DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsf1 and RGD1310507

DIOPT Version :9

Sequence 1:	NP_001285404.1	Gene:	Tsf1 / 32821	FlyBaseID:	FBgn0022355	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	XP_038937483.1	Gene:	RGD1310507 / 315963	RGDID:	1310507	Length:	715	Species:	Rattus norvegicus

Alignment Length:	759	Identity:	182/759 - (23%)
Similarity:	289/759 - (38%)	Gaps:	221/759 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LAVAALLLI--LGPQSSLAEEPIY---RLC--VPQIYLAECQQLLADPSEA-------------- 56
            |.|..||.:  |.|.::::....:   |||  ||:..:..|   :....||
  Rat     3 LFVCVLLCVGTLAPVNTVSLPGSHIRNRLCLAVPEKTIRWC---IVSDHEATKCSSFRDNMKKVL 64

  Fly    57 ---GIRMECVAGRDRVDCLELIEQRKADVLATE---PEDMYIAYHRKNEDYRVISEIRTQQDKDA 115
               |..:.||.....::|:..|...|.|.:..:   ..:..:.:|....   :::|....:| |.
  Rat    65 PAGGPAVACVRKTSHLECIRDISANKIDAVTVDGALVAEADLPHHSLKP---IMAEYYGSKD-DP 125

  Fly   116 AFRYEGIILVKKDSPIRTLQQLRGAKSCHTGFGRNVGYKIPITKLKNTHVLKVSADPQISATERE 180
            ...|..:.:|||.:..: |.||:|.||||...|.:.|:.:|::      ||..|...:.:|
  Rat   126 QTHYYVVAVVKKGTGFQ-LNQLQGKKSCHASLGWSAGWYVPLS------VLLPSGSRETAA---- 179

  Fly   181 LKSLSEFFTQSCLVGTYSTHPETDRLLKKKYANLCALCEKPE----QCNYPDKFSGYDGAIRCLD 241
                :.||:.||:       |..|   .|.:..||.||....    .|:..:.:.||.||::||.
  Rat   180 ----ATFFSSSCV-------PCAD---GKMFPRLCQLCSGKGTDKCSCSSGEPYFGYWGALKCLQ 230

  Fly   242 KGQGEVAFSKVQYIKKYFGLPGAGPDAPPAEGNPENFEYLCEDGTRRPVTG-PACSWAQRPWSGY 305
            .|.|:|:|  |:::..:        :..|.:.:.:.:|.||.|.|||||.. ..|..|:.|  .:
  Rat   231 DGTGDVSF--VRHLTVF--------EVMPRKADRDQYELLCPDNTRRPVDEYEQCYLARVP--SH 283

  Fly   306 ISNEQAVHNSEQLHQ--LQSRLERFFANGLQAQNKDAAAHLLIQPNAVYHSK-----DAA----- 358
            :...::|...|...|  |:...|.|      .::|.:...|...|    |.|     |||
  Rat   284 VVVARSVDGKEDSIQELLRVAQEHF------GKDKSSTFQLFGSP----HGKDLLFTDAACGLLR 338

  Fly   359 IDPK----VYLERAGYKDV-----IERDGSAIRKIRLCAQNDDEFAKCQALHQAAYARDARPELE 414
            :.||    :||   ||:.:     ::|.....|:::.||....|.|||.  |.:|.:..|   |.
  Rat   339 VPPKMDIGLYL---GYELLSAIRNLKRGSEDSRRVKWCAVGQQERAKCD--HWSAVSGGA---LA 395

  Fly   415 CVQS---TDCVVALTKKEADLTIVRATGYA----------DARSNQLQPIVYEQRAQDDV----- 461
            |...   .||:.|:.|.|||...:.. |:|          ....|.|.|...|:.....|
  Rat   396 CATEETPEDCIAAVMKGEADAVNLDG-GFAYIAGHCGLVPGLGENYLSPHSSERLGSKCVNAALE 459

  Fly   462 ---LVAVAAP---GVTREAL-------------------------QKASIKFNE----NC----- 486
               :|||...   |:|..:|                         |..|.||:|    .|
  Rat   460 GYYVVAVVKKSDVGITWNSLQGKKSCHTAVGTSAGWNVPMSLIYNQTGSCKFDEFFSGGCAPGAN 524

  Fly   487 -------------ERSRAAAALLNKRRGLDA------CRVSSSD-------------DGEVQIVP 519
                         |.:...||  |...|...      |.|...|             ||:.....
  Rat   525 PDSRLCALCAGGNEPAHMCAA--NNDEGYHGSSGALRCLVEKGDVAFMKHPTVLQNTDGKNPESW 587

  Fly   520 ASELEKHKDAQLVCPSLERRPVTDFRDCNVDVQLPRAIFIRSDTTSVEQETVKHLFSLISDKFGA 584
            |..| ||:|.:|:|....|:|||:.::|::|.....|:|.|.|.....|   :.||:. .:.||.
  Rat   588 AKGL-KHEDFELLCLDGTRKPVTEAQNCHLDRVPNHAVFSRKDKVDFVQ---RMLFNQ-QELFGR 647

  Fly   585 RGKLVDVFALFGEFQKGKKNVYFNDKAVQLTTELKNEIQNEQIY 628
            .|   ..:.:|..|:...|::.|:|     .||..:.:||:..|
  Rat   648 NG---FEYRMFQMFESSHKDLLFSD-----DTECLSNLQNKATY 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf1	NP_001285404.1	PBP2_transferrin	34..>302	CDD:270247	73/297 (25%)
		Periplasmic_Binding_Protein_Type_2	384..615	CDD:304360	75/320 (23%)
		TR_FER	384..614	CDD:214514	75/319 (24%)
RGD1310507	XP_038937483.1	PBP2_transferrin_N	39..361	CDD:270336	89/378 (24%)
RGD1310507	XP_038937483.1	PBP2_transferrin_C	367..699	CDD:270335	81/338 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KI0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11485
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920