DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment betaCOP and copb-1

DIOPT Version :9

Sequence 1:	NP_523400.1	Gene:	betaCOP / 32820	FlyBaseID:	FBgn0008635	Length:	964	Species:	Drosophila melanogaster
Sequence 2:	NP_494441.1	Gene:	copb-1 / 173656	WormBaseID:	WBGene00021292	Length:	971	Species:	Caenorhabditis elegans

Alignment Length:	983	Identity:	565/983 - (57%)
Similarity:	717/983 - (72%)	Gaps:	53/983 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TSQVPCYTIINSP-DLEVTNEMQLKRDLEKGDTNVKIETLKRVIKLLLNGER-YPGLIMTIIRFV 64
            :.:.||||:|:.| |.|:.:|.|||...|||....:||.||::|.::||||: ...::|.:|||.
Worm     3 SGEQPCYTLIHVPSDAELPSEAQLKEKFEKGGDKERIEALKKLIYMILNGEKTSQSMLMYVIRFC 67

  Fly    65 LPVQNHTIKKLLLIFWEIVPKTSADGKLLQEMILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPE 129
            ||...||:||:||||||.||||.::||||.|||||||||||||||||||:|||||||||||:|||
Worm    68 LPSNEHTLKKVLLIFWECVPKTDSNGKLLHEMILVCDAYRKDLQHPNEFVRGSTLRFLCKLREPE 132

  Fly   130 LLEPLMPAIRACLDHRHSYVRRNAVLAIFTIYKNFDWLVPDGPELIASFLDTQQDMSCKRNAFLM 194
            |||||||||||||:|||||||||||.|||||||||::|:||.|||:..:|:.:||.|||||||:|
Worm   133 LLEPLMPAIRACLEHRHSYVRRNAVCAIFTIYKNFEFLIPDAPELVTEYLEQEQDASCKRNAFMM 197

  Fly   195 LLHADQERALNYLASCIDQVHTFGDILQLVIVELIYKVCHANPAERSRFIRCIYNLLNSSSNAVR 259
            |||.||.|||:||:.|||||.:||||||||||||||||||.||.|.||||||:||||.|||.|||
Worm   198 LLHVDQARALDYLSGCIDQVGSFGDILQLVIVELIYKVCHNNPNEASRFIRCVYNLLQSSSPAVR 262

  Fly   260 YESAGTLITLSLAPTAIKAAASCYIELVVKESDNNVKLIVLDRLVAMKEHEGMEKVMQDLVMDVL 324
            ||:||||:|||..|.|:|||||.||:|:||||||||||||||||||::.....||::|.||||:|
Worm   263 YEAAGTLVTLSNVPAAVKAAASAYIDLIVKESDNNVKLIVLDRLVALRGSSSNEKILQGLVMDIL 327

  Fly   325 RVLAAPDIEVRRKTLALALDLVYSRNIGEMVLVLKKEVAKTHNVEHEDTGKYRQLLVRTLHTCSI 389
            |||::|.:|||:|||:||||||.|||:.:||:.||||:.||....:::.|||||.||:|||..:|
Worm   328 RVLSSPGLEVRKKTLSLALDLVSSRNVEDMVMFLKKEINKTATESNDENGKYRQELVKTLHAATI 392

  Fly   390 KFPDVAANVIPVLVEFLSDTNELAAADVLIFIREAIQKFPALRALIIEHLIEAFPQIKSSKIHRA 454
            ||||||:.::|||:||||||||.|::.||.|:|||:.|.|.|:..|:..|.|..|.|:|..|..:
Worm   393 KFPDVASTIVPVLMEFLSDTNEKASSYVLQFVREAVHKLPNLKNAILGALREGIPFIQSPTIFMS 457

  Fly   455 AVWILGEYVEGSQILEVIAVIQQTLGEVPMVEAEQRRLAG-------DQTEEQKQQQGSAGGNAA 512
            |:|||..|.|....|:|:.:::.:|||:|:|::|   |:|       :|..||:|:|
Worm   458 ALWILATYCEADGALDVLKLVKNSLGELPLVDSE---LSGQEEQKPEEQQPEQQQKQ-------- 511

  Fly   513 GSAAEGSGSGNASNKVTSDGTYATQSAY-SLAPVAKAEKRPPLRQYLMDGDFFIGAALSATLTKL 576
                        ..|||:|||||||:|. |....:|..::||||::|:||:||:||:|:..||||
Worm   512 ------------KPKVTADGTYATQTALSSTVTTSKKNEKPPLRRFLLDGEFFLGASLATVLTKL 564

