Protein Alignment CrebB and CREB3L4

DIOPT Version :10

• Sequence 1: NP_001334685.1
• Gene: CrebB / 32817
• FlyBaseID: FBgn0265784
• Length: 331
• Species: Drosophila melanogaster
• Sequence 2: NP_570968.1
• Gene: CREB3L4 / 148327
• HGNCID: 18854
• Length: 395
• Species: Homo sapiens
• Alignment Length: 224
• Identity: 53/224 - (23%)
• Similarity: 93/224 - (41%)
• Gaps: 65/224 - (29%)

  Fly   168 KIKPEPN----TQHPEDSDESLSDDDSQHHRSELTRRPSYNKIFTEI-------------SGPDM 215
            |:..:||    ::....||..:|:|.. |..|....|.:.:.:..|:             :||::
Human    70 KLFIDPNEVYCSEASPGSDSGISEDPC-HPDSPPAPRATSSPMLYEVVYEAGALERMQGETGPNV 133

  Fly   216 SGASLPMS---------DGVLNSQL-----------AGTGAGGNAANSSLMQLDPTYYLSNRMSY 260
            ...|:.:.         |..:.|:|           |||.|  ....::|:... |.:|::....
Human   134 GLISIQLDQWSPAFMVPDSCMVSELPFDAHAHILPRAGTVA--PVPCTTLLPCQ-TLFLTDEEKR 195

  Fly   261 NTNNSGI----------AEDQTRKREIRLQKNREAARECRRKKKEYIKCLENRVAV--------- 306
            .....|:          ||::..|:..|..:|:::|::.||:|||||..||:|||.
Human   196 LLGQEGVSLPSHLPLTKAEERVLKKVRRKIRNKQSAQDSRRRKKEYIDGLESRVAACSAQNQELQ 260

  Fly   307 -----LENQNKALIEELKSLKELYCQTKN 330
                 ||..|.:|:.:|:.|:.|..||.|
Human   261 KKVQELERHNISLVAQLRQLQTLIAQTSN 289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CrebB	NP_001334685.1	pKID	<191..>214	CDD:396650	5/35 (14%)
		bZIP_CREB1	274..327	CDD:269838	23/66 (35%)
		coiled coil	275..327	CDD:269838	22/65 (34%)
CREB3L4	NP_570968.1	PCC	77..>154	CDD:188093	12/77 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	82..108		7/26 (27%)
		bZIP_CREB3	218..278	CDD:269837	20/59 (34%)
		Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	219..248		13/28 (46%)
		coiled coil	220..271	CDD:269837	17/50 (34%)
		Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	259..280		5/20 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..395