Protein Alignment betaCOP and ap3b2

DIOPT Version :9

• Sequence 1: NP_523400.1
• Gene: betaCOP / 32820
• FlyBaseID: FBgn0008635
• Length: 964
• Species: Drosophila melanogaster
• Sequence 2: XP_021326282.1
• Gene: ap3b2 / 100000165
• -ID: -
• Length: 1091
• Species: Danio rerio
• Alignment Length: 1109
• Identity: 219/1109 - (19%)
• Similarity: 395/1109 - (35%)
• Gaps: 303/1109 - (27%)

  Fly    28 LEKGDTNVKIETLKRVIKLLLNGERYPGLIMTIIRFVLPVQNHTIKKLLLIFWEIVPKTSADGKL 92
            |:....::|:|.:||::.::..|:....|...:::.| ..:|..:|||:.::.....:...|..|
Zfish     2 LDSNKDSLKLEAMKRIVAMIARGKNASDLFPAVVKNV-ACKNIEVKKLVYVYLVRYAEEQQDLAL 65

  Fly    93 LQEMILVCDAYRKDLQHPNEFLRGSTLRFLCKLKEPELLEPLMPAIRACLDHRHSYVRRNAVLAI 157
            |.     ...:::.|:.||:.:|.|.||.|..::...::..:|.||:........|||:.|..||
Zfish    66 LS-----ISTFQRGLKDPNQLIRASALRVLSSIRVTIIVPIMMLAIKEAASDMSPYVRKTAAHAI 125

  Fly   158 FTIY-----------KNFDWLVPDGPELIASFLDTQQDMSCKRNAFLMLLHADQERALNYLASCI 211
            ..::           :..:.|:.|...|:|..:....:..|...  :.|:|.:..:..|.|   |
Zfish   126 PKLHSLDPDQKDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPDR--IDLIHKNYRKLCNLL---I 185

  Fly   212 DQVHTFGDILQLVIVELIYKVCHANPAERSRFIRCIYN--LLNSSSNAVRYES-----------A 263
            | |..:|   |:||:.::.:..      |::|:....|  ||...|....|.|           |
Zfish   186 D-VEEWG---QVVIINMLTRYA------RTQFLNPNINESLLEEGSEKAFYASDDEEDEDKKAEA 240

  Fly   264 GTL---------------------ITLSLAPTAIKAAASCYIELVVKESDNNVKLIVLDRLVAMK 307
            ..|                     :..|.....:.|.|..|..|..| ::..|....|.||  |:
Zfish   241 AALAKRKPYVMDPDHRLLLRNTKPLLQSRNAAVVMAVAQLYFHLAPK-AEVGVIAKALVRL--MR 302

  Fly   308 EHEGMEKVMQDLVMDVLRVLAAPDIEVRRKTLALALDLVYSRNIG-EMVLVLKKEV----AKTHN 367
            .|..::.|       ||:.:|...|: ||......|...|.|:.. ..:.:||.||    |...|
Zfish   303 SHSEVQYV-------VLQNVATMTIK-RRGMFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETN 359

  Fly   368 V-----EHEDTGK-----YRQLLVRTLHTCSIKFPDVAANVIPVLVEFLSDTNELAAADVLIFIR 422
            :     |.:...|     :....::.:..|:....:|....:..||:.||:.:||..|:.::.|:
Zfish   360 ISTILREFQTYIKSMDKDFVAASIQAIGRCATNIGEVRDTCLNGLVQLLSNRDELVVAESVVVIK 424

  Fly   423 EAIQKFPALRALIIEHLIEAFPQIKSSKIHRAAVWILGEYVEGSQILEVIAVIQQTLGEVPMVEA 487
            :.:|..|...:.||:|:.:....|:......:.:|::|||.|                .||.:..
Zfish   425 KLLQMQPEQHSDIIKHMAKLIDNIQVPMARASILWLIGEYCE----------------HVPKIAP 473

  Fly   488 E-QRRLAGDQTEEQ---KQQQGSAGGNAAGSAAEGSGSGNASNKVTS---------DGTY----- 534
            : .|::|...|.|:   |.|       ....||:...:.:...|:.:         |..|
Zfish   474 DVLRKMAKTFTNEEDIVKLQ-------IINLAAKLYLTNSKQTKLLTQYVLNLAKYDQNYDIRDR 531

