DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment betaCOP and AP1B1

DIOPT Version :9

Sequence 1:	NP_523400.1	Gene:	betaCOP / 32820	FlyBaseID:	FBgn0008635	Length:	964	Species:	Drosophila melanogaster
Sequence 2:	NP_001118.3	Gene:	AP1B1 / 162	HGNCID:	554	Length:	949	Species:	Homo sapiens

Alignment Length:	975	Identity:	189/975 - (19%)
Similarity:	330/975 - (33%)	Gaps:	265/975 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QLKRDLEKGDTNVKIETLKRVIKLLLNGERYPGLIMTIIRFVLPVQNHTIKKLLLIFWEIVPKTS 87
            :||.:|.......|.|.:|:||..:..|:....|...::. .:...|..:|||:.::.....|:.
Human    17 ELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVN-CMQTDNLELKKLVYLYLMNYAKSQ 80

  Fly    88 ADGKLLQEMILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPELLEPLMPAIRACLDHRHSYVRRN 152
            .|     ..|:..:.:.||.:.||..:|...:|.:..::..::.|.|...:|.||.....|||:.
Human    81 PD-----MAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKT 140

  Fly   153 AVLAIFTIYKNFDWLVPDGPELIASFLDTQQDMSCKRNAFLM------------------LLHAD 199
            |.:.:..::.....||.|     ..||||.:|:....|..::                  ||..:
Human   141 AAVCVAKLHDINAQLVED-----QGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLN 200

  Fly   200 QERALNYLASCIDQVHTFGDIL----------------QLVIVELIYKVCHANPAERSRFIRCIY 248
            .: ::|.|.:.:::...:|.|.                |.:...:..::.|||.|.....::.:.
Human   201 PQ-SINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLM 264

  Fly   249 NLLNSSSNAVRYESAGTLITLSLAP---TAIKAAASC-YIELVVKESDNNVKLIVLDRLVAMKEH 309
            ..:...|..:.|  .|||:. .|||   |.:.|.... |:.|      .|:.|||..|...:| |
Human   265 KFMEMLSKDLDY--YGTLLK-KLAPPLVTLLSAEPELQYVAL------RNINLIVQKRPEILK-H 319

  Fly   310 EGMEKVMQDLVMDVLRVLAAPDIEVRRKTLALALDLVYSRNIGEMVLVLKKEVAKTHNVEHEDTG 374
            |          |.|..|.....|.|:.:.|.:.:.|....||.: ||...||.|...:|:
Human   320 E----------MKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQ-VLAELKEYATEVDVD----- 368

  Fly   375 KYRQLLVRTLHTCSIKFPDVAANVIPVLVEFLSDTNELAAADVLIFIREAIQKFPALRALIIEHL 439
             :.:..||.:..|:||....|...:..|::.:.........:.::.|::..:|:|.....:|..|
Human   369 -FVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATL 432

  Fly   440 IEAFPQIKSSKIHRAAVWILGEYVE----GSQILEVIAV---IQQTLGEVPMVEAEQRRLAGDQT 497
            .|....:...:...|.:||:|||.|    ..::||....   .:.|..::.::.|..:......|
Human   433 CENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPT 497

  Fly   498 EEQKQQQGSAGGNAAGSAAEGSGSGNASNKVTSDGTYATQSAYSLAPVAKAEKRPPLRQYLMDGD 562
            |.|:..|     .....|.:.|     .|....|..|......|..|||..|
Human   498 ETQELVQ-----QVLSLATQDS-----DNPDLRDRGYIYWRLLSTDPVAAKE------------- 539

  Fly   563 FFIGAALSATLTKLALRYAELETEARAQNRLTTQVMLIMSSILHLGKSGFPSKPITNDDTDRIFV 627
                                              |:|             ..||:.:::||.|
Human   540 ----------------------------------VVL-------------AEKPLISEETDLI-- 555

  Fly   628 CLRTLSERTPEAISVFTLYCREALGKMLDAQHDEDQRMLKEKQKATAKVQPDDPVLFAQLSNGRD 692
                    .|..:.....|    :|.:....|                 :|  |..|.:   |
Human   556 --------EPTLLDELICY----IGTLASVYH-----------------KP--PSAFVE---G-- 584

  Fly   693 NQLGENVFESSLNQALAGSKNAQLSDVA---SPNSKLNKVTQLTG--------------FSDPVY 740
               |..|...||....|.|::|:..:.|   :|..:...|....|              .|.|..
Human   585 ---GRGVVHKSLPPRTASSESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPL 646

  Fly   741 AEAYVNVNQYDIV---LDVLIVNQTNDTLQNCTLELATLGDLKLVERPHPVVLAPHDFCNIKANV 802
            |.:.|.:...|::   ||.|:.::...           :|....|..|...|.|     |:.|.:
Human   647 ATSSVQMGAVDLLGGGLDSLMGDEPEG-----------IGGTNFVAPPTAAVPA-----NLGAPI 695

  Fly   803 KVSSTENGIIFGNIVYETALNTNVVVLNTIHIDIMDYIIPASCTDTEFRQMWQDFEWENKVTVNT 867
            ....::   :|.       |.:.|..|:.      .|:.|        :.:|........:.::.
Human   696 GSGLSD---LFD-------LTSGVGTLSG------SYVAP--------KAVWLPAMKAKGLEISG 736

  Fly   868 SFTDLHEYLKHLLKSTNMKCLTPEKALSGQCGFMAANMYAKSIFGENALANLSIEKPVDDPDSKV 932
            :||       ..:.|.:|......|||.....|  |..:.::.||....|.|.:..|: .|:..|
Human   737 TFT-------RQVGSISMDLQLTNKALQVMTDF--AIQFNRNSFGLAPAAPLQVHAPL-SPNQTV 791

Fly 933 932
Human 792 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
betaCOP	NP_523400.1	Adaptin_N	17..562	CDD:279882	125/583 (21%)
		Coatamer_beta_C	678..820	CDD:285019	31/161 (19%)
		Coatomer_b_Cpla	826..953	CDD:291472	21/107 (20%)
AP1B1	NP_001118.3	Adaptin_N	11..534	CDD:396262	121/565 (21%)
		HEAT repeat	51..75	CDD:293787	4/24 (17%)
		HEAT repeat	87..114	CDD:293787	6/26 (23%)
		HEAT repeat	121..151	CDD:293787	8/29 (28%)
		HEAT repeat	160..186	CDD:293787	6/25 (24%)
		HEAT repeat	197..228	CDD:293787	5/31 (16%)
		HEAT repeat	355..379	CDD:293787	7/29 (24%)
		HEAT repeat	391..419	CDD:293787	2/27 (7%)
		HEAT repeat	427..458	CDD:293787	9/30 (30%)
		HEAT repeat	464..490	CDD:293787	4/25 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..625		11/45 (24%)
		Alpha_adaptinC2	726..826	CDD:197886	16/76 (21%)
		B2-adapt-app_C	835..948	CDD:198088
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810