DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsf1 and Trf

DIOPT Version :9

Sequence 1:	NP_001285404.1	Gene:	Tsf1 / 32821	FlyBaseID:	FBgn0022355	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_598738.1	Gene:	Trf / 22041	MGIID:	98821	Length:	697	Species:	Mus musculus

Alignment Length:	721	Identity:	173/721 - (23%)
Similarity:	269/721 - (37%)	Gaps:	202/721 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LAVAALLLILGPQSSLAEEPIYRLCVPQIYLAEC------QQLLADPSEAGIRMECVAGRDRVDC 71
            ||.|||.|.|    ::.::.:....|.:....:|      .:.:..|.  |.|:.||......||
Mouse     9 LACAALGLCL----AVPDKTVKWCAVSEHENTKCISFRDHMKTVLPPD--GPRLACVKKTSYPDC 67

  Fly    72 LELIEQRKADVLATEPEDMYIAYHRKNEDYRVISEIRTQQDKDAAFRYEGIILVKKDSPIRTLQQ 136
            ::.|...:||.:..:...:|.|....|....|.:|.....:....: |..:.:|||.:..: |.|
Mouse    68 IKAISASEADAMTLDGGWVYDAGLTPNNLKPVAAEFYGSVEHPQTY-YYAVAVVKKGTDFQ-LNQ 130

  Fly   137 LRGAKSCHTGFGRNVGYKIPITKLKNTHVLKVSADPQISATERELKSLSEFFTQSCLVGTYSTHP 201
            |.|.||||||.||:.|:.|||..|    ..|:| :|: |..|   |::|.||:.||:       |
Mouse   131 LEGKKSCHTGLGRSAGWVIPIGLL----FCKLS-EPR-SPLE---KAVSSFFSGSCV-------P 179

  Fly   202 ETDRLLKKKYANLCALCEKPEQCNYPDKFSGYDGAIRCLDKGQGEVAFSKVQYIKKYFGLPGAGP 266
            ..|.:...|...||..|    .|:....|.||.||.:||..|.|:|||.|...|.:..
Mouse   180 CADPVAFPKLCQLCPGC----GCSSTQPFFGYVGAFKCLKDGGGDVAFVKHTTIFEVL------- 233

  Fly   267 DAPPAEGNPENFEYLCEDGTRRPVTG-PACSWAQRPWSGYISNEQAVHNSEQL--HQLQSRLERF 328
               |.:.:.:.:|.||.|.||:||.. ..|..|:.|....::.:.  :..|.|  ..|:...|.|
Mouse   234 ---PEKADRDQYELLCLDNTRKPVDQYEDCYLARIPSHAVVARKN--NGKEDLIWEILKVAQEHF 293

  Fly   329 ----------FAN--GLQAQNKDAAAHLLIQPNAVYHSKDAAIDPKVYLERAGYKDVIERDGSAI 381
                      |::  |.....||:|..||..|        ..:|.::||   |:..|     :||
Mouse   294 GKGKSKDFQLFSSPLGKDLLFKDSAFGLLRVP--------PRMDYRLYL---GHNYV-----TAI 342

  Fly   382 RK---------------IRLCAQNDDEFAKCQALHQAAYARDARPELECVQST-DCVVALTKKEA 430
            |.               ::.||.:..|..||.   :.:...:.:.|.|..::| ||:..:...||
Mouse   343 RNQQEGVCPEGSIDNSPVKWCALSHLERTKCD---EWSIISEGKIECESAETTEDCIEKIVNGEA 404

  Fly   431 D-LTIVRATGYADARSNQLQPIVYEQRAQDDVLV----AVAAPGVTREALQKAS--------IK- 481
            | :|:.....|...:.. |.|::.|.....:..:    .:...|....|:.|||        :|
Mouse   405 DAMTLDGGHAYIAGQCG-LVPVMAEYYESSNCAIPSQQGIFPKGYYAVAVVKASDTSITWNNLKG 468

  Fly   482 ---------------------------------FNENC----ERSRAAAALL---------NKRR 500
                                             |::.|    |::.....|.         ||..
Mouse   469 KKSCHTGVDRTAGWNIPMGMLYNRINHCKFDEFFSQGCAPGYEKNSTLCDLCIGPLKCAPNNKEE 533

  Fly   501 -----GLDACRVSSSDDGEVQIV-------------PASELE--KHKDAQLVCPSLERRPVTDFR 545
                 |...|.|   :.|:|..|             ||...:  |.:|.:|:||...|:||.||.
Mouse   534 YNGYTGAFRCLV---EKGDVAFVKHQTVLDNTEGKNPAEWAKNLKQEDFELLCPDGTRKPVKDFA 595

  Fly   546 DCNVDVQLPRAIFI-------RSDTTSVEQETVKHLFSLISDKFGARGKLVDVFALFGEFQKGKK 603
            .|:: .|.|..:.:       |.......|||:          ||..    |....|..|:...|
Mouse   596 SCHL-AQAPNHVVVSRKEKAARVKAVLTSQETL----------FGGS----DCTGNFCLFKSTTK 645

  Fly   604 NVYFND 609
            ::.|.|
Mouse   646 DLLFRD 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf1	NP_001285404.1	PBP2_transferrin	34..>302	CDD:270247	81/274 (30%)
		Periplasmic_Binding_Protein_Type_2	384..615	CDD:304360	63/314 (20%)
		TR_FER	384..614	CDD:214514	63/314 (20%)
Trf	NP_598738.1	PBP2_transferrin_N	24..344	CDD:270336	102/371 (27%)
		Transferrin	25..347	CDD:278817	103/373 (28%)
		PBP2_transferrin_C	359..681	CDD:270335	63/315 (20%)
		TR_FER	360..682	CDD:214514	63/314 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KI0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	140	1.000	Inparanoid score	I4482
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11485
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.930