DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment betaCOP and copb1

DIOPT Version :9

Sequence 1:	NP_523400.1	Gene:	betaCOP / 32820	FlyBaseID:	FBgn0008635	Length:	964	Species:	Drosophila melanogaster
Sequence 2:	NP_001002013.1	Gene:	copb1 / 338138	ZFINID:	ZDB-GENE-030219-38	Length:	953	Species:	Danio rerio

Alignment Length:	964	Identity:	647/964 - (67%)
Similarity:	772/964 - (80%)	Gaps:	30/964 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CYTIIN-SPDLEVTNEMQLKRDLEKGDTNVKIETLKRVIKLLLNGERYPGLIMTIIRFVLPVQNH 70
            |||:|| :.|.|..:|:.||.|||||:...|.|.||:||.::||||:.|||:|||||||||:|:|
Zfish     8 CYTLINVTNDSEPPSEVSLKTDLEKGEIKAKTEALKKVIIMILNGEKLPGLLMTIIRFVLPLQDH 72

  Fly    71 TIKKLLLIFWEIVPKTSADGKLLQEMILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPELLEPLM 135
            |||||||:||||||||:.|||||||||||||||||||||||||:|||||||||||||.|||||||
Zfish    73 TIKKLLLVFWEIVPKTTPDGKLLQEMILVCDAYRKDLQHPNEFIRGSTLRFLCKLKESELLEPLM 137

  Fly   136 PAIRACLDHRHSYVRRNAVLAIFTIYKNFDWLVPDGPELIASFLDTQQDMSCKRNAFLMLLHADQ 200
            |||||||:.|||||||||||||:|||:||:.|:||.||||..||..::|.|||||||:||:||||
Zfish   138 PAIRACLERRHSYVRRNAVLAIYTIYRNFEHLIPDAPELIHDFLVNEKDASCKRNAFMMLIHADQ 202

  Fly   201 ERALNYLASCIDQVHTFGDILQLVIVELIYKVCHANPAERSRFIRCIYNLLNSSSNAVRYESAGT 265
            :|||:||::||||||||||||||||||||||||||||:||:||||||||||.|||.||:||:|||
Zfish   203 DRALDYLSTCIDQVHTFGDILQLVIVELIYKVCHANPSERARFIRCIYNLLQSSSPAVKYEAAGT 267

  Fly   266 LITLSLAPTAIKAAASCYIELVVKESDNNVKLIVLDRLVAMKEHEGMEKVMQDLVMDVLRVLAAP 330
            |:|||.|||||||||.|||:|::|||||||||||||||:.:|||...|:|:||||||:||||..|
Zfish   268 LVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIVLDRLIELKEHPTHERVLQDLVMDILRVLTTP 332

  Fly   331 DIEVRRKTLALALDLVYSRNIGEMVLVLKKEVAKTHNV-EHEDTGKYRQLLVRTLHTCSIKFPDV 394
            |:|||:|||.||||||.|||:.|:|:||||||.||:|| |||||.|||||||||||:||::|||:
Zfish   333 DLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVTEHEDTDKYRQLLVRTLHSCSVRFPDM 397

  Fly   395 AANVIPVLVEFLSDTNELAAADVLIFIREAIQKFPALRALIIEHLIEAFPQIKSSKIHRAAVWIL 459
            ||||||||:||||||||.||||||.|:|||||:|..||.||||.::|.|..||:.||:|.|:|||
Zfish   398 AANVIPVLMEFLSDTNEAAAADVLEFVREAIQRFDNLRPLIIEKMLEVFHAIKTVKIYRGALWIL 462

  Fly   460 GEYVEGSQ-ILEVIAVIQQTLGEVPMVEAEQRRLAGDQTEEQKQQQGSAGGNAAGSAAEGSGSGN 523
            |||....: |..|:..::::|||:|:||.|.::.||:...|::.           :||.
Zfish   463 GEYCSTKEDIQSVMTEVRRSLGEIPIVENELKKEAGEVKPEEEV-----------TAAP------ 510

  Fly   524 ASNKVTSDGTYATQSAYSLA-PVAKAEKRPPLRQYLMDGDFFIGAALSATLTKLALRYAELETEA 587
            |...||..|||.||||.|.: |..|.|.|||||.:||||||::.|:|:.||||:||||..|..:.
Zfish   511 APKLVTEMGTYVTQSALSTSRPSKKEEDRPPLRGFLMDGDFYVAASLATTLTKVALRYVALAEDK 575

