DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment betaCOP and Ap3b2

DIOPT Version :9

Sequence 1:	NP_523400.1	Gene:	betaCOP / 32820	FlyBaseID:	FBgn0008635	Length:	964	Species:	Drosophila melanogaster
Sequence 2:	NP_001101002.2	Gene:	Ap3b2 / 308777	RGDID:	1308950	Length:	1082	Species:	Rattus norvegicus

Alignment Length:	1151	Identity:	202/1151 - (17%)
Similarity:	392/1151 - (34%)	Gaps:	351/1151 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LKRDLEKGDTNVKIETLKRVIKLLLNGERYPGLIMTIIRFVLPVQNHTIKKLLLIFWEIVPKTSA 88
            ||..|:....::|:|.:||::.::..|:....|...:::.| ..:|..:|||:.::.....:...
  Rat    42 LKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNV-ACKNIEVKKLVYVYLVRYAEEQQ 105

  Fly    89 DGKLLQEMILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPELLEPLMPAIRACLDHRHSYVRRNA 153
            |..||.     ...:::.|:.||:.:|.|.||.|..::.|.::..:|.||:........|||:.|
  Rat   106 DLALLS-----ISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTA 165

  Fly   154 VLAIFTIY-----------KNFDWLVPDGPELIASFLDTQQDMSCKRNAFLMLLHADQERALNYL 207
            ..||..:|           :..:.|:.|...|:|..:....:..|...  :.|:|.:..:..|.|
  Rat   166 AHAIPKLYSLDSDQKDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPER--IDLIHKNYRKLCNLL 228

  Fly   208 ASCIDQVHTFGDILQLVIVELIYKVCHANPAERSRFIRCIYN--LLNSSSNAVRY---------- 260
               || |..:|   |:||:.::.:..      |::|:....|  ||..:.....|
  Rat   229 ---ID-VEEWG---QVVIISMLTRYA------RTQFLSPTQNESLLEENPEKAFYGSEEDEAKGP 280

  Fly   261 --ESAGTL-----------------------ITLSLAPTAIKAAASCYIELVVK----------- 289
              |.|.|.                       :..|.:...:.|.|..|..|..|
  Rat   281 GSEEAATAALPARKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQLYFHLAPKAEVGVIAKALV 345

  Fly   290 ---ESDNNVKLIVLDRLVAMK-EHEGM-EKVMQDLVMDVLRVLAAPDIEVRRKTLALALDLVYSR 349
               .|.:.|:.:||..:..|. :..|| |..::...     :.:....:::...|.:..:|....
  Rat   346 RLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFY-----IRSTDPTQIKILKLEVLTNLANET 405

  Fly   350 NIGEMVLVLKKEVAKTHNVEHEDTGKYRQLLVRTLHTCSIKFPDVAANVIPVLVEFLSDTNELAA 414
            ||   ..||::......:::.:    :....::.:..|:.....|....:..||:.||:.:||..
  Rat   406 NI---PTVLREFQTYIRSMDKD----FVAATIQAIGRCATNIGRVRDTCLNGLVQLLSNRDELVV 463

  Fly   415 ADVLIFIREAIQKFPALRALIIEHLIEAFPQIKSSKIHRAAVWILGEYVEGSQILEVIAVIQQTL 479
            |:.::.|::.:|..||....||:||.:....|:......:.:|::|||.|
  Rat   464 AESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASILWLIGEYCE--------------- 513

  Fly   480 GEVPMVEAE-QRRLAGDQTEEQ---KQQQGSAGGNAAGSAAEGSGSGNASNKVTSDGTYATQSAY 540
             .||.:..: .|::|...|.|:   |.|       ....||:...:.:...|:      .||...
  Rat   514 -HVPKIAPDVLRKMAKSFTAEEDIVKLQ-------VINLAAKLYLTNSKQTKL------LTQYVL 564

