DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment betaCOP and sec26

DIOPT Version :9

Sequence 1:	NP_523400.1	Gene:	betaCOP / 32820	FlyBaseID:	FBgn0008635	Length:	964	Species:	Drosophila melanogaster
Sequence 2:	NP_595403.1	Gene:	sec26 / 2539798	PomBaseID:	SPBC146.14c	Length:	940	Species:	Schizosaccharomyces pombe

Alignment Length:	966	Identity:	392/966 - (40%)
Similarity:	612/966 - (63%)	Gaps:	53/966 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CYTIINSPDLEVTNEMQLKRDLEKGDTNVKIETLKRVIKLLLNGERYPGLIMTIIRFVLPVQNHT 71
            |:|::....||..:...||..||..:..|||..:|.::::::||:..|.::|.:||||:|.:|..
pombe     3 CWTLVQQDFLEAPSVDALKTSLESKNDYVKISAMKTILRVVINGDSLPSILMHVIRFVMPSRNKE 67

  Fly    72 IKKLLLIFWEIVPKTSADGKLLQEMILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPELLEPLMP 136
            :||||..:||:.||.:.||.:.|||||.|:::|.||||||||:||:||||||||||||||:||:|
pombe    68 LKKLLYYYWEVCPKYNNDGTMKQEMILACNSFRNDLQHPNEFIRGATLRFLCKLKEPELLDPLIP 132

  Fly   137 AIRACLDHRHSYVRRNAVLAIFTIYKNFDWLVPDGPELIASFLDTQQDMSCKRNAFLMLLHADQE 201
            .:|.||:|||:|||:||:||:|:||:..:.|:||...|...||..:.:.:|||||.::|...|.|
pombe   133 TVRQCLEHRHAYVRKNAILAVFSIYQVSNHLIPDAASLAEDFLAAESEGTCKRNALIVLFTIDPE 197

  Fly   202 RALNYLASCIDQVHTFGDILQLVIVELIYKV--CHANPAERSRFIRCIYNLLNSSSNAVRYESAG 264
            :|..:|.:..:|:.:......|||:|.|.||  ..|:..|:.||...:.:|..:::::|.:|:|.
pombe   198 KAKAWLLANFEQIPSLNASSLLVIIEFIRKVVLTKADGLEKLRFQSLLVSLTATNNSSVVFEAAT 262

  Fly   265 TLITLSLAPTAIKAAASCYIELVVKESDNNVKLIVLDRLVAMKEHEGMEKVMQDLVMDVLRVLAA 329
            ::|.:.....::|.|||..:.|..:|:|||.|||:|||:..:...:  :.:::||:.||:..|::
pombe   263 SVINVFPDAESLKLAASRLLALADREADNNAKLIMLDRISQLAARD--KSILEDLITDVIPFLSS 325

  Fly   330 PDIEVRRKTLALALDLVYSRNIGEMVLVLKKEVAKTHNVEHEDTGKYRQLLVRTLHTCSIKFPDV 394
            .|.:|..|.:::.:.||.|||:.:::...:||:.|::....:|.|: |:.|.:.:|:|:|.||..
pombe   326 SDFDVCEKAISIIMGLVSSRNVEDILNHFQKELTKSNGETEKDDGR-RRALTKAIHSCAINFPHT 389

  Fly   395 AANVIPVLVEFLSDTNELAAADVLIFIREAIQKFPALRALIIEHLIEAFPQIKSSKIHRAAVWIL 459
            ||..|..|:..:||....:|:.||.||:|.::|||.||:..|..|:.:..::::.||.|..:||.
pombe   390 AATAIQYLLSHISDFQSKSASSVLSFIKEVMEKFPDLRSSNITKLLLSLKELRAGKIFRGVIWIA 454

  Fly   460 GEYVEGSQILEVI-AVIQQTLGEVPMVEAEQRRL--AGDQTEEQKQQQGSAGGNAAGSAAEGSGS 521
            |||......:.|. ..|:.:|||||::.:|::.|  ..:..|:.             ...:.|..
pombe   455 GEYCLTEDDIRVAWKSIRASLGEVPILASEEQLLKDVSNVPEDD-------------LLIDISAP 506

