DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment betaCOP and Ap4b1

DIOPT Version :9

Sequence 1:	NP_523400.1	Gene:	betaCOP / 32820	FlyBaseID:	FBgn0008635	Length:	964	Species:	Drosophila melanogaster
Sequence 2:	NP_001101179.1	Gene:	Ap4b1 / 310746	RGDID:	1310529	Length:	739	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	103/538 - (19%)
Similarity:	190/538 - (35%)	Gaps:	157/538 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 ETLKRVIKLLLNGE------RYPGLIMTIIRFVLPVQNHTIKKLLL--IFWEIVPKTSADGKLLQ 94
            :.:|.:.|.|.|..      ||..:|..:||       |..:.|.:  :|.|:| |.||...::|
  Rat     8 DVVKELKKALCNPHIQADRLRYRNVIQRVIR-------HMTQGLDMSDVFMEMV-KASATVDIVQ 64

  Fly    95 E-----------------MILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPELLEPLMPAIRACL 142
            :                 .:|..:...||...||..:||..||.:|.|:.|.:.|.:...:...|
  Rat    65 KKLVYLYMGTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPVVNGL 129

  Fly   143 DHRHSYVRRNAVLAIFTIYKNFDWLVPDGP---ELIASFLDTQQD----MSCKRNAFLMLLHADQ 200
            ..:.|||||.|||....::........||.   ||.:...|  ||    ::|.|:...:|   .|
  Rat   130 RDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRD--QDPIVVVNCLRSLEEIL---KQ 189

  Fly   201 ERAL-------NYLASCIDQVHTFGDILQLVIVELIYKVCHANPAERSRFIRCIYNLLNSSSNAV 258
            |..:       ::|.:.:.::..:|   |..::..:.:....:..|....:..:.:.|.|||..|
  Rat   190 EGGVVINKPIAHHLLNRMSKLDQWG---QAEVLNFLLRYQPRSEEELFDILNLLDSYLKSSSTGV 251

  Fly   259 RYESAGTLITLS------------------LAPTAIKA-----AASCYIELVVK----------- 289
            ...:....:.|:                  ||..:.::     ||.|::..|:.
  Rat   252 VMGATKLFLILAKKFPHVQTDVLVRVKGPLLAACSSESRELCFAALCHVRQVLHSLPGHFSSHYK 316

  Fly   290 ------ESDNNVKLIVLDRLVAMKEHEGMEKVMQDL---VMDVLRVLAAPDIEVRRKTLALALDL 345
                  ...:.:||..::.|..:...|.:::|:::|   ..||
  Rat   317 KFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDV---------------------- 359

  Fly   346 VYSRNIGEMVLVLKKEVAKTHNVEHEDTGKYRQLLVRTLHTCSIKFPDVAANVIPVLVEFLSDTN 410
              |.:..:..:.....:|||:..:                 |           :.:|.|.|....
  Rat   360 --SADFAQAAIFAIGNIAKTYTDQ-----------------C-----------VQILTELLGLRQ 394

  Fly   411 ELAAADVLIFIREAIQKFPALRALIIEHLIEAFPQIKSSKIHRAAVWILGEYVEGSQILEVIAVI 475
            |.....|:...|:.:...|.....:.:.|......|:.|:..:|.:|:||  |.|.:|.....|:
  Rat   395 EHITTVVVQTFRDLVWLCPQCTEAVCQALPGCEENIQDSEGKQALIWLLG--VHGEKIPNAPYVL 457

  Fly   476 QQTLGEV-----PMVEAE 488
            :..:..|     |.|:.|
  Rat   458 EDFVESVKSETFPAVKME 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaCOP	NP_523400.1	Adaptin_N	17..562	CDD:279882	103/538 (19%)
		Coatamer_beta_C	678..820	CDD:285019
		Coatomer_b_Cpla	826..953	CDD:291472
Ap4b1	NP_001101179.1	Adaptin_N	9..525	CDD:279882	103/537 (19%)
		HEAT repeat	86..113	CDD:293787	9/26 (35%)
		Cnd1	98..235	CDD:289487	34/144 (24%)
		HEAT repeat	120..150	CDD:293787	9/29 (31%)
		HEAT repeat	159..185	CDD:293787	7/27 (26%)
		HEAT repeat	198..222	CDD:293787	3/26 (12%)
		B2-adapt-app_C	620..732	CDD:198088
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810