  Fly   535 ---------ATQSAYSLAPVAK-----AEKRPPLRQYLMDGDFFIGAALSATLTKLALRYAEL-- 583
                     .|..:.:|:..||     .:..|.|.....|.|.|...:||..|...|..|.||
Zfish   532 ARFIRQLIVPTDKSGALSKYAKKLFLALKPAPVLESPFKDRDHFQLGSLSHLLNAKASGYQELPD 596

  Fly   584 -----------ETEA-RAQNRLTTQVMLIMSSILHLGK--------------------------- 609
                       ..|. |...|:||     ::||....|
Zfish   597 WPESAPDPSVRNVEVIRLLERVTT-----LTSIPEWSKCTSRKDRKEKKVEKPFYSDSEGESGPT 656

  Fly   610 --------SGFPSKPITNDDTDRIFVCLRTLSERTPEAISVFTLYCREALGKMLDAQH----DED 662
                    ||..|:..:..:..|   ..|:.||             .|..|:..:::.    :||
Zfish   657 ESADSESDSGSGSESASGSEESR---SARSGSE-------------SEDSGEESESEEEEEDEED 705

  Fly   663 QRMLKEK-QKATAKVQPDDPVLFAQLSNGRDNQLGENVF--ESSLNQALAGSKNAQLSD------ 718
            |:..|:: :|..|:...::.....|.|...|.:....:.  :.|::::.:.|::::..:
Zfish   706 QKKKKKRLEKTKARKAVEESAESEQSSGAEDRKRSRKMVKNQKSVSESDSESESSESEEESEEES 770

  Fly   719 ----------------VASP--------NSKLNKVTQLTGFSD--PVYAEA---YVNVNQYDIVL 754
                            |:.|        :.|.||...|....|  |..|.|   .||.....:|.
Zfish   771 EEESESDTDIRKKKAPVSKPPPKPSKKESKKENKEMSLLDLDDFEPAPASAPVTPVNFLSSSLVS 835

  Fly   755 DVLIVNQTNDTLQNCTLELATLGDLKLVERPHPVV---LAPHDFC----------NIKANVKVSS 806
            |:..::.|:..|...|  :|..|.:|:.|..|.:.   ||. ::|          |:.| |::..
Zfish   836 DLEGLSLTDTILAPTT--IAPSGSIKMYELLHRITGEGLAV-EYCFSRQPFSPDPNMVA-VQIQF 896

  Fly   807 TEN-----------------GIIFGNIVYETALNTNVVVLNTIHIDIMDYIIPAS---CTDTEFR 851
            |.|                 |:..........|..|..|...:.||..|....|:   ||.|  |
Zfish   897 TNNTNAETKNLHIEEPRLQSGMRIREFSEIEVLAANESVTVVMGIDFCDSTQAANFQLCTHT--R 959

  Fly   852 QMWQDFEWENKVTVNTSFTDLHEYLKHLLKSTNMKCLTPEKALSGQCGFMAANMYAKSIFGENAL 916
            :.:...:......:..:|...:::.|...|...|..::.:..|..:|  :..::..:.:   .|.
Zfish   960 KFYVSIQPPVGELMTPAFLTENDFKKEQGKLMGMNEISEKLTLGDKC--VNEHVIVERV---TAT 1019

  Fly   917 ANLS 920
            ||||
Zfish  1020 ANLS 1023

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
betaCOP	NP_523400.1	Adaptin_N	17..562	CDD:279882	129/625 (21%)
		Coatamer_beta_C	678..820	CDD:285019	36/208 (17%)
		Coatomer_b_Cpla	826..953	CDD:291472	20/98 (20%)
ap3b2	XP_021326282.1	Adaptin_N	1..543	CDD:307641	122/595 (21%)
		HEAT repeat	67..94	CDD:293787	8/31 (26%)
		HEAT repeat	101..131	CDD:293787	9/29 (31%)
		HEAT repeat	138..164	CDD:293787	4/25 (16%)
		AP3B1_C	806..948	CDD:317233	32/145 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910