Protein Alignment betaCOP and ap2b1

DIOPT Version :9

• Sequence 1: NP_523400.1
• Gene: betaCOP / 32820
• FlyBaseID: FBgn0008635
• Length: 964
• Species: Drosophila melanogaster
• Sequence 2: XP_012812114.1
• Gene: ap2b1 / 394814
• XenbaseID: XB-GENE-5871354
• Length: 958
• Species: Xenopus tropicalis
• Alignment Length: 1081
• Identity: 204/1081 - (18%)
• Similarity: 350/1081 - (32%)
• Gaps: 354/1081 - (32%)

  Fly    19 TNE----MQLKRDLEKGDTNVKIETLKRVIKLLLNGERYPGLIMTIIRFVLPVQNHTIKKLLLIF 79
            ||:    .:||.:|.......:.|.:|:||..:..|:....|...::. .:...|..:|||:.::
 Frog     9 TNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVN-CMQTDNLELKKLVYLY 72

  Fly    80 WEIVPKTSADGKLLQEMILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPELLEPLMPAIRACLDH 144
            .....|:..|     ..|:..:::.||.:.||..:|...:|.:..::..::.|.|...:|.||..
 Frog    73 LMNYAKSQPD-----MAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKD 132

  Fly   145 RHSYVRRNAVLAIFTIYKNFDWLVPDGPELIASFLDTQQDMSCKRNAFLMLLHADQERALNYLAS 209
            ...|||:.|.:.:..::.....:|.|     ..|||:.:|:....|..::   |:...||    |
 Frog   133 EDPYVRKTAAVCVAKLHDINAQMVED-----QGFLDSLRDLIADSNPMVV---ANAVAAL----S 185

  Fly   210 CIDQVHTFGDILQLVIVELIYKVCHANPAERSRFIRCIYN--------LLNSSSN---------- 256
            .|.:.|...::|.|            ||...::.:..:..        :|:..||
 Frog   186 EISESHPNSNLLDL------------NPQNINKLLTALNECTEWGQIFILDCLSNYNPKDEREAQ 238

  Fly   257 ------AVRYESAGTLITLSLAPTAIKAAASCYIELVVKESD----------------------- 292
                  ..|...|.:.:.||.....:|     ::||:.|:||
 Frog   239 SICERVTPRLSHANSAVVLSAVKVLMK-----FLELLPKDSDYYTMLLKKLAPPLVTLLSGEPEV 298

  Fly   293 -----NNVKLIVLDRLVAMKEHEGMEKVMQDLVMDVLRVLAAPDIEVRRKTLALALDLVYSRNIG 352
                 .|:.|||..|...:|:.           :.|..|.....|.|:.:.|.:.:.|....||.
 Frog   299 QYVALRNINLIVQKRPEILKQE-----------IKVFFVKYNDPIYVKLEKLDIMIRLASQANIA 352

  Fly   353 EMVLVLKKEVAKTHNVEHEDTGKYRQLLVRTLHTCSIKFPDVAANVIPVLVEFLSDTNELAAADV 417
            : ||...||.|...:|:      :.:..||.:..|:||....|...:..|::.:.........:.
 Frog   353 Q-VLAELKEYATEVDVD------FVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEA 410

  Fly   418 LIFIREAIQKFPALRALIIEHLIEAFPQIKSSKIHRAAVWILGEYVE----GSQILEVI------ 472
            ::.||:..:|:|.....||..|.|....:.......|.:||:|||.|    ..::||..
 Frog   411 IVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARGAMIWIVGEYAERIDNADELLESFLEGFHD 475

  Fly   473 --AVIQQTLGEVPMVEAEQRRLAGDQTEEQKQQQGSAGGNAAGSAAEGSGSGNASNK-------V 528
              ..:|.|| ...:|:...::  ..:|:|..||       ....|.:.|.:.:..::       :
 Frog   476 ESTQVQLTL-LTAIVKLFLKK--PSETQELVQQ-------VLSLATQDSDNPDLRDRGYIYWRLL 530

