DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CrebB and Atf6

DIOPT Version :9

Sequence 1:	NP_001334685.1	Gene:	CrebB / 32817	FlyBaseID:	FBgn0265784	Length:	331	Species:	Drosophila melanogaster
Sequence 2:	NP_001074773.1	Gene:	Atf6 / 226641	MGIID:	1926157	Length:	656	Species:	Mus musculus

Alignment Length:	268	Identity:	55/268 - (20%)
Similarity:	100/268 - (37%)	Gaps:	78/268 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 NCNIQYPIQTL------------AQHGLQVQSVIQANPSGVIQTAAGTQQQQQALAAATAMQKVV 136
            :||....::.|            .:|||        .|...||.::....|.:.|....|.:...
Mouse   125 SCNSPSSVEPLKEEKPVTGPGNKTEHGL--------TPKKKIQMSSKPSVQPKPLLLPAAPKTQT 181

  Fly   137 YVAKPPNSTVIHTTPGNAVQVRNKIPPTFP-------CKIKPEPNTQHPEDSDESLSDDDSQHHR 194
            ..:.|..:.:|.|           :|...|       ..|:|.|.                 ..:
Mouse   182 NASVPAKAIIIQT-----------LPALMPLAKQQSIISIQPAPT-----------------KGQ 218

  Fly   195 SELTRRPSYNKIFTEISGPDMSGASLPMSDGVLNSQLAGTGAGGNAANSSLMQLDPTYYLSNRMS 259
            :.|..:|:    ..::..|.:..::.|:        ||.||......| .::.:.|...:|:.::
Mouse   219 TVLLSQPT----VVQLQSPAVLSSAQPV--------LAVTGGAAQLPN-HVVNVLPAPVVSSPVN 270

  Fly   260 YNTN-NSGIAEDQTR---------KREIRLQKNREAARECRRKKKEYIKCLENRVAVLENQNKAL 314
            ...: ...:.:..||         :|:.|:.||||:|.:.|:|||||:..||.|:....::|:.|
Mouse   271 GKLSVTKPVLQSATRSMGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQL 335

  Fly   315 IEELKSLK 322
            .:|..|||
Mouse   336 KKENGSLK 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrebB	NP_001334685.1	None
Atf6	NP_001074773.1	Transcription activation. /evidence=ECO:0000305	1..137		3/11 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..169		10/51 (20%)
		Ribophorin_II	<223..>298	CDD:368624	13/87 (15%)
		Basic motif	295..326		16/30 (53%)
		bZIP_ATF6	296..347	CDD:269848	22/48 (46%)
		coiled coil	296..347	CDD:269848	22/48 (46%)
		Leucine-zipper	335..342		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..429
		Interaction with THBS4. /evidence=ECO:0000269\|PubMed:22682248	455..575
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	632..656
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834562
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930