DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment betaCOP and SEC26

DIOPT Version :9

Sequence 1:	NP_523400.1	Gene:	betaCOP / 32820	FlyBaseID:	FBgn0008635	Length:	964	Species:	Drosophila melanogaster
Sequence 2:	NP_010524.3	Gene:	SEC26 / 851824	SGDID:	S000002646	Length:	973	Species:	Saccharomyces cerevisiae

Alignment Length:	989	Identity:	400/989 - (40%)
Similarity:	622/989 - (62%)	Gaps:	51/989 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SQVPCYTII--NSPDLEVTNEMQLKRDLEKGDTNVKIETLKRVIKLLLNGERYPGLIMTIIRFVL 65
            |..|.||::  .||.:|..:....::.||||....||:|:|.::..:|.|...|.|:|.|||||:
Yeast     5 SSQPAYTLVFDPSPSMETYSSTDFQKALEKGSDEQKIDTMKSILVTMLEGNPMPELLMHIIRFVM 69

  Fly    66 PVQNHTIKKLLLIFWEIVPKTSADGKLLQEMILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPEL 130
            |.:|..:||||..:||||||.:.||||..||||||:|.:.|||||||::||:|||||.||:|.||
Yeast    70 PSKNKELKKLLYFYWEIVPKLAEDGKLRHEMILVCNAIQHDLQHPNEYIRGNTLRFLTKLREAEL 134

  Fly   131 LEPLMPAIRACLDHRHSYVRRNAVLAIFTIYKNFDWLVPDGPELIASFLDTQQDMSCKRNAFLML 195
            ||.::|::.|||::||:|||:.|:||:|:|:|..:.|:||..|:|.||:..:.|..||||||:.|
Yeast   135 LEQMVPSVLACLEYRHAYVRKYAILAVFSIFKVSEHLLPDAKEIINSFIVAETDPICKRNAFIGL 199

  Fly   196 LHADQERALNYLASCIDQVHTFGDILQLVIVELIYKVCHANPAERSRFIRCIYNLLN-SSSNAVR 259
            ...|:|.||:||.:.|..:.....:||.|.|:.|.:..:..||.::::|..:..||: ::|:.|.
Yeast   200 AELDRENALHYLENNIADIENLDPLLQAVFVQFIRQDANRTPALKAQYIELLMELLSTTTSDEVI 264

  Fly   260 YESAGTLITLSLAPTAIKAAASCYIELVVKESDNNVKLIVLDRLVAMKEHEGMEKVMQDLVMDVL 324
            :|:|..|..||..|..:..|.:..|:|.||.||||:|||||||:..:..:.  ...:::|.:|:|
Yeast   265 FETALALTVLSANPNVLVPAVNKLIDLAVKVSDNNIKLIVLDRIQDINANN--VGALEELTLDIL 327

  Fly   325 RVLAAPDIEVRRKTLALALDLVYSRNIGEMVLVLKKEVAKT-HNVEHEDTGKYRQLLVRTLHTCS 388
            |||.|.|::||.|.|.:::||..|||..::|.:||||:..| :|.:.:...:|||||::|:.|.:
Yeast   328 RVLNAEDLDVRSKALDISMDLATSRNAEDVVQLLKKELQTTVNNPDQDKAMQYRQLLIKTIRTVA 392

  Fly   389 IKFPDVAANVIPVLVEFLSDTNELAAADVLIFIREAIQKFPALRALIIEHLIEAFPQIKSSKIHR 453
            :.|.::||:|:.:|::|:.|.|.:||:.::.||:|.|:|:|.|||.|:|::::...:::|:|.:|
Yeast   393 VNFVEMAASVVSLLLDFIGDLNSVAASGIIAFIKEVIEKYPQLRANILENMVQTLDKVRSAKAYR 457

  Fly   454 AAVWILGEYVEG-SQILEVIAVIQQTLGEVPMVEAEQRRLAGDQ--TEEQKQQQGSAGGNAAGSA 515
            .|:||:|||.|| |:|......|:.::||||::::|.::|..:|  |||          |...:.
Yeast   458 GALWIMGEYAEGESEIQHCWKHIRNSVGEVPILQSEIKKLTQNQEHTEE----------NEVDAT 512

