DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6106 and dpysl2a

DIOPT Version :9

Sequence 1:	NP_001285403.1	Gene:	CG6106 / 32816	FlyBaseID:	FBgn0030914	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	XP_003199094.1	Gene:	dpysl2a / 798555	ZFINID:	ZDB-GENE-100914-5	Length:	573	Species:	Danio rerio

Alignment Length:	511	Identity:	111/511 - (21%)
Similarity:	193/511 - (37%)	Gaps:	124/511 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IFLGDG-----SQNALIHGGI-IVDTEGIIRRVLRSPQEVNTYLYNTESESVYDFGDLVLMPGLI 68
            |::.||     .:|.::.||: |::..|                             .:|:||.|
Zfish    36 IYMEDGVIKQIGENLIVPGGVKIIEAHG-----------------------------RMLIPGGI 71

  Fly    69 DPNVHINEP--GRKDWEGFATATKAAAAGGFTTIIDRPTNAQPPTVSVAHLKA---------KTS 122
            |.:.....|  |....:.|...|:||.|||.|.|:|...    |....:.:.|         :.|
Zfish    72 DVHTRFQMPDRGMTAADDFYQGTRAALAGGTTMIMDHVV----PEPGFSLISAFNQWREWADQKS 132

  Fly   123 TARGKIYVDVGFWGGLVPGNGDQLAALL-GAGVMGLQCTLCDPAAPVSQEFPAVNESQLEEALSQ 186
            .....::||:..|.   .|..:::..|: ..||......|      ..::...:|:||:.|..|.
Zfish   133 CCDYSLHVDITEWH---KGLQEEIEMLVKDHGVNSFLVYL------AYKDIFQLNDSQMYEVFSV 188

  Fly   187 LDKDQAEGEAIVAVHAELPLTTEIHPD---EEAPREYGT-------FLVTRPPQMEISATQLLCR 241
            : :|..   ||..||||       :.|   ||..|..|.       .:::||.::|..|......
Zfish   189 I-RDLG---AIAQVHAE-------NGDIIAEEQKRILGLGITGPEGHVLSRPEEVEAEAVNRAVT 242

  Fly   242 LANRHPRRC-IHILNCSSGESLPLVEECRRQGGNLTVDTCPHYLALAAEDVPDCGTEF--KTW-- 301
            :||:  ..| ::|....|..:..::.:.|::|      |..:...::|....| ||.:  |.|
Zfish   243 IANQ--TNCPLYITKVMSKSAADVIAQARKKG------TVVYGEPISASLGTD-GTHYWSKNWAK 298

  Fly   302 -------PPIRERRNQEQLWQALRPGGAIRMIGSDHSPATPGARALTCGRGRGNFLKAWPGINSL 359
                   ||:...........:|...|.:::.||.|.......||:    |:.||.....|.|..
Zfish   299 AAAFITSPPLSPDPTTPDYLNSLLACGDLQVTGSAHCTFNTSQRAV----GKDNFTFIPEGTNGT 359

  Fly   360 QLSLSVVW-----TAAANRRGSANLTIADIHRLMCQEPANLCGLSASKGRIAEGYDADFCVWSPE 419
            :..:|::|     |...:......:|..:        .|.:..|...|||||.|.|||..:|.|:
Zfish   360 EERMSIIWDKCVVTGKMDENQFVLVTSTN--------AAKIFNLYPRKGRIAVGSDADLVLWDPD 416

  Fly   420 EEFTVGPELLYTATKATPYAGQKLRGVVHATVVRGLHVYQQ-----FEGFGQPLGK 470
            ....:..:..:.|.:...:.|.::||.....:.:|..|.::     .||.|:.:.:
Zfish   417 ATKIISAKSHHLAVEYNIFEGMEVRGAPLVVISQGKVVLEEGNLHTTEGSGRYISR 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6106	NP_001285403.1	L-HYD_ALN	2..473	CDD:238640	111/511 (22%)
dpysl2a	XP_003199094.1	PRK09060	18..468	CDD:181632	110/505 (22%)
dpysl2a	XP_003199094.1	D-HYD	18..467	CDD:238639	110/504 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D719800at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920