DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment betaCOP and Ap3b2

DIOPT Version :9

Sequence 1:NP_523400.1 Gene:betaCOP / 32820 FlyBaseID:FBgn0008635 Length:964 Species:Drosophila melanogaster
Sequence 2:XP_006540634.1 Gene:Ap3b2 / 11775 MGIID:1100869 Length:1101 Species:Mus musculus


Alignment Length:1074 Identity:210/1074 - (19%)
Similarity:375/1074 - (34%) Gaps:253/1074 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 LKRDLEKGDTNVKIETLKRVIKLLLNGERYPGLIMTIIRFVLPVQNHTIKKLLLIFWEIVPKTSA 88
            ||..|:....::|:|.:||::.::..|:....|...:::.| ..:|..:|||:.::.....:...
Mouse    42 LKEMLDTNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNV-ACKNIEVKKLVYVYLVRYAEEQQ 105

  Fly    89 DGKLLQEMILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPELLEPLMPAIRACLDHRHSYVRRNA 153
            |..||.     ...:::.|:.||:.:|.|.||.|..::.|.::..:|.||:........|||:.|
Mouse   106 DLALLS-----ISTFQRGLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTA 165

  Fly   154 VLAIFTIY-----------KNFDWLVPDGPELIASFLDTQQDMSCKRNAFLMLLHADQERALNYL 207
            ..||..:|           :..:.|:.|...|:|..:....:..|...  :.|:|.:..:..|.|
Mouse   166 AHAIPKLYSLDSDQKDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPER--IDLIHKNYRKLCNLL 228

  Fly   208 ASCIDQVHTFGDILQLVIVELIYKVCHANPAERSRFIRCIYN--LLNSSSNAVRY---------- 260
               || |..:|   |:||:.::.:..      |::|:....|  ||..:.....|          
Mouse   229 ---ID-VEEWG---QVVIISMLTRYA------RTQFLSPTQNESLLEENPEKAFYGSEEDEAKGP 280

  Fly   261 --ESAGTL-----------------------ITLSLAPTAIKAAASCYIELVVK----------- 289
              |.|.|.                       :..|.:...:.|.|..|..|..|           
Mouse   281 GSEEAATAALPARKPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQLYFHLAPKAEVGVIAKALV 345

  Fly   290 ---ESDNNVKLIVLDRLVAMK-EHEGM-EKVMQDLVMDVLRVLAAPDIEVRRKTLALALDLVYSR 349
               .|.:.|:.:||..:..|. :..|| |..::...     :.:....:::...|.:..:|....
Mouse   346 RLLRSHSEVQYVVLQNVATMSIKRRGMFEPYLKSFY-----IRSTDPTQIKILKLEVLTNLANET 405

  Fly   350 NIGEMVLVLKKEVAKTHNVEHEDTGKYRQLLVRTLHTCSIKFPDVAANVIPVLVEFLSDTNELAA 414
            ||   ..||::......:::.:    :....::.:..|:.....|....:..||:.||:.:||..
Mouse   406 NI---PTVLREFQTYIRSMDKD----FVAATIQAIGRCATNIGRVRDTCLNGLVQLLSNRDELVV 463

  Fly   415 ADVLIFIREAIQKFPALRALIIEHLIEAFPQIKSSKIHRAAVWILGEYVEGSQILEVIAVIQQTL 479
            |:.::.|::.:|..||....||:||.:....|:......:.:|::|||.|               
Mouse   464 AESVVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASILWLIGEYCE--------------- 513

  Fly   480 GEVPMVEAE-QRRLAGDQTEEQ---KQQQGSAGGNAAGSAAEGSGSGNASNKVTSDGTYATQSAY 540
             .||.:..: .|::|...|.|:   |.|       ....||:...:.:...|:      .||...
Mouse   514 -HVPKIAPDVLRKMAKSFTAEEDIVKLQ-------VINLAAKLYLTNSKQTKL------LTQYVL 564