  Fly   588 RAQNRLTTQVMLIMSSILHLGKSGFPSKPITNDDTDRIFVCLRTLSERTPEAISVFTLYCREALG 652
            |.||....:.||||:::||||||..|.||||:||.|||.:||:.|||.:|....:|...||.:|.
Zfish   576 RRQNSFVAEAMLIMATVLHLGKSSLPKKPITDDDVDRISLCLKVLSECSPLMNDIFNKECRRSLS 640

  Fly   653 KMLDAQHDEDQ-RMLKEKQKATAKVQPDDPVLFAQLSNGRDNQLGENVFESSLNQALAGSKNAQL 716
            .||..:.:|:: ...||.:|....||.|||:.|.||:...:....|:.|:.||   ||...|.|.
Zfish   641 HMLAVRLEEEKLSQKKESEKRNVTVQADDPISFMQLTAKNEMASKEDQFQLSL---LAAMGNTQR 702

  Fly   717 SDVASP-NSKLNKVTQLTGFSDPVYAEAYVNVNQYDIVLDVLIVNQTNDTLQNCTLELATLGDLK 780
            .:...| .||||||||||||||||||||||:|||||||||||:||||:|||||||||||||||||
Zfish   703 KEATDPLASKLNKVTQLTGFSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLK 767

  Fly   781 LVERPHPVVLAPHDFCNIKANVKVSSTENGIIFGNIVYE---TALNTNVVVLNTIHIDIMDYIIP 842
            |||:|.|:.||||||.||||||||:|||||||||||||:   .|.:.|.|||:.|||||||||.|
Zfish   768 LVEKPSPLTLAPHDFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVVLSDIHIDIMDYIQP 832

  Fly   843 ASCTDTEFRQMWQDFEWENKVTVNTSFTDLHEYLKHLLKSTNMKCLTPEKALSGQCGFMAANMYA 907
            |||||.||||||.:|||||||||||:.|||::||.|:|||||||||||||||||.|||||||:||
Zfish   833 ASCTDAEFRQMWAEFEWENKVTVNTNITDLNDYLLHILKSTNMKCLTPEKALSGICGFMAANLYA 897

  Fly   908 KSIFGENALANLSIEKPVD-DPDSKVTGHIRIRAKSQGMALSLGDKISSSQKQS 960
            :|||||:||||:|||||:. ..|:.|.||||||||||.|||||||||:.|||::
Zfish   898 RSIFGEDALANVSIEKPIHLGVDAPVNGHIRIRAKSQVMALSLGDKINLSQKRT 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaCOP	NP_523400.1	Adaptin_N	17..562	CDD:279882	378/547 (69%)
		Coatamer_beta_C	678..820	CDD:285019	101/145 (70%)
		Coatomer_b_Cpla	826..953	CDD:291472	100/127 (79%)
copb1	NP_001002013.1	Adaptin_N	26..550	CDD:279882	376/540 (70%)
		HEAT 1. /evidence=ECO:0000255	96..131		33/34 (97%)
		HEAT 2. /evidence=ECO:0000255	132..168		31/35 (89%)
		HEAT repeat	137..161	CDD:293787	21/23 (91%)
		HEAT repeat	173..211	CDD:293787	25/37 (68%)
		HEAT repeat	221..272	CDD:293787	43/50 (86%)
		HEAT 3. /evidence=ECO:0000255	240..276		27/35 (77%)
		HEAT 4. /evidence=ECO:0000255	277..314		28/36 (78%)
		HEAT repeat	280..307	CDD:293787	22/26 (85%)
		HEAT 5. /evidence=ECO:0000255	316..353		27/36 (75%)
		HEAT repeat	318..342	CDD:293787	17/23 (74%)
		HEAT 6. /evidence=ECO:0000255	396..433		30/36 (83%)
		Coatamer_beta_C	667..807	CDD:285019	101/142 (71%)
		Coatomer_b_Cpla	816..944	CDD:291472	100/127 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583900
Domainoid	1	1.000	711	1.000	Domainoid score	I115
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5664
Inparanoid	1	1.050	1247	1.000	Inparanoid score	I169
OMA	1	1.010	-	-		QHG54031
OrthoDB	1	1.010	-	-		D117726at33208
OrthoFinder	1	1.000	-	-		FOG0004277
OrthoInspector	1	1.000	-	-		oto39766
orthoMCL	1	0.900	-	-		OOG6_100064
Panther	1	1.100	-	-	LDO	PTHR10635
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R227
SonicParanoid	1	1.000	-	-		X3011
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800