DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment betaCOP and Copb1

DIOPT Version :9

Sequence 1:	NP_523400.1	Gene:	betaCOP / 32820	FlyBaseID:	FBgn0008635	Length:	964	Species:	Drosophila melanogaster
Sequence 2:	NP_203534.1	Gene:	Copb1 / 70349	MGIID:	1917599	Length:	953	Species:	Mus musculus

Alignment Length:	964	Identity:	652/964 - (67%)
Similarity:	780/964 - (80%)	Gaps:	30/964 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CYTIINSP-DLEVTNEMQLKRDLEKGDTNVKIETLKRVIKLLLNGERYPGLIMTIIRFVLPVQNH 70
            |||:||.| |.|..:|:.||.||||||...|.|.||:||.::||||:.|||:|||||||||:|:|
Mouse     8 CYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDH 72

  Fly    71 TIKKLLLIFWEIVPKTSADGKLLQEMILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPELLEPLM 135
            |||||||:||||||||:.||:||.|||||||||||||||||||:|||||||||||||.|||||||
Mouse    73 TIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLM 137

  Fly   136 PAIRACLDHRHSYVRRNAVLAIFTIYKNFDWLVPDGPELIASFLDTQQDMSCKRNAFLMLLHADQ 200
            |||||||:||||||||||||||:|||:||:.|:||.||||..||..::|.|||||||:||:||||
Mouse   138 PAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDFLVNEKDASCKRNAFMMLIHADQ 202

  Fly   201 ERALNYLASCIDQVHTFGDILQLVIVELIYKVCHANPAERSRFIRCIYNLLNSSSNAVRYESAGT 265
            :|||:||::|||||.||||||||||||||||||||||:||:||||||||||.|||.||:||:|||
Mouse   203 DRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPSERARFIRCIYNLLQSSSPAVKYEAAGT 267

  Fly   266 LITLSLAPTAIKAAASCYIELVVKESDNNVKLIVLDRLVAMKEHEGMEKVMQDLVMDVLRVLAAP 330
            |:|||.|||||||||.|||:|::||||||||||||||||.:|||...|:|:||||||:||||:.|
Mouse   268 LVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIVLDRLVELKEHPAHERVLQDLVMDILRVLSTP 332

  Fly   331 DIEVRRKTLALALDLVYSRNIGEMVLVLKKEVAKTHNV-EHEDTGKYRQLLVRTLHTCSIKFPDV 394
            |:|||:|||.||||||.|||:.|:|:||||||.||:|| |||||.|||||||||||:||::|||:
Mouse   333 DLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDM 397

  Fly   395 AANVIPVLVEFLSDTNELAAADVLIFIREAIQKFPALRALIIEHLIEAFPQIKSSKIHRAAVWIL 459
            ||||||||:|||||:||.||||||.|:|||||:|..||.||:|.::|.|..|||.||:|.|:|||
Mouse   398 AANVIPVLMEFLSDSNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWIL 462

  Fly   460 GEYVEGSQ-ILEVIAVIQQTLGEVPMVEAEQRRLAGDQTEEQKQQQGSAGGNAAGSAAEGSGSGN 523
            |||....: |..|:..::::|||:|:||:|.::.||:...|::...|.
Mouse   463 GEYCSTKEDIQSVMTEVRRSLGEIPIVESEIKKEAGELKPEEEITVGP----------------- 510

  Fly   524 ASNKVTSDGTYATQSAYSLA-PVAKAEKRPPLRQYLMDGDFFIGAALSATLTKLALRYAELETEA 587
            ....||..||||||||.|.: |..|.|.|||||.:|:|||||:.|:|:.||||:||||..|..|.
Mouse   511 VQKLVTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQEK 575

  Fly   588 RAQNRLTTQVMLIMSSILHLGKSGFPSKPITNDDTDRIFVCLRTLSERTPEAISVFTLYCREALG 652
            :.||....:.||:|::|||||||..|.||||:||.|||.:||:.|||.:|....:|...||::|.
Mouse   576 KKQNSFVAEAMLLMATILHLGKSSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLS 640

  Fly   653 KMLDAQHDEDQ-RMLKEKQKATAKVQPDDPVLFAQLSNGRDNQLGENVFESSLNQALAGSKNAQL 716
            :||.|:.:|:: ...||.:|....||||||:.|.||:...:....|:.|:.||   ||...|.|.
Mouse   641 QMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSL---LAAMGNTQR 702

  Fly   717 SDVASP-NSKLNKVTQLTGFSDPVYAEAYVNVNQYDIVLDVLIVNQTNDTLQNCTLELATLGDLK 780
            .:.|.| .||||||||||||||||||||||:|||||||||||:||||:|||||||||||||||||
Mouse   703 KEAADPLASKLNKVTQLTGFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLK 767

  Fly   781 LVERPHPVVLAPHDFCNIKANVKVSSTENGIIFGNIVYE---TALNTNVVVLNTIHIDIMDYIIP 842
            |||:|.|:.||||||.||||||||:|||||||||||||:   .|.:.|.|||:.|||||||||.|
Mouse   768 LVEKPSPLTLAPHDFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQP 832

  Fly   843 ASCTDTEFRQMWQDFEWENKVTVNTSFTDLHEYLKHLLKSTNMKCLTPEKALSGQCGFMAANMYA 907
            |:|||.||||||.:|||||||||||:.|||::||:|:|||||||||||||||||.|||||||:||
Mouse   833 ATCTDAEFRQMWAEFEWENKVTVNTNMTDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYA 897

  Fly   908 KSIFGENALANLSIEKPV-DDPDSKVTGHIRIRAKSQGMALSLGDKISSSQKQS 960
            :|||||:||||:|||||| ..||:.||||||||||||||||||||||:.|||::
Mouse   898 RSIFGEDALANVSIEKPVHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKT 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaCOP	NP_523400.1	Adaptin_N	17..562	CDD:279882	375/547 (69%)
		Coatamer_beta_C	678..820	CDD:285019	103/145 (71%)
		Coatomer_b_Cpla	826..953	CDD:291472	103/127 (81%)
Copb1	NP_203534.1	Adaptin_N	18..550	CDD:366724	375/548 (68%)
		HEAT 1	96..131		32/34 (94%)
		HEAT 2	132..168		32/35 (91%)
		HEAT repeat	137..161	CDD:293787	22/23 (96%)
		HEAT repeat	173..211	CDD:293787	25/37 (68%)
		HEAT repeat	221..272	CDD:293787	43/50 (86%)
		HEAT 3	240..276		27/35 (77%)
		HEAT 4	277..314		29/36 (81%)
		HEAT repeat	280..307	CDD:293787	22/26 (85%)
		HEAT 5	316..353		27/36 (75%)
		HEAT repeat	318..342	CDD:293787	17/23 (74%)
		HEAT 6	396..433		29/36 (81%)
		Coatamer_beta_C	667..807	CDD:369484	103/142 (73%)
		Coatomer_b_Cpla	813..944	CDD:373307	104/130 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839808
Domainoid	1	1.000	708	1.000	Domainoid score	I120
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5664
Inparanoid	1	1.050	1265	1.000	Inparanoid score	I170
Isobase	1	0.950	-	0	Normalized mean entropy	S39
OMA	1	1.010	-	-		QHG54031
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004277
OrthoInspector	1	1.000	-	-		oto93110
orthoMCL	1	0.900	-	-		OOG6_100064
Panther	1	1.100	-	-	LDO	PTHR10635
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R227
SonicParanoid	1	1.000	-	-		X3011
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740