Protein Alignment betaCOP and apb-1

DIOPT Version :9

• Sequence 1: NP_523400.1
• Gene: betaCOP / 32820
• FlyBaseID: FBgn0008635
• Length: 964
• Species: Drosophila melanogaster
• Sequence 2: NP_001022937.1
• Gene: apb-1 / 175376
• WormBaseID: WBGene00000160
• Length: 955
• Species: Caenorhabditis elegans
• Alignment Length: 1036
• Identity: 200/1036 - (19%)
• Similarity: 364/1036 - (35%)
• Gaps: 243/1036 - (23%)

  Fly    23 QLKRDLEKGDTNVKIETLKRVIKLLLNGERYPGLIMTIIRFVLPVQNHTIKKLLLIFWEIVPKTS 87
            :||.:|.......|.|.:|:||..:..|:....|...::. .:...|..:|||:.::.....|:.
 Worm    17 ELKNELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVN-CMQTDNVELKKLVYLYLMNYAKSQ 80

  Fly    88 ADGKLLQEMILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPELLEPLMPAIRACLDHRHSYVRRN 152
            .|     ..|:..:.:.||.:.||..:|...:|.:..::..::.|.|...:|.|:.....|||:.
 Worm    81 PD-----LAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVEKITEYLCDPLRRCMKDEDPYVRKT 140

  Fly   153 AVLAIFTIYKNFDWLVPDG--PELIASFLDTQQDMSCKRNAFLMLLHADQERA--------LNYL 207
            |.:.:..::.....||.:.  .||:...|.....| ...||...|...::::.        :|.|
 Worm   141 AAVCVAKLHDMNPALVKEQGFVELLNDLLSDANPM-VVANAVAALTEMNEQQTVIEVNSQMVNKL 204

  Fly   208 ASCIDQVHTFGDIL----------------QLVIVELIYKVCHANPAERSRFIRCIYNLLN---S 253
            .:.:::...:|.:.                |.:...:..::.|||.|.....::.:..|::   :
 Worm   205 LTALNECTEWGQVFILDALAGYTPRDERETQNICERISPRLAHANAAVVLSTVKVLMKLIDMMPA 269

  Fly   254 SSNAVRYESAGTLITLSLAP---TAIKAAASC-YIELVVKESDNNVKLIVLDRLVAMKEHEGMEK 314
            .|:.:      |.:|..|||   |.:.|.... |:.|      .|:.|||..|...:|:.
 Worm   270 DSDFI------TQLTKKLAPPMVTLLSAEPEIQYVAL------RNINLIVQKRPDILKQE----- 317

  Fly   315 VMQDLVMDVLRVLAAPDIEVRRKTLALALDLVYSRNIGEMVLVLKKEVAKTHNVEHEDTGKYRQL 379
                  |.|..|.....|.|:.:.|.:.:.|....||.:::..| ||.|...:|:      :.:.
 Worm   318 ------MKVFFVKYNDPIYVKMEKLDIMIRLAQQNNIAQVLSEL-KEYATEVDVD------FVRK 369

  Fly   380 LVRTLHTCSIKFPDVAANVIPVLVEFLSDTNELAAADVLIFIREAIQKFPALRALIIEHLIEAFP 444
            .||.:..|:||....:...:..|:|.:.........:.::.|::..:|:|.....||..|.|...
 Worm   370 SVRAIGRCAIKVEASSERCVQTLLELIQTKVNYVVQEAVVVIKDIFRKYPNRYESIISALCENLD 434

  Fly   445 QIKSSKIHRAAVWILGEYVE----GSQILE-----------------VIAVIQQTLGEVPMVEAE 488
            .:...:...:.:||:|||.|    ..::||                 :.||::..|....:.:|.
 Worm   435 TLDEPEARASMIWIIGEYAERIDNADELLESFVEGFHDENTQVQLQLLTAVVKLFLKRPGVAQAL 499

  Fly   489 QRRLAGDQTEEQKQQQGSAGG------NAAGSAAEGSGSGNASNKVTSDGTYATQSAYSLAP--- 544
            .:|:....|::.........|      .:|..||       |.|.|.::....::....|.|
 Worm   500 VQRVLSLATQDSDNPDLRDRGFIYWRLLSADPAA-------AKNVVLTEKPLISEETDLLEPSLL 557