  Fly   541 SLAP-----------------VAKAEK-----------------RPPLRQYLMDGDFFIGAALSA 571
            |||.                 :..:|:                 .|.|.....|.|.|...:||.
Mouse   565 SLAKYDQNYDIRDRARFTRQLIVPSEQGGALSRHAKKLFLAPKPAPILESSFKDRDHFQLGSLSH 629

  Fly   572 TLTKLALRYAEL------ETEARAQNRLTTQVMLIMSSILHLG---------------KSGFPSK 615
            .|...|..|.||      ..:...:|.....:.||.:.:..||               |.....|
Mouse   630 LLNAKATGYQELPDWPEEAPDPSVRNVEEEDLSLIETHVGLLGEYTEVPEWTKCSNREKRKEKEK 694

  Fly   616 PITNDDTDRIFVCLRTLSERTPEAISVFTLYCREALGKMLDAQHDEDQRMLK------------- 667
            |..:|............||...|:.|..........|:......:|::...|             
Mouse   695 PFYSDSEGESGPTESADSEPESESESESKSSSGSGSGESSSESDNEEEDEEKGGGSESEQSEEED 759

  Fly   668 EKQKATAKVQPDDPVLFAQLSNGRDNQLGENVFESSLNQALAGSKNAQLSDVA-----SPNSKLN 727
            ||:|.|.|.:..:     ....|..::.|.:...||.::..:.|:..|:...:     .|.||..
Mouse   760 EKKKKTKKKKASE-----GHREGSSSEEGSDSSSSSESEVTSESEEEQVEPASWRKKTPPGSKSA 819

  Fly   728 KVTQ------LTGFSDP-VYAEAYVNVNQYDIVLDVLIVNQTNDTLQNCTLE-LATLGDLKLVER 784
            .|.:      |..|:.| |...:...|....:..|:..:..|:.:|....|. ::::|..:|:.|
Mouse   820 PVAKEISLLDLEDFTPPSVQPVSPPMVVSTSLAADLEGLTLTDSSLVPSLLSPVSSIGRQELLHR 884

  Fly   785 --------------------PHPVVLAPHDFCN-----IKA-NVKVSSTENGIIFGNIVYETALN 823
                                ||.|.|..: |.|     ||. :|.......||.........:|.
Mouse   885 VAGEGLSVDYAFSRQPFSGDPHMVSLHIY-FSNNSETPIKGLHVGTPKLPAGISIQEFPEIESLA 948

  Fly   824 TNVVVLNTIHIDIMDYIIPAS---CTDTEFRQMWQDFEWENKVTVNTSFTDLHEYLKHLLKSTNM 885
            ........:.|:..|....|:   ||.|  ||.:...:......:...|...:|:.|...|.|.|
Mouse   949 PGESTTTVMGINFCDSTQAANFQLCTQT--RQFYVSIQPPVGELMAPVFMSENEFKKEQGKLTGM 1011

  Fly   886 KCLTPEKALSGQCGFMAANMYAKSIFGENALANL 919
            ..:|.:..|...|  .:.:|..:.:   .|.|||
Mouse  1012 NEITEKLTLPDTC--RSDHMVVQKV---TATANL 1040

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
betaCOPNP_523400.1 Adaptin_N 17..562 CDD:279882 124/639 (19%)
Coatamer_beta_C 678..820 CDD:285019 33/180 (18%)
Coatomer_b_Cpla 826..953 CDD:291472 22/97 (23%)
Ap3b2XP_006540634.1 Adaptin_N 34..590 CDD:366724 120/609 (20%)
HEAT repeat 111..139 CDD:293787 8/32 (25%)
HEAT repeat 145..173 CDD:293787 9/27 (33%)
HEAT repeat 182..208 CDD:293787 4/25 (16%)
AP3B1_C 823..966 CDD:373301 26/143 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5096
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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