DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment betaCOP and APL1

DIOPT Version :9

Sequence 1:	NP_523400.1	Gene:	betaCOP / 32820	FlyBaseID:	FBgn0008635	Length:	964	Species:	Drosophila melanogaster
Sequence 2:	NP_012538.3	Gene:	APL1 / 853461	SGDID:	S000003765	Length:	700	Species:	Saccharomyces cerevisiae

Alignment Length:	702	Identity:	139/702 - (19%)
Similarity:	253/702 - (36%)	Gaps:	182/702 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 RRNAVLAIFT--IYKNFDWLVPDGPELIASFLDTQQDMSCKR--NAFLMLLHA-DQERALNYLAS 209
            |:||:..|..  :..|:..:.....||: .|...:.|:..||  :.::.::.| ..::|...|..
Yeast    34 RKNALRKIIANLVLGNYGEMSVLFSELL-KFWQIEDDLEVKRICHEYIRVIGALKPQQAREALPF 97

  Fly   210 CIDQVHTFGDILQLVIVELIYKVCHANPAER--SRFIRCIYNLLNSSS--NAVRYESAGTLITLS 270
            .:|...:..:.||::.:..:..|    |.:.  .:...||.:|:|..|  ..|...:...|:.|.
Yeast    98 IMDDFKSRDEKLQIMALRTLVLV----PVKELSDQAFDCIISLVNHKSPPEQVTRTAIYALLDLD 158

  Fly   271 LAPTAIKAAASCYIELVVKESDNNVKLIV--LDRLVAMKE-HEGME--KVMQDLVMDVLRVLAAP 330
            ..........|..:..:||...::.::||  |..|.::.| :..||  ::..:|..|:|.:|  |
Yeast   159 EIDHERVLGLSSILHDIVKAQSSSPEVIVAALHTLYSIHEKNANMEPFRIPLELAFDMLELL--P 221

  Fly   331 DIEVRRKTLALALDLVYSRNIGEMVLVLKKEVAKTHNVEHEDTGKYRQLLVRTLHTC-------S 388
            ::....|...|.              ||...|...|   :.||.:..:|.:..|...       |
Yeast   222 ELNEWNKATVLE--------------VLTTSVVPQH---YLDTHEMIELALPYLQQVNTYVVLNS 269

  Fly   389 IKFPDVAANVIPVLVEFLSD--TNELAAADVLIFIREAIQKFPALRALIIEHLIEAFPQIKSSKI 451
            :||.....|.:.|:.|.|::  :|.:.|         .:.|.|.|:.|::.::|......:||.:
Yeast   270 LKFIMYLLNYVDVIKETLAEKLSNSVIA---------LLDKPPELQFLVLRNVILLLLSRESSLL 325

  Fly   452 HRAAVWILGEYVEGSQI----LEVIAVI--QQTLGEVPMVEAEQRRLAGDQTEEQKQQQGSAGGN 510
            .....:...||.:...|    ||.:.::  ::||   |.:..|..:.|.|...:..::...|.||
Yeast   326 RLDISYFFIEYNDPIYIKDTKLECLYLLANKETL---PRILEELEQYATDIDIQMSRKSVRAIGN 387

  Fly   511 AAGSAAEGSGSGNAS---NKVTSDGTYATQSAYSLAPVAKAEKRPPLRQYLMDGDFFIGAALSAT 572
            .|....|.|.....:   :.:.....|..|...|:.       |..||:|  ..:|      .|.
Yeast   388 LAVKLDEDSVHDCVAVLLDLLEFGVDYVVQEIISVF-------RNILRKY--PNNF------KAN 437

  Fly   573 LTKLALRYAELETEARAQN-------------------------RLTTQVMLIMSSILHLGKSGF 612
            :|:| :::.|:..|..::|                         .:.::.:.:..|||:.....|
Yeast   438 VTEL-VKHTEVVQEPESKNAMIWIITQYSDVIPNYLELFRVFSSNMFSETLEVQFSILNSAIKFF 501

  Fly   613 PSKPITNDDTDRIFVCLRTLS-----ERTPEAISVFTLYCR----------------EALGKMLD 656
            ...|  ..:|:.:  |:..|.     |..|:......:|.|                |:|..:||
Yeast   502 IRSP--TKETEEL--CMDLLKGCIDHENNPDLRDKTLMYWRLLSLTKTSRISNAITFESLKSVLD 562

  Fly   657 AQ-------HDEDQRMLKEKQ-----------KATA--------KVQPDDPVL------------ 683
            .:       ...|..:|:|.:           |..:        |:.|..|:|
Yeast   563 GELPLIEMNTKLDPTVLEELELNIGTIVSIYLKPVSHIFRLNKTKLLPQSPILNPNKDLLPVVGN 627

  Fly   684 -FAQLSNGRDNQLGENVFESSLNQALAGSKNAQLSDVASPNSKLNKVTQLTG 734
             |......||.|..|:  :||..    ..|.|.:.|...|..|:|   ||.|
Yeast   628 SFPPTGANRDRQNSES--QSSTK----SRKTAMMDDYDKPAEKIN---QLKG 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaCOP	NP_523400.1	Adaptin_N	17..562	CDD:279882	92/443 (21%)
		Coatamer_beta_C	678..820	CDD:285019	19/70 (27%)
		Coatomer_b_Cpla	826..953	CDD:291472
APL1	NP_012538.3	COG5096	1..700	CDD:227427	139/702 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810