DRSC/TRiP Functional Genomics Resources

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Protein Alignment CrebB and Atf2

DIOPT Version :9

Sequence 1:NP_001334685.1 Gene:CrebB / 32817 FlyBaseID:FBgn0265784 Length:331 Species:Drosophila melanogaster
Sequence 2:NP_001020264.1 Gene:Atf2 / 11909 MGIID:109349 Length:487 Species:Mus musculus


Alignment Length:309 Identity:67/309 - (21%)
Similarity:102/309 - (33%) Gaps:81/309 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 SSVLTTTANCNIQYPIQT--------LAQ-----------HGLQVQSVI--QANPSGVIQTAAGT 119
            |.|.||..:..:.:|..|        |||           ..|||.:|:  .::.|.:||.|..:
Mouse   109 SVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPS 173

  Fly   120 QQQQQALAAATAMQKVVYVAKPPNSTVIHTTPGNA-------------VQVRNKIPPTFPCKIKP 171
            ......:..|.:..:.:.....|...::|...|..             |.|...:|...|..:.|
Mouse   174 PTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVP 238

  Fly   172 E------PNTQHPEDSDESL--------------SDDDSQHHRSELTRRPSYNKIFTEISGPDMS 216
            .      |::..|..|:..:              :.|..:.|.|.|.|..|.......:..|..|
Mouse   239 SVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQPATS 303

  Fly   217 GASLPMSDGVLNSQLAGT-GAGGNAANSSLMQLDPTYYLSNRMSYNTNNSGIAEDQTRKREIRLQ 280
            ....|.|......|...| |....|||                          ||...||...|:
Mouse   304 TTETPASPAHTTPQTQNTSGRRRRAAN--------------------------EDPDEKRRKFLE 342

  Fly   281 KNREAARECRRKKKEYIKCLENRVAVLENQNKALIEELKSLKELYCQTK 329
            :||.||..||:|:|.:::.||.:...|.:.|..|..|:..|:....|.|
Mouse   343 RNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLK 391

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CrebBNP_001334685.1 None
Atf2NP_001020264.1 C2H2 Zn finger 9..31 CDD:275370
GCN4_cent 47..84 CDD:213399
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 106..137 7/27 (26%)
PRK14951 <184..>312 CDD:237865 21/127 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 241..355 30/139 (22%)
Essential for its histone acetyltransferase activity. /evidence=ECO:0000250 278..281 0/2 (0%)
bZIP_ATF2 336..396 CDD:269835 20/56 (36%)
Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 336..356 10/19 (53%)
coiled coil 337..388 CDD:269835 17/50 (34%)
Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 362..390 7/27 (26%)
Nuclear export signal. /evidence=ECO:0000250 387..396 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 407..453
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R103
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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