  Fly   529 TSDGTYATQSAYSLAPVAKAE---------------------------------------KRPPL 554
            ::|...|.:...|..|:...|                                       |..|:
 Frog   531 STDPVTAKEVVLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGVHRKHLPI 595

  Fly   555 RQYLMD-GDFFIGAALSATLTKLALRYAELETEARAQNRLTTQVMLIMSSILHLGKSGFPSKPIT 618
            :...:| ||..:|...||.|        |......:|..|...::     .|.||..|
 Frog   596 QHGSIDIGDSPVGPTPSAGL--------EQPQVIPSQGDLLGDLL-----NLDLGPPG------- 640

  Fly   619 NDDTDRIFVCLRTLSERTPEAISVFTLYCREALGKMLDAQHDED-------------------QR 664
                            ..|: :|...:...:.||..||:...||                   |.
 Frog   641 ----------------NVPQ-VSTMQMGAVDLLGGGLDSLMGEDTQWLGSDLGGGIGGSPAVGQT 688

  Fly   665 MLKEKQKATAKVQPDDPVLFA------QLSNGRDNQLGENVFESSLNQALAGSKNAQLSDVASPN 723
            .:.....||....|...|:.:      :||:|.....|..|.:.::......:|..::|...|..
 Frog   689 FIPSSVPATFAPSPTPAVVSSGLNDLFELSSGIGMAPGGYVSQKAVWLPAVKAKGLEISGTFSHR 753

  Fly   724 --------SKLNKVTQ-LTGFSDPVYAEAYVNVNQYDIVLDV-------LIVNQTNDTLQNCTLE 772
                    |..||..| :|.|:      ...|.|.:.::...       |:.||:.|    .:|.
 Frog   754 QAHIYMDMSFTNKALQHMTDFA------IQFNKNSFGVIPSAPLAIHTPLMPNQSID----ISLP 808

  Fly   773 LATLGDLKLVERPHPVVLAPHDFCNIKANVKVSSTENGIIFGNIVYETALNTNVVVLNTIHIDIM 837
            |.|||         ||                           :..|...|..|.|.|.|.:...
 Frog   809 LNTLG---------PV---------------------------MKMEPLNNLQVAVKNNIDVFYF 837

  Fly   838 DYIIPASCTDTE--------FRQMWQDFEWENKV------------TVNTSFTDLHEY------- 875
            ..:||......|        |...|:|...||::            ||::...:.:.|
 Frog   838 SCLIPLHVLFVEDGKMERQVFLATWKDIPNENELQFQIKDCHLNADTVSSKLQNNNVYTIAKRNV 902

  Fly   876 -----LKHLLKSTN--------------------MKCLTPE 891
                 |...||.||                    :||..||
 Frog   903 EGQDMLYQSLKLTNGIWILAELRIQPGNPNYTLSLKCRAPE 943

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
betaCOP	NP_523400.1	Adaptin_N	17..562	CDD:279882	125/657 (19%)
		Coatamer_beta_C	678..820	CDD:285019	29/163 (18%)
		Coatomer_b_Cpla	826..953	CDD:291472	24/118 (20%)
ap2b1	XP_012812114.1	Adaptin_N	11..534	CDD:366724	115/585 (20%)
		HEAT repeat	51..75	CDD:293787	4/24 (17%)
		HEAT repeat	87..114	CDD:293787	6/26 (23%)
		HEAT repeat	121..151	CDD:293787	8/29 (28%)
		HEAT repeat	160..186	CDD:293787	8/32 (25%)
		HEAT repeat	197..228	CDD:293787	5/42 (12%)
		HEAT repeat	392..416	CDD:293787	2/23 (9%)
		HEAT repeat	428..457	CDD:293787	10/28 (36%)
		HEAT repeat	464..494	CDD:293787	6/30 (20%)
		HEAT repeat	505..541	CDD:293787	5/42 (12%)
		Alpha_adaptinC2	738..838	CDD:197886	28/145 (19%)
		B2-adapt-app_C	847..957	CDD:198088	18/97 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910