DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsf1 and Meltf

DIOPT Version :9

Sequence 1:	NP_001285404.1	Gene:	Tsf1 / 32821	FlyBaseID:	FBgn0022355	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	XP_006522295.1	Gene:	Meltf / 30060	MGIID:	1353421	Length:	758	Species:	Mus musculus

Alignment Length:	760	Identity:	181/760 - (23%)
Similarity:	297/760 - (39%)	Gaps:	196/760 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WLPLAVAALLLILGPQSSLAEEPIYRLCVPQIYLAECQQLLADPSE----AGIR--MECVAGRDR 68
            ||.|::..::.::..|.....:            || ||...|.||    ||||  :.||.|...
Mouse     9 WLLLSLRTVVCVMEVQWCTISD------------AE-QQKCKDMSEAFQGAGIRPSLLCVQGNSA 60

  Fly    69 VDCLELIEQRKADVLATEPEDMYIAYHRKNEDYR-VISEIRTQQDKDAAFRYEGIILVKKDSPIR 132
            ..|::||:::|||.:..:...:|.|  .|....: |:.|:   .|:|....|..:.:|:::|.:
Mouse    61 DHCVQLIKEQKADAITLDGGAIYEA--GKEHGLKPVVGEV---YDQDIGTSYYAVAVVRRNSNV- 119

  Fly   133 TLQQLRGAKSCHTGFGRNVGYKIPITKL-KNTHVLKVSAD--------PQISATERE--LK--SL 184
            |:..|:|.||||||..|.||:.:|:..| ::.|:..:..|        ||..|....  |:  ::
Mouse   120 TINTLKGVKSCHTGINRTVGWNVPVGYLVESGHLSVMGCDVLKALCSVPQPCAPSHSPVLRPTAV 184

  Fly   185 SEFFTQSCLVGTYST-HPETDRLLKKKYANLCALCEKPEQ----CNYP--DKFSGYDGAIRCLDK 242
            .::|..||:.||..| |.|          :||.||.....    |:..  :::..|.||.|||.:
Mouse   185 GDYFGGSCVPGTGETSHSE----------SLCRLCRGDSSGHNVCDKSPLERYYDYSGAFRCLAE 239

  Fly   243 GQGEVAFSKVQYIKKYFGLPGAGPDAPPAEGN---PENFEYLCEDGTRRPVT-GPACSWAQRPWS 303
            |.|:|||.|...:     |.....:..|:.|.   .|:|:.||.||:|..:| ...|..|:.|..
Mouse   240 GAGDVAFVKHSTV-----LENTDGNTLPSWGKSLMSEDFQLLCRDGSRADITEWRRCHLAKVPAH 299

  Fly   304 GYISNE--------QAVHNSEQL--HQLQSRLERFFANGLQAQN---KDAAAHLLIQPNAVYHSK 355
            ..:...        |.::..:.|  |: .|..:.|.:.....:|   ||:...|:  |.|. .:.
Mouse   300 AVVVRGDMDGGLIFQLLNEGQLLFSHE-DSSFQMFSSKAYSQKNLLFKDSTLELV--PIAT-QNY 360

  Fly   356 DAAIDPKVYLERAGYKDVIERDGSAIRKIRLCAQNDDEFAKCQALHQAAYARDARPELECVQSTD 420
            :|.:..: ||:  ..|.::.........:|.|..:..|..||..:..|...::.:||::||.:..
Mouse   361 EAWLGQE-YLQ--AMKGLLCDPNRLPHYLRWCVLSAPEIQKCGDMAVAFSRQNLKPEIQCVSAES 422

  Fly   421 ---CVVALTKKEADLTIVRATG-YADARSNQLQPIVYEQRAQDD-----VLVAVA---------- 466
               |:..:.....|...:|... |...:...|.|...|..|::|     .:||||
Mouse   423 PEHCMEQIQAGHTDAVTLRGEDIYRAGKVYGLVPAAGELYAEEDRSNSYFVVAVARRDSSYSFTL 487

  Fly   467 --------------AP-------------GVTR----EALQKASIKFNENC--------ERSRAA 492
                          :|             |..|    :.|...|..||.:|        ..|...
Mouse   488 DELRGKRSCHPYLGSPAGWEVPIGSLIQRGFIRPKDCDVLTAVSQFFNASCVPVNNPKNYPSALC 552

  Fly   493 AALLNKRRGLDACRVSSSDD----------------GEVQIVP----------------ASELEK 525
            |..:...:|.:.| |.||.:                |:|..|.                ||.| :
Mouse   553 ALCVGDEKGRNKC-VGSSQERYYGYSGAFRCLVEHAGDVAFVKHTTVFENTNGHNPEPWASHL-R 615

  Fly   526 HKDAQLVCPSLERRPVTDFRDCNVDVQLP-RAIFIRSDTTSVEQETVKHLFSLISDKFG----AR 585
            .:|.:|:||:..|..|..|:.||: .|:| .|:.:|.||...   ||..|.....|.||    ..
Mouse   616 WQDYELLCPNGARAEVDQFQACNL-AQMPSHAVMVRPDTNIF---TVYGLLDKAQDLFGDDHNKN 676

  Fly   586 GKLVDVFALFGEFQKGKKNVYFNDKAVQLTTELKNEIQNEQIYTD 630
            |     |.:|...:...:::.|.|..|:..     .::.:..|.|
Mouse   677 G-----FQMFDSSKYHSQDLLFKDATVRAV-----PVREKTTYLD 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf1	NP_001285404.1	PBP2_transferrin	34..>302	CDD:270247	88/298 (30%)
		Periplasmic_Binding_Protein_Type_2	384..615	CDD:304360	71/325 (22%)
		TR_FER	384..614	CDD:214514	71/324 (22%)
Meltf	XP_006522295.1	Transferrin	23..377	CDD:366081	105/394 (27%)
Meltf	XP_006522295.1	TR_FER	387..724	CDD:214514	73/341 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KI0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	140	1.000	Inparanoid score	I4482
Isobase	1	0.950	-	0	Normalized mean entropy	S7803
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.780