  Fly   577 ALRYAELETEARAQ-NRLTTQVMLIMSSILHLGKSG--FPSKPITNDDTDRIFVCLRTLSERTPE 638
            |.::.||...|..: ||...:.|||:|||:||.|||  ...:.:..||.||:...::.|::..|.
Worm   565 AQQFTELNGAASERANRFRAECMLILSSIIHLAKSGLCIVHQQVNEDDLDRMGATIKILAQGIPG 629

  Fly   639 AISVFTLYCREALGKMLDAQHDEDQRMLKEKQKATAK--------VQPDDPVLFAQLSNGRDNQL 695
            ....:...|:::|..||.|:......:..||..:|..        |:.|..:.|.||| .|.||.
Worm   630 LDEQYGDDCKKSLELMLGAKSISRLDVTTEKMASTTAAGYRSKDFVEIDKTINFTQLS-ARSNQQ 693

  Fly   696 GENVFESSLNQALAGSKNAQLSDVASPNSKLNKVTQLTGFSDPVYAEAYVNVNQYDIVLDVLIVN 760
            |||:|:.||:|||..:..||..|.:|  |||.||.||.|||||:|||||||||||||||||||||
Worm   694 GENLFDLSLSQALGTAPKAQKFDFSS--SKLGKVIQLAGFSDPIYAEAYVNVNQYDIVLDVLIVN 756

  Fly   761 QTNDTLQNCTLELATLGDLKLVERPHPVVLAPHDFCNIKANVKVSSTENGIIFGNIVYETALNT- 824
            ||:|||||.:|||||:||||||::|.||.|||:||.||||.|||:|||||:||..|.|:...:|
Worm   757 QTSDTLQNVSLELATVGDLKLVDKPTPVTLAPNDFSNIKATVKVASTENGVIFSTISYDVTGSTS 821

  Fly   825 --NVVVLNTIHIDIMDYIIPASCTDTEFRQMWQDFEWENKVTVNTSFTDLHEYLKHLLKSTNMKC 887
              |.|.|..|.|||||||:|.:.||||||.||.||||||||.|.|...||.::|.||..|||||.
Worm   822 DRNCVYLQDIKIDIMDYIVPGNVTDTEFRTMWSDFEWENKVNVMTPIRDLRDFLNHLSTSTNMKV 886

  Fly   888 LTPEKALSGQCGFMAANMYAKSIFGENALANLSIEK--PVDDPDSKVTGHIRIRAKSQGMALSLG 950
            ||.:.|:.|.|||:|||:.|.|||||:||||:|:||  |:|| .|.:.||||||||||||.|:||
Worm   887 LTGDAAIEGDCGFLAANLCAHSIFGEDALANVSVEKALPMDD-SSPIVGHIRIRAKSQGMCLTLG 950

  Fly   951 DKISSSQK 958
            ||:||:.:
Worm   951 DKLSSAMR 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaCOP	NP_523400.1	Adaptin_N	17..562	CDD:279882	333/553 (60%)
		Coatamer_beta_C	678..820	CDD:285019	96/141 (68%)
		Coatomer_b_Cpla	826..953	CDD:291472	82/128 (64%)
copb-1	NP_494441.1	COG5096	31..935	CDD:227427	534/930 (57%)
		HEAT repeat	138..162	CDD:293787	21/23 (91%)
		HEAT repeat	174..222	CDD:293787	30/47 (64%)
		HEAT repeat	245..275	CDD:293787	24/29 (83%)
		HEAT repeat	284..308	CDD:293787	20/23 (87%)
		HEAT repeat	319..343	CDD:293787	15/23 (65%)
		Coatamer_beta_C	677..816	CDD:285019	96/141 (68%)
		Coatomer_b_Cpla	825..953	CDD:291472	82/128 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161141
Domainoid	1	1.000	605	1.000	Domainoid score	I93
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5664
Inparanoid	1	1.050	1058	1.000	Inparanoid score	I130
Isobase	1	0.950	-	0	Normalized mean entropy	S39
OMA	1	1.010	-	-		QHG54031
OrthoDB	1	1.010	-	-		D117726at33208
OrthoFinder	1	1.000	-	-		FOG0004277
OrthoInspector	1	1.000	-	-		oto19422
orthoMCL	1	0.900	-	-		OOG6_100064
Panther	1	1.100	-	-	LDO	PTHR10635
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R227
SonicParanoid	1	1.000	-	-		X3011
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750