DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CrebB and CREB3L3

DIOPT Version :9

Sequence 1:	NP_001334685.1	Gene:	CrebB / 32817	FlyBaseID:	FBgn0265784	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_115996.1	Gene:	CREB3L3 / 84699	HGNCID:	18855	Length:	461	Species:	Homo sapiens

Alignment Length:	346	Identity:	74/346 - (21%)
Similarity:	108/346 - (31%)	Gaps:	132/346 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GGGGGGGNPQQQQQNPQ-----STTAGG----PTGATNNAQG--GGVSSVLTTTANCNIQYPIQT 93
            |.|.|....||...||.     |:..|.    |:....:.:|  .|:|..|.:..
Human    43 GEGWGHVKDQQVLPNPDSDDFLSSILGSGDSLPSSPLWSPEGSDSGISEDLPSDP---------- 97

  Fly    94 LAQHGLQVQSVIQANP--SGVIQTAAGTQQQQQALAAATAMQKVVYVAKPPNSTVIHTTPGNAVQ 156
                        |..|  ||...:.||....|..        |...::..|.::...||||..:|
Human    98 ------------QDTPPRSGPATSPAGCHPAQPG--------KGPCLSYHPGNSCSTTTPGPVIQ 142

  Fly   157 VRNKI-----------------PPTFPCKIKPEPNTQHPEDSDESLSDDDSQHHR---------- 194
            |....                 .|..|..:.|..|....:......|.|..|||.
Human   143 VPEASVTIDLEMWSPGGRICAEKPADPVDLSPRCNLTVKDLLLSGSSGDLQQHHLGASYLLRPGA 207

  Fly   195 ---SELTRRPSYNKIFTEISGPDMSGASLPMSDGVLNSQLAGTGAGGNAANSSLMQLDPTYYLSN 256
               .||.......|:..:      .|.:||                        .||..|.|
Human   208 GHCQELVLTEDEKKLLAK------EGITLP------------------------TQLPLTKY--- 239

  Fly   257 RMSYNTNNSGIAEDQTRKREIRLQKNREAARECRRKKKEYIKCLENRVAV--------------L 307
                        |::..|:..|..:|:::|:|.|:||||||..||.|::.              |
Human   240 ------------EERVLKKIRRKIRNKQSAQESRKKKKEYIDGLETRMSACTAQNQELQRKVLHL 292

  Fly   308 ENQNKALIEELKSLKELYCQT 328
            |.||.:|:|:||.|:.:..|:
Human   293 EKQNLSLLEQLKKLQAIVVQS 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrebB	NP_001334685.1	None
CREB3L3	NP_115996.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..120		18/98 (18%)
		DUF2207	<169..>266	CDD:303056	27/141 (19%)
		bZIP_CREB3	244..304	CDD:269837	21/59 (36%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	245..274		14/28 (50%)
		coiled coil	246..297	CDD:269837	17/50 (34%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	285..306		8/20 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..408
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..461
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144438
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930