DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CrebB and Atf6

DIOPT Version :9

Sequence 1:	NP_001334685.1	Gene:	CrebB / 32817	FlyBaseID:	FBgn0265784	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_001100666.1	Gene:	Atf6 / 304962	RGDID:	1305471	Length:	656	Species:	Rattus norvegicus

Alignment Length:	240	Identity:	54/240 - (22%)
Similarity:	91/240 - (37%)	Gaps:	58/240 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 QHGLQVQSVIQANPSGVIQTAAGTQQQQQALAAATAMQKVVYVAKPPNSTVIHTTPGNAVQVRNK 160
            :|||        .|...||.::....|.:.|....|.:.....:.|..:.:|.|
  Rat   149 EHGL--------TPKKKIQMSSKPSVQPKPLLLPAAPKTPANASVPAKTIIIQT----------- 194

  Fly   161 IPPTFP-------CKIKPEPNTQHPEDSDESLSDDDSQHHRSELTRRPSYNKIFTEISGPD---- 214
            :|...|       ..|:|.|.                 ..::.|..:|:..::.|....|.
  Rat   195 LPALMPLAKQQSIISIQPAPT-----------------KGQTVLLSQPAVVQLQTPGVLPSAQPV 242

  Fly   215 --MSGASLPMSDGVLNSQLAGTGAGGNAANSSLMQLDPTYYLSNRMSYNTNNSGIAEDQTRKREI 277
              ::|.:..:.:.|:|  :.......:..|..|....|....|.|    :..|.||   ..:|:.
  Rat   243 LAVTGGATQLPNHVVN--VVPAPVVNSPVNGKLCVTKPVLQSSTR----STGSDIA---VLRRQQ 298

  Fly   278 RLQKNREAARECRRKKKEYIKCLENRVAVLENQNKALIEELKSLK 322
            |:.||||:|.:.|:|||||:..||.|:....::|:.|.:|..|||
  Rat   299 RMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGSLK 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrebB	NP_001334685.1	None
Atf6	NP_001100666.1	Transcription activation. /evidence=ECO:0000305	1..137
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..171		7/29 (24%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	295..326		16/30 (53%)
		bZIP_ATF6	296..347	CDD:269848	22/48 (46%)
		coiled coil	296..347	CDD:269848	22/48 (46%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	335..342		2/6 (33%)
		Interaction with THBS4. /evidence=ECO:0000250\|UniProtKB:P18850	455..575
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	632..656
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338140
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930