Human    62 HCVQLIAAQEADAITLDGGAIYEA--GKEHGLKPVVGEV---YDQEVGTSYYAVAVVRRSSHV-T 120

  Fly   134 LQQLRGAKSCHTGFGRNVGYKIPITKLKNTHVLKV-SADPQISATERELKSLSEFFTQSCLVGTY 197
            :..|:|.||||||..|.||:.:|:..|..:..|.| ..|        .||::|::|..||:.|..
Human   121 IDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCD--------VLKAVSDYFGGSCVPGAG 177

  Fly   198 STHPETDRLLKKKYA-NLCALCEKPEQ----CNYP--DKFSGYDGAIRCLDKGQGEVAFSKVQYI 255
            .|          .|: :||.||.....    |:..  :::..|.||.|||.:|.|:|||.|...:
Human   178 ET----------SYSESLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAEGAGDVAFVKHSTV 232

  Fly   256 KKYFGLPGAGPDAPPAEGN---PENFEYLCEDGTRRPVT-GPACSWAQRPWSGYISNE------- 309
                 |........|:.|.   .::||.||.||:|..|| ...|..|:.|....:...       
Human   233 -----LENTDGKTLPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVRADTDGGLI 292

  Fly   310 -QAVHNSEQLHQLQSRLERFFANGLQAQN----KDAAAHLLIQPNAVYHS----------KDAAI 359
             :.::..::|...:....:.|::....|.    ||:.:.|:......|.:          |....
Human   293 FRLLNEGQRLFSHEGSSFQMFSSEAYGQKDLLFKDSTSELVPIATQTYEAWLGHEYLHAMKGLLC 357

  Fly   360 DPK---VYLERAGYKDVIERDGSAIRKIRLCAQNDDEFAKCQALHQAAYARDARPELECVQSTD- 420
            ||.   .||                   |.|..:..|..||..:..|...:..:||::||.:.. 
Human   358 DPNRLPPYL-------------------RWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSP 403

  Fly   421 --CVVALTKKEAD-LTIVRATGYADARSNQLQPIVYEQRAQDD-----VLVAVAAPGVTREA--- 474
              |:..:..::.| :|:.....|...::..|.|...|..|.:|     .:|||    |.|::   
Human   404 QHCMERIQAEQVDAVTLSGEDIYTAGKTYGLVPAAGEHYAPEDSSNSYYVVAV----VRRDSSHA 464

  Fly   475 -----------------------------LQKASIK-------------FNENC--------ERS 489
                                         :|:..|:             ||.:|        ..|
Human   465 FTLDELRGKRSCHAGFGSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPS 529

  Fly   490 RAAAALLNKRRGLDACRVSSSDD----------------GEVQIVP----------------ASE 522
            ...|..:...:|.:.| |.:|.:                |:|..|.                |:|
Human   530 SLCALCVGDEQGRNKC-VGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAE 593

  Fly   523 LEKHKDAQLVCPSLERRPVTDFRDCNVDVQLPRAIFIRSDTTSVEQETVKHLFSLISDKFGARGK 587
            | :.:|.:|:||:..|..|:.|..||:....|.|:.:|.||                        
Human   594 L-RSEDYELLCPNGARAEVSQFAACNLAQIPPHAVMVRPDT------------------------ 633

  Fly   588 LVDVFALFGEFQKGKKNVYFNDKAVQLTTELKNEIQNEQIYTDL 631
              ::|.::|...|.::........|.|....:.::...:.:.||
Human   634 --NIFTVYGLLDKAQQFAASGTGRVTLPEPSEEQVVCLRCFQDL 675

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tsf1NP_001285404.1 PBP2_transferrin 34..>302 CDD:270247 82/285 (29%)
Periplasmic_Binding_Protein_Type_2 384..615 CDD:304360 59/324 (18%)
TR_FER 384..614 CDD:214514 59/323 (18%)
MELTFXP_011511152.1 Transferrin 23..357 CDD:278817 91/364 (25%)
PBP2_transferrin 23..355 CDD:270247 91/362 (25%)
TR_FER 367..733 CDD:214514 62/341 (18%)
PBP2_transferrin 367..731 CDD:270247 62/341 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_28KI0
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S7803
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D125278at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
54.730

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