Protein Alignment betaCOP and ap3b1a

DIOPT Version :9

• Sequence 1: NP_523400.1
• Gene: betaCOP / 32820
• FlyBaseID: FBgn0008635
• Length: 964
• Species: Drosophila melanogaster
• Sequence 2: XP_021324676.1
• Gene: ap3b1a / 563316
• ZFINID: ZDB-GENE-031112-8
• Length: 1111
• Species: Danio rerio
• Alignment Length: 1117
• Identity: 220/1117 - (19%)
• Similarity: 404/1117 - (36%)
• Gaps: 285/1117 - (25%)

  Fly    20 NEMQLKRDLEKGDTNVKIETLKRVIKLLLNGERYPGLIMTIIRFVLPVQNHTIKKLLLIFWEIVP 84
            || .||..||....::|:|.:|||:.|:.||:....|...:::.|.. :|..:|||:.::.....
Zfish    52 NE-DLKEMLESNKESLKLEAMKRVVGLIANGKNASELFPAVVKNVAS-KNIELKKLVYVYLVRYA 114

  Fly    85 KTSADGKLLQEMILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPELLEPLMPAIRACLDHRHSYV 149
            :...|..||.     ...:::.|:.||:.:|.|.||.|..::.|.::..:|.||:........||
Zfish   115 EEQQDLALLS-----ISTFQRALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAATDLSPYV 174

  Fly   150 RRNAVLAIFTIY-----------KNFDWLVPDGPELIASFLDTQQDMSCKRNAFLMLLHADQERA 203
            |:.|..||..:|           :..:.|:.|...|:|..:....:..|...  :.|:|.:..:.
Zfish   175 RKTAAHAIQKLYSLDPDQKEHLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDR--IDLIHKNYRKL 237

  Fly   204 LNYLASCIDQVHTFGDILQLVIVELIYKVCHANPAERSRFI--------------RCIYN----- 249
            .|.|.    .|..:|   |:||:.::.:..      |::||              :..|:
Zfish   238 CNLLV----DVEEWG---QVVIIHMLTRYA------RTQFISPWREDAIFDENSEKTFYDSEEER 289

  Fly   250 ----------------LLNSSSNAVRYESAGTLITLSLAPTAIKAAASCYIELVVK------ESD 292
                            ||.::...:  :|..|.:.:::.......|....|.::.|      .|.
Zfish   290 RVDQSKPYIMDPDHRLLLRNTKPLL--QSRNTAVVMAVCQLYWHLAPKHEISIITKSLVRLLRSH 352

  Fly   293 NNVKLIVLDRLVAMK-EHEGM-EKVMQDLVMDVLRVLAAPDIEVRRKTLALALDLVYSRNIGEMV 355
            ..|:.:||..:..|. :.:|| |..|:..   .:|...|..|    |||.|.: |....|...:.
Zfish   353 REVQYVVLQNIATMSIQRKGMFEPFMKSF---YVRSTDATHI----KTLKLEI-LTNLANEANIS 409

  Fly   356 LVLKKEVAKTHNVEHEDTGKYRQLLVRTLHTCSIKFPDVAANVIPVLVEFLSDTNELAAADVLIF 420
            .:|::  .:|: |:.:|.. :....::.:..|:....:|....:..||..||:.:|...|:.::.
Zfish   410 TILRE--FQTY-VKSQDKA-FAAATIQAIGRCATNISEVTDTCLNGLVLLLSNRDETVVAESVVV 470

  Fly   421 IREAIQKFPALRALIIEHLIEAFPQIKSSKIHRAAVWILGEYVEGSQILEVIAVIQQTLGEVPMV 485
            |::.:|..|:..:.||:|:.:.|..|.......:.:|::|||.|                .||.:
Zfish   471 IKKLLQTQPSQHSDIIKHMAKLFDNITVPMARASILWLMGEYCE----------------HVPKI 519

  Fly   486 EAE-QRRLAGDQTEEQ---KQQQGSAGGNAAGSAAEGSGSGNASNKVTSD-----GTY------- 534
            ..: .|::|...|.|:   |.|       ....||:...:.:...|:.:.     |.|
Zfish   520 APDVLRKMAKSFTSEEDIVKLQ-------TVNLAAKLYLTNSKQTKLLTQYILNLGKYDQNYDIR 577