  Fly   541 SLAP-----------------VAKAEK-----------------RPPLRQYLMDGDFFIGAALSA 571
            |||.                 :|.:|:                 .|.|.....|.|.|...:||.
  Rat   565 SLAKYDQNYDIRDRARFTRQLIAPSEQGGALSRHAKKLFLAPKPAPILESSFKDRDHFQLGSLSH 629

  Fly   572 TLTKLALRYAEL----------------------------------------------------- 583
            .|...|..|.||
  Rat   630 LLNAKATGYQELPDWPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSDSEGESGPTESADSE 694

  Fly   584 -ETEARAQNRLTTQVMLIMSSILHLGKSGFPSKPITNDDTDRIFVCLRTLSERTPEAISVFTLYC 647
             |:|:.:.::.:::           ..||..|....|:|.|
  Rat   695 PESESESGSKSSSE-----------SGSGESSSESDNEDDD------------------------ 724

  Fly   648 REALGKMLDAQHDEDQRMLKEKQKATAKVQPDDPVLFAQLSNGRDNQLGENVFESSLNQALAGSK 712
             |..|:..:::..|::   .||:|.|.|.:..:     ....|..::.|.:...||.::..:.|:
  Rat   725 -EEKGEGSESEQSEEE---GEKKKKTKKKKASE-----GHREGSSSEEGSDSSSSSESEVTSESE 780

  Fly   713 NAQL-----------SDVASPNSKLNKVTQLTGFSDP-VYAEAYVNVNQYDIVLDVLIVNQTNDT 765
            ..|:           |..::|.:|...:..|..|:.| |...:...|....:..|:..:..|:.:
  Rat   781 EEQVEPASWRKKTPPSSKSTPAAKEISLLDLEDFTSPSVQPVSPPMVVSTSLAADLEGLTLTDSS 845

  Fly   766 LQNCTLE-LATLGDLKLVER--------------------PH----------------------- 786
            |....|. ::::|..:|:.|                    ||
  Rat   846 LVPSLLSPVSSIGRQELLHRVAGEGLAVDYAFSRQPFSGDPHMVSLHIYFSNNSETPIKGLHVGT 910

  Fly   787 ---PVVLAPHDFCNIKANVKVSSTEN--GIIFGNIV----YETALNTNVVVLNTIHIDIMDYIIP 842
               |..::..:|..|::.....||..  ||.|.:..    ::....|....: :|...:.:.:.|
  Rat   911 PKLPAGISIQEFPEIESLAPGESTTTVMGINFCDSTQAANFQLCTQTRQFYV-SIQPPVGELMAP 974

  Fly   843 ASCTDTEFRQMWQDFEWENKVTVNTSFTDL----HEYLKHLLKSTNMKCLTPEKALSGQ--CGFM 901
            ...::.||::........|::|...:..|.    |..::.:..:.|:          |:  ||..
  Rat   975 VFMSENEFKKEQGKLTGMNEITEKLTLPDTCRSDHMVVQKVTATANL----------GRVPCGAS 1029

  Fly   902 AANMYAKSIFGENALANLSIEKPVDDPDSKVTGHIRIRAKSQGMAL 947
            ....:|.......:|..|::       |::.||..::...|:.|.:
  Rat  1030 DEYRFAGRTLTSGSLVLLTL-------DARGTGAAQLTVNSEKMVI 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaCOP	NP_523400.1	Adaptin_N	17..562	CDD:279882	125/639 (20%)
		Coatamer_beta_C	678..820	CDD:285019	31/206 (15%)
		Coatomer_b_Cpla	826..953	CDD:291472	20/128 (16%)
Ap3b2	NP_001101002.2	Adaptin_N	34..590	CDD:366724	121/609 (20%)
		HEAT repeat	111..139	CDD:293787	8/32 (25%)
		HEAT repeat	145..173	CDD:293787	9/27 (33%)
		HEAT repeat	182..208	CDD:293787	4/25 (16%)
		AP3B1_C	804..947	CDD:373301	23/142 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910