DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CrebB and Creb3l2

DIOPT Version :9

Sequence 1:	NP_001334685.1	Gene:	CrebB / 32817	FlyBaseID:	FBgn0265784	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_001012188.1	Gene:	Creb3l2 / 362339	RGDID:	1306040	Length:	521	Species:	Rattus norvegicus

Alignment Length:	265	Identity:	58/265 - (21%)
Similarity:	99/265 - (37%)	Gaps:	74/265 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 PSGVIQTAAGTQQQQQALAAATAMQKVVYVAKP--PNSTVIHTTPGNAVQVRNKIPPTFPCKIK- 170
            ||..|:|...|::|...|..:..: .:..::.|  ...:.:..:.|.....:..||     |||
  Rat   121 PSATIKTEPITEEQPPGLVPSVTL-TITAISTPFEKEESPLDMSAGGDSSCQTLIP-----KIKL 179

  Fly   171 ------------------------PEPNTQHPEDSDESLSDDDSQHHRSELTRRPSYNKIFTEIS 211
                                    |.|.:.|..||:.|||.:...|..|              :|
  Rat   180 EPHEVDQFLNFSPKEASVDQLHLPPTPPSSHSSDSEGSLSPNPRLHPFS--------------LS 230

  Fly   212 GPDMSGASLPMSDGVLNS--------QLAGTGAGGNAANSSLMQLDPTYYLSNRMSYNTNNSGIA 268
            .....|.::|.....|::        :|.|:|............:...|.:..::....     :
  Rat   231 QAHSPGRAMPRGPSALSTSPLLTAPHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLTK-----S 290

  Fly   269 EDQTRKREIRLQKNREAARECRRKKKEYIKCLE--------------NRVAVLENQNKALIEELK 319
            |::..|:..|..||:.:|:|.|||||||:..||              .:|.||||.|:.|:::|:
  Rat   291 EEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQ 355

  Fly   320 SLKEL 324
            .|:.|
  Rat   356 KLQTL 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrebB	NP_001334685.1	None
Creb3l2	NP_001012188.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..264		17/81 (21%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	296..325		15/28 (54%)
		bZIP_CREB3	305..348	CDD:269837	16/42 (38%)
		coiled coil	305..348	CDD:269837	16/42 (38%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	336..357		8/20 (40%)
		S1P recognition. /evidence=ECO:0000250\|UniProtKB:Q70SY1	427..430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338138
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930