DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsf1 and Tsf3

DIOPT Version :9

Sequence 1:	NP_001285404.1	Gene:	Tsf1 / 32821	FlyBaseID:	FBgn0022355	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_523759.1	Gene:	Tsf3 / 36800	FlyBaseID:	FBgn0034094	Length:	714	Species:	Drosophila melanogaster

Alignment Length:	714	Identity:	176/714 - (24%)
Similarity:	300/714 - (42%)	Gaps:	128/714 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WLPLAVAALLL-ILGPQSSLAEEP----IYRLCVPQ---IYLAE---CQQLLADPSEAGIRMECV 63
            ||.|.:..|.. .|.....:|.:|    ..|:||.:   :|...   |..|     ||...:|||
  Fly     3 WLTLILVGLFASFLSISMCVAVQPPDDGKLRVCVVESRGVYRKTPKFCPLL-----EAKSNIECV 62

  Fly    64 AGRDRVDCLELIEQRKADVLATEPEDMYIAYHRKNEDYRVISEIRTQQDKDAAFRYEGIILVKKD 128
            .|.||:||:..|.:..|.......||: :|....:.:..|.||:|:.   ::.|.||.:.:|...
  Fly    63 IGVDRLDCVRRIHKGTAHFGVLTSEDL-VAARWASVEILVASELRSH---ESHFEYEIVAVVDNH 123

  Fly   129 SPIRTLQQLRGAKSCHTGFGRNVGYKIPITKLKNTHVLKVSADPQISATERELKSLSEFFTQSCL 193
            :.|.|:..||||:.||.|:|....:...:.......::..:.||:::.||..:.|.:::|..||.
  Fly   124 ANIHTVHDLRGARLCHPGYGLGNHWTEVLANYFEAAMVSKTCDPEMTVTEDRIASTAKYFGPSCK 188

  Fly   194 VGTYSTHPETDRLLKKKYANLCALCEKPEQCNYPDKFSGYDGAIRCLDKGQGEVAFSKVQYIKKY 258
            .|.:...|:.||:||.:|.:||.:|.:|:.|:..||..|..||:.||..|.|.||::::..::.:
  Fly   189 AGPWVPDPKQDRILKNRYPSLCEMCYEPDSCDQTDKHWGRRGALYCLTSGGGNVAWARLDDVRSH 253

  Fly   259 FGLPGAGPDAPPAEGNPENFEYLCEDGTRRPV-TGPACSWAQRPWSGYISNEQAVHNSEQLHQLQ 322
            ||..|.     ||:.||.:|.|||.||..:|: ....|.|..:||        .|..:.:.|..|
  Fly   254 FGFSGI-----PAQSNPSDFSYLCPDGHLQPLNASQPCVWVAKPW--------PVVAARRSHAAQ 305

  Fly   323 SRLERFFANGLQAQNKDAAAHLLIQPNAVYHSKDAAIDPKVYLERAGYKDVIERDGSAI------ 381
              ::| ...||.....|:..:.|:.....||.....:|..:.::  .|.|......||.
  Fly   306 --VQR-LVTGLNHDEPDSWQNALLSLLETYHVFTVPLDNVIAID--DYLDQATAFQSAYSFPECN 365

  Fly   382 --RKIRLCAQNDDEFAKCQALHQAAYARDARPELECVQSTD---CVVALTKKEADLTIVRATGYA 441
              |.|..|..:..:..||..|.:|:.....:|.::||::.|   |:.....||.|:.:|......
  Fly   366 PPRSIVFCTTSIIQHIKCSWLQEASQVYGVQPNIQCVRTMDEQQCLDNTKFKETDVVLVDQEMRV 430

  Fly   442 DA-RSNQLQPIVYEQRA-QDDVLVAVAAPGVTREALQKA--SIKFNENCERSRAAAALLNKRRGL 502
            .| |...|.|::||..| ..|..|.:|.  |.::|..::  .:|....|..|...||.|:.:..:
  Fly   431 KAQRDYNLVPLLYEFAADMHDRYVTIAL--VHKDAKFESFRDLKGARACLPSFEGAAHLSVQETI 493

  Fly   503 ----------------DACRVS-----------SSDDGEVQIVP--------ASELEK------- 525
                            |:|..:           ..|:|.::.:.        :|::.|
  Fly   494 VNATGKVQSLHSYFHRDSCLWNLQSGRKCPLHYQGDEGALRCLSEGADVAFLSSDVYKKYVVGNL 558

  Fly   526 ---------HKDAQLVCP--SLERRPVTDFRDCNVDVQLPRAIFIRSDTTSVEQETVKHLFSLIS 579
                     |||.:::||  .:|:|  ::|..|.:. ...|...:..:::...:..:.:....:.
  Fly   559 TSNWLTPGNHKDFRVLCPYGGIEKR--SNFEYCYLH-WTTRGHLMTHNSSLTRRNEIYNSLRDMD 620

  Fly   580 DKFGARGKL-VDVFALFGEFQKGKKNVYF--------------NDKAVQLTTELKNEIQNEQIY 628
            ..||.:.|. ...|.|:|.|.| :.||.|              .|.|.::...:.:...|.|.|
  Fly   621 QLFGRKYKSETRPFTLYGIFDK-RNNVLFRDDTDGLLGLQELHRDNAKRVMEHIYDRYANTQYY 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf1	NP_001285404.1	PBP2_transferrin	34..>302	CDD:270247	86/274 (31%)
		Periplasmic_Binding_Protein_Type_2	384..615	CDD:304360	62/305 (20%)
		TR_FER	384..614	CDD:214514	62/304 (20%)
Tsf3	NP_523759.1	PBP2_transferrin	33..368	CDD:270247	103/361 (29%)
		PBP2_transferrin	369..681	CDD:270247	63/317 (20%)
		TR_FER	370..656	CDD:214514	60/291 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KI0
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D102723at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11485
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920