Protein Alignment betaCOP and Copb1

DIOPT Version :10

• Sequence 1: NP_523400.1
• Gene: betaCOP / 32820
• FlyBaseID: FBgn0008635
• Length: 964
• Species: Drosophila melanogaster
• Sequence 2: NP_203534.1
• Gene: Copb1 / 70349
• MGIID: 1917599
• Length: 953
• Species: Mus musculus
• Alignment Length: 964
• Identity: 652/964 - (67%)
• Similarity: 780/964 - (80%)
• Gaps: 30/964 - (3%)

  Fly     7 CYTIINSP-DLEVTNEMQLKRDLEKGDTNVKIETLKRVIKLLLNGERYPGLIMTIIRFVLPVQNH 70
            |||:||.| |.|..:|:.||.||||||...|.|.||:||.::||||:.|||:|||||||||:|:|
Mouse     8 CYTLINVPMDSEPPSEISLKNDLEKGDVKSKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDH 72

  Fly    71 TIKKLLLIFWEIVPKTSADGKLLQEMILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPELLEPLM 135
            |||||||:||||||||:.||:||.|||||||||||||||||||:|||||||||||||.|||||||
Mouse    73 TIKKLLLVFWEIVPKTTPDGRLLHEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLM 137

  Fly   136 PAIRACLDHRHSYVRRNAVLAIFTIYKNFDWLVPDGPELIASFLDTQQDMSCKRNAFLMLLHADQ 200
            |||||||:||||||||||||||:|||:||:.|:||.||||..||..::|.|||||||:||:||||
Mouse   138 PAIRACLEHRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDFLVNEKDASCKRNAFMMLIHADQ 202

  Fly   201 ERALNYLASCIDQVHTFGDILQLVIVELIYKVCHANPAERSRFIRCIYNLLNSSSNAVRYESAGT 265
            :|||:||::|||||.||||||||||||||||||||||:||:||||||||||.|||.||:||:|||
Mouse   203 DRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPSERARFIRCIYNLLQSSSPAVKYEAAGT 267

  Fly   266 LITLSLAPTAIKAAASCYIELVVKESDNNVKLIVLDRLVAMKEHEGMEKVMQDLVMDVLRVLAAP 330
            |:|||.|||||||||.|||:|::||||||||||||||||.:|||...|:|:||||||:||||:.|
Mouse   268 LVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIVLDRLVELKEHPAHERVLQDLVMDILRVLSTP 332

  Fly   331 DIEVRRKTLALALDLVYSRNIGEMVLVLKKEVAKTHNV-EHEDTGKYRQLLVRTLHTCSIKFPDV 394
            |:|||:|||.||||||.|||:.|:|:||||||.||:|| |||||.|||||||||||:||::|||:
Mouse   333 DLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDM 397

  Fly   395 AANVIPVLVEFLSDTNELAAADVLIFIREAIQKFPALRALIIEHLIEAFPQIKSSKIHRAAVWIL 459
            ||||||||:|||||:||.||||||.|:|||||:|..||.||:|.::|.|..|||.||:|.|:|||
Mouse   398 AANVIPVLMEFLSDSNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGALWIL 462

  Fly   460 GEYVEGSQ-ILEVIAVIQQTLGEVPMVEAEQRRLAGDQTEEQKQQQGSAGGNAAGSAAEGSGSGN 523
            |||....: |..|:..::::|||:|:||:|.::.||:...|::...|.
Mouse   463 GEYCSTKEDIQSVMTEVRRSLGEIPIVESEIKKEAGELKPEEEITVGP----------------- 510

  Fly   524 ASNKVTSDGTYATQSAYSLA-PVAKAEKRPPLRQYLMDGDFFIGAALSATLTKLALRYAELETEA 587
            ....||..||||||||.|.: |..|.|.|||||.:|:|||||:.|:|:.||||:||||..|..|.
Mouse   511 VQKLVTEMGTYATQSALSSSRPTKKEEDRPPLRGFLLDGDFFVAASLATTLTKIALRYVALVQEK 575

  Fly   588 RAQNRLTTQVMLIMSSILHLGKSGFPSKPITNDDTDRIFVCLRTLSERTPEAISVFTLYCREALG 652
            :.||....:.||:|::|||||||..|.||||:||.|||.:||:.|||.:|....:|...||::|.
Mouse   576 KKQNSFVAEAMLLMATILHLGKSSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRQSLS 640

  Fly   653 KMLDAQHDEDQ-RMLKEKQKATAKVQPDDPVLFAQLSNGRDNQLGENVFESSLNQALAGSKNAQL 716
            :||.|:.:|:: ...||.:|....||||||:.|.||:...:....|:.|:.||   ||...|.|.
Mouse   641 QMLSAKLEEEKLSQKKESEKRNVTVQPDDPISFMQLTAKNEMNCKEDQFQLSL---LAAMGNTQR 702

  Fly   717 SDVASP-NSKLNKVTQLTGFSDPVYAEAYVNVNQYDIVLDVLIVNQTNDTLQNCTLELATLGDLK 780
            .:.|.| .||||||||||||||||||||||:|||||||||||:||||:|||||||||||||||||
Mouse   703 KEAADPLASKLNKVTQLTGFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLK 767

  Fly   781 LVERPHPVVLAPHDFCNIKANVKVSSTENGIIFGNIVYE---TALNTNVVVLNTIHIDIMDYIIP 842
            |||:|.|:.||||||.||||||||:|||||||||||||:   .|.:.|.|||:.|||||||||.|
Mouse   768 LVEKPSPLTLAPHDFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQP 832

  Fly   843 ASCTDTEFRQMWQDFEWENKVTVNTSFTDLHEYLKHLLKSTNMKCLTPEKALSGQCGFMAANMYA 907
            |:|||.||||||.:|||||||||||:.|||::||:|:|||||||||||||||||.|||||||:||
Mouse   833 ATCTDAEFRQMWAEFEWENKVTVNTNMTDLNDYLQHILKSTNMKCLTPEKALSGYCGFMAANLYA 897

  Fly   908 KSIFGENALANLSIEKPV-DDPDSKVTGHIRIRAKSQGMALSLGDKISSSQKQS 960
            :|||||:||||:|||||| ..||:.||||||||||||||||||||||:.|||::
Mouse   898 RSIFGEDALANVSIEKPVHQGPDAAVTGHIRIRAKSQGMALSLGDKINLSQKKT 951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
betaCOP	NP_523400.1	Adaptin_N	17..562	CDD:396262	375/547 (69%)
		Coatamer_beta_C	678..819	CDD:462245	102/141 (72%)
		Coatomer_b_Cpla	825..953	CDD:434227	104/128 (81%)
Copb1	NP_203534.1	Adaptin_N	18..550	CDD:396262	375/548 (68%)
		HEAT 1	96..131		32/34 (94%)
		HEAT 2	132..168		32/35 (91%)
		HEAT repeat	137..161	CDD:293787	22/23 (96%)
		HEAT repeat	173..211	CDD:293787	25/37 (68%)
		HEAT repeat	221..272	CDD:293787	43/50 (86%)
		HEAT 3	240..276		27/35 (77%)
		HEAT 4	277..314		29/36 (81%)
		HEAT repeat	280..307	CDD:293787	22/26 (85%)
		HEAT 5	316..353		27/36 (75%)
		HEAT repeat	318..342	CDD:293787	17/23 (74%)
		HEAT 6	396..433		29/36 (81%)
		Coatamer_beta_C	667..807	CDD:462245	103/142 (73%)
		Coatomer_b_Cpla	813..944	CDD:434227	104/130 (80%)