Protein Alignment betaCOP and AP2B1

DIOPT Version :9

• Sequence 1: NP_523400.1
• Gene: betaCOP / 32820
• FlyBaseID: FBgn0008635
• Length: 964
• Species: Drosophila melanogaster
• Sequence 2: XP_011522750.1
• Gene: AP2B1 / 163
• HGNCID: 563
• Length: 983
• Species: Homo sapiens
• Alignment Length: 1074
• Identity: 206/1074 - (19%)
• Similarity: 356/1074 - (33%)
• Gaps: 315/1074 - (29%)

  Fly    19 TNE----MQLKRDLEKGDTNVKIETLKRVIKLLLNGERYPGLIMTIIRFVLPVQNHTIKKLLLIF 79
            ||:    .:||.:|.......:.|.:|:||..:..|:....|...::. .:...|..:|||:.::
Human     9 TNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVN-CMQTDNLELKKLVYLY 72

  Fly    80 WEIVPKTSADGKLLQEMILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPELLEPLMPAIRACLDH 144
            .....|:..|     ..|:..:::.||.:.||..:|...:|.:..::..::.|.|...:|.||..
Human    73 LMNYAKSQPD-----MAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKD 132

  Fly   145 RHSYVRRNAVLAIFTIYKNFDWLVPDGPELIASFLDTQQDMSCKRNAFLMLLHADQERALNYLAS 209
            ...|||:.|.:.:..::.....:|.|     ..|||:.:|:....|..::   |:...||    |
Human   133 EDPYVRKTAAVCVAKLHDINAQMVED-----QGFLDSLRDLIADSNPMVV---ANAVAAL----S 185

  Fly   210 CIDQVHTFGDILQLVIVELIYKVCHANPAERSRFIRCIYN--------LLNSSSN---------- 256
            .|.:.|...::|.|            ||...::.:..:..        :|:..||
Human   186 EISESHPNSNLLDL------------NPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQ 238

  Fly   257 ------AVRYESAGTLITLSLAPTAIKAAASCYIELVVKESD----------------------- 292
                  ..|...|.:.:.||.....:|     ::||:.|:||
Human   239 SICERVTPRLSHANSAVVLSAVKVLMK-----FLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEV 298

  Fly   293 -----NNVKLIVLDRLVAMKEHEGMEKVMQDLVMDVLRVLAAPDIEVRRKTLALALDLVYSRNIG 352
                 .|:.|||..|...:|:.           :.|..|.....|.|:.:.|.:.:.|....||.
Human   299 QYVALRNINLIVQKRPEILKQE-----------IKVFFVKYNDPIYVKLEKLDIMIRLASQANIA 352

  Fly   353 EMVLVLKKEVAKTHNVEHEDTGKYRQLLVRTLHTCSIKFPDVAANVIPVLVEFLSDTNELAAADV 417
            : ||...||.|...:|:      :.:..||.:..|:||....|...:..|::.:.........:.
Human   353 Q-VLAELKEYATEVDVD------FVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEA 410

  Fly   418 LIFIREAIQKFPALRALIIEHLIEAFPQIKSSKIHRAAVWILGEYVE----GSQILEVI------ 472
            ::.||:..:|:|.....||..|.|....:.......|.:||:|||.|    ..::||..
Human   411 IVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHD 475

  Fly   473 --AVIQQTLGEVPMVEAEQRRLAGDQTEEQKQQQGSAGGNAAGSAAEGSGSGNASNKVTSDGTYA 535
              ..:|.|| ...:|:...::  ..:|:|..||..|.            .:.::.|....|..|.
Human   476 ESTQVQLTL-LTAIVKLFLKK--PSETQELVQQVLSL------------ATQDSDNPDLRDRGYI 525

  Fly   536 TQSAYSLAPVAKAE----KRPPLRQYLMDGDFFIGAALSATLTKLALRYAELETEARAQNRLTTQ 596
            .....|..||...|    ::|.:.:                           ||:......|...
Human   526 YWRLLSTDPVTAKEVVLSEKPLISE---------------------------ETDLIEPTLLDEL 563

  Fly   597 VMLI--MSSILHL-------GKSGFPSK--PITNDDTDR----IFVCLRTLSERTPEAI------ 640
            :..|  ::|:.|.       |..|...|  ||.:..||.    :.....|..|: |:.|
Human   564 ICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGTTTATNLEQ-PQVIPSQGDL 627

  Fly   641 ------------------SVFTLYCREALGKMLDAQHDED------------QRMLKEKQKATAK 675
                              |...:...:.||..||:....|            |..:.....||..
Human   628 LGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLLGSDLGGGIGGSPAVGQSFIPSSVPATFA 692

  Fly   676 VQPDDPVLFA------QLSNGRDNQLGENVFESSLNQALAGSKNAQLS--------DVASPNSKL 726
            ..|...|:.:      :||.|.....|..|...::......:|..::|        .:....:..
Human   693 PSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFT 757

  Fly   727 NKVTQ-LTGFSDPVYAEAYVNVNQYDIVLDV-------LIVNQTNDTLQNCTLELATLGDLKLVE 783
            ||..| :|.|:      ...|.|.:.::...       |:.||:.|.    :|.|.|||.:..:|
Human   758 NKALQHMTDFA------IQFNKNSFGVIPSTPLAIHTPLMPNQSIDV----SLPLNTLGPVMKME 812

  Fly   784 RPHPVVLAPHDFCNIKAN----VKVSSTENGIIFGNIVYETALNTNVVVLNTIHIDIMDYIIPAS 844
                    |.:...:|:.    :..|..||..|....:........|.|.|.|.:.....:||.:
Human   813 --------PLNNLQVKSKENNWMDTSGRENANIMEKGIQAPFKVRKVAVKNNIDVFYFSCLIPLN 869

  Fly   845 CTDTE--------FRQMWQDFEWENKV------------TVNTSFTDLHEY------------LK 877
            ....|        |...|:|...||::            ||::...:.:.|            |.
Human   870 VLFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLY 934

  Fly   878 HLLKSTN--------------------MKCLTPE 891
            ..||.||                    :||..||
Human   935 QSLKLTNGIWILAELRIQPGNPNYTLSLKCRAPE 968

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
betaCOP	NP_523400.1	Adaptin_N	17..562	CDD:279882	124/614 (20%)
		Coatamer_beta_C	678..820	CDD:285019	32/167 (19%)
		Coatomer_b_Cpla	826..953	CDD:291472	24/118 (20%)
AP2B1	XP_011522750.1	Adaptin_N	11..534	CDD:307641	118/590 (20%)
		HEAT repeat	51..75	CDD:293787	4/24 (17%)
		HEAT repeat	87..114	CDD:293787	6/26 (23%)
		HEAT repeat	121..151	CDD:293787	8/29 (28%)
		HEAT repeat	160..186	CDD:293787	8/32 (25%)
		HEAT repeat	197..228	CDD:293787	5/42 (12%)
		HEAT repeat	392..416	CDD:293787	2/23 (9%)
		HEAT repeat	428..457	CDD:293787	10/28 (36%)
		HEAT repeat	464..494	CDD:293787	6/30 (20%)
		HEAT repeat	505..541	CDD:293787	9/47 (19%)
		Alpha_adaptinC2	731..825	CDD:197886	21/111 (19%)
		B2-adapt-app_C	872..982	CDD:198088	18/97 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810