DRSC/TRiP Functional Genomics Resources

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Protein Alignment CrebB and ATF2

DIOPT Version :9

Sequence 1:NP_001334685.1 Gene:CrebB / 32817 FlyBaseID:FBgn0265784 Length:331 Species:Drosophila melanogaster
Sequence 2:NP_001243019.1 Gene:ATF2 / 1386 HGNCID:784 Length:505 Species:Homo sapiens


Alignment Length:309 Identity:67/309 - (21%)
Similarity:102/309 - (33%) Gaps:81/309 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 SSVLTTTANCNIQYPIQT--------LAQ-----------HGLQVQSVI--QANPSGVIQTAAGT 119
            |.|.||..:..:.:|..|        |||           ..|||.:|:  .::.|.:||.|..:
Human   127 SVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPS 191

  Fly   120 QQQQQALAAATAMQKVVYVAKPPNSTVIHTTPGNA-------------VQVRNKIPPTFPCKIKP 171
            ......:..|.:..:.:.....|...::|...|..             |.|...:|...|..:.|
Human   192 PTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVP 256

  Fly   172 E------PNTQHPEDSDESL--------------SDDDSQHHRSELTRRPSYNKIFTEISGPDMS 216
            .      |::..|..|:..:              :.|..:.|.|.|.|..|.......:..|..|
Human   257 SVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATS 321

  Fly   217 GASLPMSDGVLNSQLAGT-GAGGNAANSSLMQLDPTYYLSNRMSYNTNNSGIAEDQTRKREIRLQ 280
            ....|.|......|...| |....|||                          ||...||...|:
Human   322 TTETPASPAHTTPQTQSTSGRRRRAAN--------------------------EDPDEKRRKFLE 360

  Fly   281 KNREAARECRRKKKEYIKCLENRVAVLENQNKALIEELKSLKELYCQTK 329
            :||.||..||:|:|.:::.||.:...|.:.|..|..|:..|:....|.|
Human   361 RNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLK 409

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CrebBNP_001334685.1 None
ATF2NP_001243019.1 Nuclear export signal 1 (N-NES) 1..7
C2H2 Zn finger 27..49 CDD:275370
GCN4_cent 65..102 CDD:213399
Herpes_BLLF1 <90..342 CDD:282904 41/214 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 125..155 7/27 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 259..373 30/139 (22%)
Essential for its histone acetyltransferase activity 296..299 0/2 (0%)
bZIP_ATF2 354..414 CDD:269835 20/56 (36%)
Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 354..374 10/19 (53%)
coiled coil 355..406 CDD:269835 17/50 (34%)
Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 380..408 7/27 (26%)
Nuclear export signal 2 (C-NES) 405..414 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 425..472
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R103
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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