Protein Alignment betaCOP and Ap2b1

DIOPT Version :9

• Sequence 1: NP_523400.1
• Gene: betaCOP / 32820
• FlyBaseID: FBgn0008635
• Length: 964
• Species: Drosophila melanogaster
• Sequence 2: NP_001030931.1
• Gene: Ap2b1 / 71770
• MGIID: 1919020
• Length: 951
• Species: Mus musculus
• Alignment Length: 1058
• Identity: 208/1058 - (19%)
• Similarity: 357/1058 - (33%)
• Gaps: 315/1058 - (29%)

  Fly    19 TNE----MQLKRDLEKGDTNVKIETLKRVIKLLLNGERYPGLIMTIIRFVLPVQNHTIKKLLLIF 79
            ||:    .:||.:|.......:.|.:|:||..:..|:....|...::. .:...|..:|||:.::
Mouse     9 TNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVN-CMQTDNLELKKLVYLY 72

  Fly    80 WEIVPKTSADGKLLQEMILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPELLEPLMPAIRACLDH 144
            .....|:..|     ..|:..:::.||.:.||..:|...:|.:..::..::.|.|...:|.||..
Mouse    73 LMNYAKSQPD-----MAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKD 132

  Fly   145 RHSYVRRNAVLAIFTIYKNFDWLVPDGPELIASFLDTQQDMSCKRNAFLMLLHADQERALNYLAS 209
            ...|||:.|.:.:..::.....:|.|     ..|||:.:|:....|..::   |:...||    |
Mouse   133 EDPYVRKTAAVCVAKLHDINAQMVED-----QGFLDSLRDLIADSNPMVV---ANAVAAL----S 185

  Fly   210 CIDQVHTFGDILQLVIVELIYKVCHANPAERSRFIRCIYN--------LLNSSSN---------- 256
            .|.:.|...::|.|            ||...::.:..:..        :|:..||
Mouse   186 EISESHPNSNLLDL------------NPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQ 238

  Fly   257 ------AVRYESAGTLITLSLAPTAIKAAASCYIELVVKESD----------------------- 292
                  ..|...|.:.:.||.....:|     ::||:.|:||
Mouse   239 SICERVTPRLSHANSAVVLSAVKVLMK-----FLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEV 298

  Fly   293 -----NNVKLIVLDRLVAMKEHEGMEKVMQDLVMDVLRVLAAPDIEVRRKTLALALDLVYSRNIG 352
                 .|:.|||..|...:|:.           :.|..|.....|.|:.:.|.:.:.|....||.
Mouse   299 QYVALRNINLIVQKRPEILKQE-----------IKVFFVKYNDPIYVKLEKLDIMIRLASQANIA 352

  Fly   353 EMVLVLKKEVAKTHNVEHEDTGKYRQLLVRTLHTCSIKFPDVAANVIPVLVEFLSDTNELAAADV 417
            : ||...||.|...:|:      :.:..||.:..|:||....|...:..|::.:.........:.
Mouse   353 Q-VLAELKEYATEVDVD------FVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEA 410

  Fly   418 LIFIREAIQKFPALRALIIEHLIEAFPQIKSSKIHRAAVWILGEYVE----GSQILEVI------ 472
            ::.||:..:|:|.....||..|.|....:.......|.:||:|||.|    ..::||..
Mouse   411 IVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHD 475

  Fly   473 --AVIQQTLGEVPMVEAEQRRLAGDQTEEQKQQQGSAGGNAAGSAAEGSGSGNASNKVTSDGTYA 535
              ..:|.|| ...:|:...::  ..:|:|..||..|.            .:.::.|....|..|.
Mouse   476 ESTQVQLTL-LTAIVKLFLKK--PSETQELVQQVLSL------------ATQDSDNPDLRDRGYI 525

  Fly   536 TQSAYSLAPVAKAE----KRPPLRQYLMDGDFFIGAALSATLTKLALRYAELETEARAQNRLTTQ 596
            .....|..||...|    ::|.:.:                           ||:......|...
Mouse   526 YWRLLSTDPVTAKEVVLSEKPLISE---------------------------ETDLIEPTLLDEL 563

  Fly   597 VMLI--MSSILHL-------GKSGFPSK--PITNDDTDRIFVCLRTLSERTPEAISVFTLYCREA 650
            :..|  ::|:.|.       |..|...|  ||.:..||.....:.|.:....|...|.... .:.
Mouse   564 ICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGTTTTTNLEQPQVIPSQ-GDL 627

  Fly   651 LGKMLDAQHDEDQRMLKEKQKATAKVQPDDPVLFAQLSN-----------GRDNQLGENVFESSL 704
            ||.:|:                   :....||...|:|:           |.|:.||     |.|
Mouse   628 LGDLLN-------------------LDLGPPVNVPQVSSMQMGAVDLLGGGLDSLLG-----SDL 668

  Fly   705 NQALAGSKNAQLSDVASP--------------NSKLNKVTQLT--------GFSDP--VYAEAY- 744
            ...:.||.....|.:.|.              :|.||.:.:|:        |:..|  |:..|.
Mouse   669 GGGIGGSPAVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLPAVK 733

  Fly   745 ---------VNVNQYDIVLDVLIVNQTNDTLQNCTLELATLGDLKLVERPHPVV----LAPHDFC 796
                     ....|..|.::   :|.||..||:.| :.|    ::..:....|:    ||.|...
Mouse   734 AKGLEISGTFTHRQGHIYME---MNFTNKALQHMT-DFA----IQFNKNSFGVIPSTPLAIHTPL 790

  Fly   797 NIKANVKVSSTENGIIFGNIV-YETALNTNVVVLNTIHIDIMDYIIPASCTDTE--------FRQ 852
            ....::.||...|.:  |.:: .|...|..|.|.|.|.:.....:||.:....|        |..
Mouse   791 MPNQSIDVSLPLNTL--GPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLFVEDGKMERQVFLA 853

  Fly   853 MWQDFEWENKV------------TVNTSFTDLHEY------------LKHLLKSTN--------- 884
            .|:|...||::            ||::...:.:.|            |...||.||
Mouse   854 TWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIWILAELR 918

  Fly   885 -----------MKCLTPE 891
                       :||..||
Mouse   919 IQPGNPNYTLSLKCRAPE 936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
betaCOP	NP_523400.1	Adaptin_N	17..562	CDD:279882	124/614 (20%)
		Coatamer_beta_C	678..820	CDD:285019	39/191 (20%)
		Coatomer_b_Cpla	826..953	CDD:291472	24/118 (20%)
Ap2b1	NP_001030931.1	Adaptin_N	11..534	CDD:396262	118/590 (20%)
		HEAT repeat	51..75	CDD:293787	4/24 (17%)
		HEAT repeat	87..114	CDD:293787	6/26 (23%)
		HEAT repeat	121..151	CDD:293787	8/29 (28%)
		HEAT repeat	160..186	CDD:293787	8/32 (25%)
		HEAT repeat	197..228	CDD:293787	5/42 (12%)
		HEAT repeat	392..416	CDD:293787	2/23 (9%)
		HEAT repeat	428..457	CDD:293787	10/28 (36%)
		HEAT repeat	464..494	CDD:293787	6/30 (20%)
		HEAT repeat	505..541	CDD:293787	9/47 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	593..617		5/23 (22%)
		Alpha_adaptinC2	731..831	CDD:197886	24/109 (22%)
		B2-adapt-app_C	840..950	CDD:198088	18/97 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810