DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6179 and NOSIP

DIOPT Version :9

Sequence 1:	NP_573288.1	Gene:	CG6179 / 32819	FlyBaseID:	FBgn0030915	Length:	307	Species:	Drosophila melanogaster
Sequence 2:	XP_024307296.1	Gene:	NOSIP / 51070	HGNCID:	17946	Length:	348	Species:	Homo sapiens

Alignment Length:	358	Identity:	157/358 - (43%)
Similarity:	204/358 - (56%)	Gaps:	62/358 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTRHARNCTAGAVYTYNEKKRDAAESGYGTNAQRLGKDSVKSFDCCSLTLQPCRRPVITKDGYLF 65
            ||||.:||||||||||:|||:|.|.|||||...||.:|:||.||||.|:||||..||:|.||||:
Human     2 MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFDCCCLSLQPCHDPVVTPDGYLY 66

  Fly    66 DKEAILQYIVTKKNEYSRRLKEYERLR--RAEEDKLSQEANSKQQARMERFVNAEKPAMTPAHSS 128
            ::||||:||:.:|.|.:|::|.||:.|  |.||.|..|.|.|:...|  .|:..|         |
Human    67 EREAILEYILHQKKEIARQMKAYEKQRGTRREEQKELQRAASQDHVR--GFLEKE---------S 120

  Fly   129 AAASE--KPSTSSAAAAASSES-SSASSISNMTNGHEKKLPSFWLPSECPNAGLAKAQKP----- 185
            |..|.  .|.|:.|.:..|.:. ....|:...:...:|.|||||:||..|.|...|.:||
Human   121 AIVSRPLNPFTAKALSGTSPDDVQPGPSVGPPSKDKDKVLPSFWIPSLTPEAKATKLEKPVSPHS 185

  Fly   186 -----------------------------------------DATIYCPVSQKPLRVKDLIDVKFT 209
                                                     ..|:.||:|.||||:.||..|.||
Human   186 APARTVPGRQGSPPSSSRTGTTRSPPAPALPTEPASLCPLQSRTVTCPMSGKPLRMSDLTPVHFT 250

  Fly   210 LLKDGDTKRSLIAKEARYMCPITHDVLSNAVPCAVLRPTGDVVTMECVERLIRKDMIHPLTDRKL 274
            .|.....:..||.:..||:|.:|.|.||||.|||||||:|.|||:||||:||||||:.|:|..||
Human   251 PLDSSVDRVGLITRSERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVTGDKL 315

  Fly   275 KEKDIIPLQRGGTGYATTNDHLQAKEKRPMLQA 307
            .::|||.|||||||:|.:...|||::.||::||
Human   316 TDRDIIVLQRGGTGFAGSGVKLQAEKSRPVMQA 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6179	NP_573288.1	zf-NOSIP	4..78	CDD:292528	48/73 (66%)
CG6179	NP_573288.1	RING	<200..>282	CDD:302633	45/81 (56%)
NOSIP	XP_024307296.1	zf-NOSIP	5..79	CDD:318178	48/73 (66%)
		Herpes_ICP4_C	139..>282	CDD:332854	40/142 (28%)
		RING-Ubox2_NOSIP	267..331	CDD:319576	44/63 (70%)
		U-box domain, a modified RING finger	270..311	CDD:319576	29/40 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152576
Domainoid	1	1.000	181	1.000	Domainoid score	I3489
eggNOG	1	0.900	-	-		E1_KOG3039
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9315
Inparanoid	1	1.050	296	1.000	Inparanoid score	I2746
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54655
OrthoDB	1	1.010	-	-		D1567031at2759
OrthoFinder	1	1.000	-	-		FOG0006373
OrthoInspector	1	1.000	-	-		oto90133
orthoMCL	1	0.900	-	-		OOG6_103091
Panther	1	1.100	-	-	LDO	PTHR13063
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2684
SonicParanoid	1	1.000	-	-		X4634
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800