  Fly   516 AEGSGSGNASNKVTSDGTYATQSAYSLAPVAKA------EKRPPLRQYLMDGDFFIGAALSATLT 574
            |:.:|.     .:..||||||:||:.:....|:      :.|||:|::::.|||:..|.|:.|:.
Yeast   513 AKPTGP-----VILPDGTYATESAFDVKTSQKSVTDEERDSRPPIRRFVLSGDFYTAAILANTII 572

  Fly   575 KLALRYAELETEARAQNRLTTQVMLIMSSILHLGKSGFPSKPITNDDTDRIFVCLR-TLSERTPE 638
            ||.|::..:.......|.|..:.:||:.||:.:|:|....|.|..|..:|:...:. .|.|..||
Yeast   573 KLVLKFENVSKNKTVINALKAEALLILVSIVRVGQSSLVEKKIDEDSLERVMTSISILLDEVNPE 637

  Fly   639 AIS--------VFTLYCREALGKMLD-AQHDEDQRMLKEKQKATAKVQP-DDPVLFAQLSNGRDN 693
            ...        .|....:.:..:.:: |:.::.:|.||:..|   .::| |.|:.|.|.:.....
Yeast   638 EKKEEVKLLEVAFLDTTKSSFKRQIEIAKKNKHKRALKDSCK---NIEPIDTPISFRQFAGVDST 699

  Fly   694 QLGENVFESSLNQALAGSKNAQLSDVASPNSKLNKVTQLTGFSDPVYAEAYVNVNQYDIVLDVLI 758
            .:.::..|..|..|:.|  :|..:..:|..|||.|:..|.||||||||||.:..||:|:|||||:
Yeast   700 NVQKDSIEEDLQLAMKG--DAIHATSSSSISKLKKIVPLCGFSDPVYAEACITNNQFDVVLDVLL 762

  Fly   759 VNQTNDTLQNCTLELATLGDLKLVERPHPVVLAPHDFCNIKANVKVSSTENGIIFGNIVYETA-- 821
            ||||.:||:|..::.|||||||:::.|....:.||.|......|||||.:.|:|||||:|:.|
Yeast   763 VNQTKETLKNLHVQFATLGDLKIIDTPQKTNVIPHGFHKFTVTVKVSSADTGVIFGNIIYDGAHG 827

  Fly   822 LNTNVVVLNTIHIDIMDYIIPASCTDTEFRQMWQDFEWENKVTVNTSFTDLHEYLKHLLKSTNMK 886
            .:...|:||.:|:||||||.||:..|..||.||..||||||::|.:....||.||:.|:|.|||.
Yeast   828 EDARYVILNDVHVDIMDYIKPATADDEHFRTMWNAFEWENKISVKSQLPTLHAYLRELVKGTNMG 892

  Fly   887 CLTPEKAL-SGQCGFMAANMYAKSIFGENALANLSIEKPVDDPDSKVTGHIRIRAKSQGMALSLG 950
            .|||.::| ...|.|::.|:||||.|||:|||||.|||  |...:.|.|::|||:|.||:|||||
Yeast   893 ILTPSESLGEDDCRFLSCNLYAKSSFGEDALANLCIEK--DSKTNDVIGYVRIRSKGQGLALSLG 955

  Fly   951 DKISSSQKQSVQAA 964
            |:::...|::.:.|
Yeast   956 DRVALIAKKTNKLA 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaCOP	NP_523400.1	Adaptin_N	17..562	CDD:279882	226/555 (41%)
		Coatamer_beta_C	678..820	CDD:285019	64/142 (45%)
		Coatomer_b_Cpla	826..953	CDD:291472	70/127 (55%)
SEC26	NP_010524.3	COG5096	1..941	CDD:227427	386/959 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344421
Domainoid	1	1.000	404	1.000	Domainoid score	I84
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5664
Inparanoid	1	1.050	716	1.000	Inparanoid score	I87
Isobase	1	0.950	-	0	Normalized mean entropy	S39
OMA	1	1.010	-	-		QHG54031
OrthoFinder	1	1.000	-	-		FOG0004277
OrthoInspector	1	1.000	-	-		oto99444
orthoMCL	1	0.900	-	-		OOG6_100064
Panther	1	1.100	-	-	LDO	PTHR10635
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R227
SonicParanoid	1	1.000	-	-		X3011
TreeFam	1	0.960	-	-
	16	15.740