  Fly   535 ----------------ATQSAYSLAPVAKAEKRPPLRQYLMDGDFFIGAALSATLTKLALRYAEL 583
                            ...|.|:...:...:..|.|:....|.|.:....||.||...|..|.||
Zfish   578 DRTRFIRQLIVPNEKSGALSKYARRILMAPKPAPVLQSAFKDRDRYQLGTLSHTLNSQATGYLEL 642

  Fly   584 -ETEARAQNRLTTQVMLI----MSSILHLGKS--GFPSKPITNDDTDR--------------IFV 627
             :..|.|.::....|.::    .|....||||  |...:...:|:.:.              ...
Zfish   643 SDWPAAAPDQSVRNVEVVEPVKESGAPSLGKSKAGKSKEKFYSDEEEEEEEEDEESNSEDSSSSS 707

  Fly   628 CLRTLSERTPEAISVFTLYCREALGKMLDAQHDEDQRMLKEKQKATAKVQPDDPVLFAQLSNGRD 692
            ...:.|....|..|..:.....:..:...::.|.|::...:|.|...:.:||        |..|.
Zfish   708 SEESESGSESEENSEVSNKSSSSQSEKSSSESDSDKKKKTQKNKKIQQQKPD--------SKNRK 764

  Fly   693 NQLGENVFESSLNQALAGS---------------------------------------------- 711
            .:.|......|.:::.:||
Zfish   765 QKNGNAGKSESRSESESGSGSSSSESSSDSGSESGSELESDSDSGTDQKKNTKSKPVQSKPVVKQ 829

  Fly   712 ---KNAQLSD--------VASPNSKL---NKVTQLTGFS-DPVYA-----EAYVNVNQYDIVLDV 756
               |...|.|        |.:|.|.:   :.::.|.|.| .|..|     ..:|....|:::..:
Zfish   830 VEKKEVSLLDLDDFAPTPVTTPKSSILSPSLLSDLQGLSISPTSALQASSPVFVPETSYELLHRM 894

  Fly   757 L---IVNQTNDTLQNCTLELATLGDLKLV-----ERPHPVVLAPHDFCNIKANVKVSSTENGIIF 813
            .   :..|...|.|.|..: :::..|:|.     |:|         ..||..:.|.||.:|...|
Zfish   895 TGKGLSGQYRFTRQPCIYD-SSMVSLQLTLSNSSEQP---------LENIHISQKSSSAQNIHCF 949

  Fly   814 GNIVYETALNTNVVVLNTIHIDIMDYIIPAS---CT-DTEFRQMWQDFEWENKVTVNTSFTDLHE 874
             |.|.......:|.|  :|.::..|....|:   || :.||....|....|..:.|:.|..|...
Zfish   950 -NAVERLEPQASVTV--SIGVNFNDSTQAANFQLCTKEDEFSVSIQPAVGELLLPVSMSEADFTR 1011

  Fly   875 YLKHLL---KSTNMKCLTPEKALS----------GQCGFMAA-----NMYAKSIFGENALANLSI 921
            ....||   :|:....::||...|          ...|.:::     :.:|......::|..:|:
Zfish  1012 EQGKLLGMNESSATITMSPENISSQSVSRKVVSVANLGVISSTQENIHRFAGKTVSSSSLVLVSV 1076

  Fly   922 EKPVDDPDSKVT 933
              .:.|||:::|
Zfish  1077 --TLKDPDAQIT 1086

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
betaCOP	NP_523400.1	Adaptin_N	17..562	CDD:279882	128/627 (20%)
		Coatamer_beta_C	678..820	CDD:285019	38/215 (18%)
		Coatomer_b_Cpla	826..953	CDD:291472	28/130 (22%)
ap3b1a	XP_021324676.1	Adaptin_N	54..587	CDD:307641	121/590 (21%)
		HEAT repeat	124..152	CDD:293787	8/32 (25%)
		HEAT repeat	158..186	CDD:293787	9/27 (33%)
		HEAT repeat	195..221	CDD:293787	4/25 (16%)
		AP3B1_C	832..974	CDD:317233	34/154 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910