  Fly   522 GNASNKVTSDGTYATQSAYSLAPVA-------KAEKRPPLRQYLMDGDFFIGAALSATLTKLALR 579
            .:.|.||..||||||:||.:...::       ||.|:||||..::.||:::.|.|::.||||.:|
pombe   507 ASTSRKVLPDGTYATESAVTSEALSAARLEAVKASKKPPLRTQILSGDYYLAAVLASALTKLVMR 571

  Fly   580 YAELETEARAQNRLTTQVMLIMSSILHLGKSGFPSKPITNDDTDRIFVCLRTL--SERTPEAISV 642
            :|.|..:....|.|..:..|||:||:.:|:|.|....|.:|..:||..|:|.:  .|..||..:|
pombe   572 FARLSFDKERLNALKAEACLIMTSIIRVGQSKFVKYTIDDDSVERIMNCIRAIYSFEELPEFQTV 636

  Fly   643 FTLYCREALGKMLDAQHDEDQRMLKEKQKATAKVQPDDPVLFAQLSNGRDNQ--LGENV---FES 702
            |....|:|...:: ||.|      |.:::|...|...|.|...:|.|.|..|  :.|..   |||
pombe   637 FLDDMRKAFSSLV-AQSD------KRQKEADLLVNGSDAVQADELLNIRQFQRVIEEKQDLNFES 694

  Fly   703 SLNQALAGSKNAQLSDVASPNSKLNKVTQLTGFSDPVYAEAYVNVNQYDIVLDVLIVNQTNDTLQ 767
            .:.||.  :....:.|:|   |||:.:.||.||:||||.||||.:.|:||:||:|:||:|:.|||
pombe   695 DIIQAT--NDGMVVEDLA---SKLDHIVQLAGFTDPVYCEAYVKIQQFDIILDILLVNRTDTTLQ 754

  Fly   768 NCTLELATLGDLKLVERPHPVVLAPHDFCNIKANVKVSSTENGIIFGNIVY--ETALNTNVVVLN 830
            |.:::||||||||:||||.|:.|.||.|.:::|.|||||||:.:|||||||  :.:....:||||
pombe   755 NLSVDLATLGDLKVVERPPPMNLGPHAFKSVQATVKVSSTESAVIFGNIVYGGKASDEDKIVVLN 819

  Fly   831 TIHIDIMDYIIPASCTDTEFRQMWQDFEWENKVTVNTS-FTDLHEYLKHLLKSTNMKCLTPEKAL 894
            .|.::|:|||.||...:::||.||.:|||||||.:::: ...|:::|..::|.|||.||||:.:|
pombe   820 GIPVNIIDYIKPAFIPESQFRSMWTEFEWENKVDISSNEDISLYDFLHKIMKKTNMNCLTPDASL 884

  Fly   895 SGQCGFMAANMYAKSIFGENALANLSIEKPVDDPDSKVTGHIRIRAKSQGMALSLG 950
            .|.|||::||:||.|||||:||.:||:||.|..|   ::||:|||:|:||:|||||
pombe   885 RGDCGFLSANLYACSIFGEDALMSLSVEKSVSGP---ISGHVRIRSKTQGIALSLG 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaCOP	NP_523400.1	Adaptin_N	17..562	CDD:279882	208/556 (37%)
		Coatamer_beta_C	678..820	CDD:285019	74/148 (50%)
		Coatomer_b_Cpla	826..953	CDD:291472	67/126 (53%)
sec26	NP_595403.1	COG5096	1..923	CDD:227427	380/950 (40%)
		Coatamer_beta_C	671..807	CDD:285019	72/140 (51%)
		Coatomer_b_Cpla	816..937	CDD:291472	65/123 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	366	1.000	Domainoid score	I144
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5664
Inparanoid	1	1.050	707	1.000	Inparanoid score	I99
OMA	1	1.010	-	-		QHG54031
OrthoFinder	1	1.000	-	-		FOG0004277
OrthoInspector	1	1.000	-	-		oto101043
orthoMCL	1	0.900	-	-		OOG6_100064
Panther	1	1.100	-	-	LDO	PTHR10635
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R227
SonicParanoid	1	1.000	-	-		X3011
TreeFam	1	0.960	-	-
	14	13.860