DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CrebB and CREB3

DIOPT Version :9

Sequence 1:NP_001334685.1 Gene:CrebB / 32817 FlyBaseID:FBgn0265784 Length:331 Species:Drosophila melanogaster
Sequence 2:NP_006359.3 Gene:CREB3 / 10488 HGNCID:2347 Length:371 Species:Homo sapiens


Alignment Length:195 Identity:43/195 - (22%)
Similarity:74/195 - (37%) Gaps:60/195 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   159 NKIPPTFPCKIKPEPNTQHPEDS------DESLSDDDSQ---HHRSELTRRPSYNKIFTEISGPD 214
            |.:..:.||.:..:.....|.::      .||...:.:|   .|..||..:.....:.|:     
Human    65 NILSSSNPCLVHHDHTYSLPRETVSMDLESESCRKEGTQMTPQHMEELAEQEIARLVLTD----- 124

  Fly   215 MSGASLPMSDGVLNSQLAGTGAGGNAANSSLMQLDPTYYLSNRMSYNTNNSGIAEDQTRKREIRL 279
             ...||...:|::                    |..|..|:.           .|:|..||..|.
Human   125 -EEKSLLEKEGLI--------------------LPETLPLTK-----------TEEQILKRVRRK 157

  Fly   280 QKNREAARECRRKKKEYIKCLE--------------NRVAVLENQNKALIEELKSLKELYCQTKN 330
            .:|:.:|:|.|||||.|:..||              |:|.:||.||.:|:::|:.|:.:..:..|
Human   158 IRNKRSAQESRRKKKVYVGGLESRVLKYTAQNMELQNKVQLLEEQNLSLLDQLRKLQAMVIEISN 222

  Fly   331  330
            Human   223  222

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CrebBNP_001334685.1 None
CREB3NP_006359.3 Transcription activation (acidic). /evidence=ECO:0000269|PubMed:10984507 1..92 4/26 (15%)
LXXLL motif 1 13..17
LXXLL motif 2 54..58
HCFC1-binding-motif (HBM) 78..81 0/2 (0%)
GlgA 85..>222 CDD:333024 38/173 (22%)
bZIP_CREB3 151..211 CDD:269837 21/59 (36%)
Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 152..184 14/31 (45%)
coiled coil 153..204 CDD:269837 18/50 (36%)
Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 192..213 8/20 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144432
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

Return to query results.
Submit another query.