  Fly   545 ---------VAKAEKRPPLRQYLMDGDFFIGAALSATLTKLALRYAELETEARAQNRLTTQVMLI 600
                     :|....:||        ..||..|      |..||.......|:..:.|     |.
 Worm   558 EQLVCHIGTLASVYHKPP--------SAFIDPA------KAPLRQINPIPAAKFGSSL-----LD 603

  Fly   601 MSSILHLGKSGFPSKPITNDDTDRIFVCLRTLSERTPEAISVFTLYCREALGKMLDAQHDEDQRM 665
            .||..:..::|..:.|......|::...|.:|....| |.|..|    .|.|..:..
 Worm   604 TSSTPNAARNGSAAAPTVIPSQDQVIADLLSLDLNAP-AASANT----GAFGGAMSG-------- 655

  Fly   666 LKEKQKATAKVQPDDPVLFAQLSNGRD-------NQLGENVFESSLNQALAGSKNAQLSDVASPN 723
                  .|:....||     .|..|.|       |....|.|:     .|.|...|  :..|.|:
 Worm   656 ------TTSMGGLDD-----LLGLGGDPMPAAPTNSASYNPFD-----GLGGLGGA--APAAPPS 702

  Fly   724 SKLNKVTQLT---------GFSDPVY-AEAYVNVNQY--------------DIVLDVLIVNQTND 764
            .:...:..|.         |.|...| .|.:::.::.              .|.:::.|.|:...
 Worm   703 QQPASIGGLAEIFGSGGFGGSSGITYPKELWLDASKAMGMQVEGTFVRRGGKIFMEMTITNRAMQ 767

  Fly   765 TLQNCTLEL--ATLGDLKLVERPHPVVLAPHDFCNIKANVKVSSTENGIIFGNIVYETALNTNVV 827
            .:....|:.  .:.| |..||:.:|..:.|    |...|..::....|.:   .|.....|..|.
 Worm   768 AISGFALQFNKNSFG-LIPVEQVNPAPILP----NQSQNYTIACDTTGAV---QVTTPLTNLQVA 824

  Fly   828 VLNTIHIDIMDYIIP--------ASCTDTEFRQMW--------QDFEWEN-----------KVTV 865
            :.|.|:.......:|        ......||.:.|        |.|..:|           |:..
 Worm   825 IKNDINAFYFATTVPLLAYFREDGQMEKREFLEEWKSIPEQNEQQFTLQNTHNMNADAICTKLQQ 889

  Fly   866 NTSFT------DLHEYLKHLLKSTNMKCLTPEKALSGQCGFMAANMYAKSIFGENALANLS 920
            |...|      |..:.|.|.:|.||...:..|..::.|...:..::.:|::.   |:||::
 Worm   890 NNIHTVARRQVDNQQLLYHSVKYTNNLNVLSELKVNSQTTSITLSLKSKNLM---AIANIN 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
betaCOP	NP_523400.1	Adaptin_N	17..562	CDD:279882	119/610 (20%)
		Coatamer_beta_C	678..820	CDD:285019	32/174 (18%)
		Coatomer_b_Cpla	826..953	CDD:291472	25/128 (20%)
apb-1	NP_001022937.1	Adaptin_N	11..531	CDD:279882	109/550 (20%)
		HEAT repeat	51..75	CDD:293787	4/24 (17%)
		HEAT repeat	87..114	CDD:293787	6/26 (23%)
		Cnd1	99..265	CDD:289487	29/166 (17%)
		HEAT repeat	121..151	CDD:293787	7/29 (24%)
		HEAT repeat	160..186	CDD:293787	7/26 (27%)
		HEAT repeat	197..224	CDD:293787	3/26 (12%)
		HEAT repeat	389..413	CDD:293787	3/23 (13%)
		HEAT repeat	425..454	CDD:293787	9/28 (32%)
		HEAT repeat	461..491	CDD:293787	4/29 (14%)
		HEAT repeat	502..538	CDD:293787	8/42 (19%)
		Alpha_adaptinC2	736..834	CDD:197886	18/105 (17%)
		B2-adapt-app_C	844..955	CDD:198088	21/107 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910