DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CrebB and CREB3L2

DIOPT Version :9

Sequence 1:	NP_001334685.1	Gene:	CrebB / 32817	FlyBaseID:	FBgn0265784	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_919047.2	Gene:	CREB3L2 / 64764	HGNCID:	23720	Length:	520	Species:	Homo sapiens

Alignment Length:	265	Identity:	63/265 - (23%)
Similarity:	103/265 - (38%)	Gaps:	68/265 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 LQVQSVIQANPSGVIQTAAGTQQQQQALAAATAMQKVVYVAKPP---NSTV----------IHTT 150
            ::.:.|....|.|::.:...|     ..|.:|.::|    .:||   |:.|          |...
Human   125 IKTEPVTDEPPPGLVPSVTLT-----ITAISTPLEK----EEPPLEMNTGVDSSCQTIIPKIKLE 180

  Fly   151 PGNAVQVRNKIPPTFP---CKIKPEPNTQHPEDSDESLSDDDSQHHRS-ELTRRPSYNKIFTEIS 211
            |....|..|..|...|   ..:.|.|.:.|..||:.|||.:...|..| ..|..||
Human   181 PHEVDQFLNFSPKEAPVDHLHLPPTPPSSHGSDSEGSLSPNPRLHPFSLPQTHSPS--------- 236

  Fly   212 GPDMSGASLPMSDGVLNS--------QLAGTGAGGNAANSSLMQLDPTYYLSNRMSYNTNNSGIA 268
                  .:.|.:...|:|        :|.|:|............:...|.:..::..:.     :
Human   237 ------RAAPRAPSALSSSPLLTAPHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLSK-----S 290

  Fly   269 EDQTRKREIRLQKNREAARECRRKKKEYIKCLE--------------NRVAVLENQNKALIEELK 319
            |::..|:..|..||:.:|:|.|||||||:..||              .:|.||||.|:.|:::|:
Human   291 EEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQ 355

  Fly   320 SLKEL 324
            .|:.|
Human   356 KLQTL 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrebB	NP_001334685.1	None
CREB3L2	NP_919047.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..264		20/83 (24%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	296..325		15/28 (54%)
		bZIP_CREB3	305..348	CDD:269837	16/42 (38%)
		coiled coil	305..348	CDD:269837	16/42 (38%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	336..357		8/20 (40%)
		S1P recognition. /evidence=ECO:0000303\|PubMed:17178827	427..430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144428
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930