DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6106 and dpysl2b

DIOPT Version :9

Sequence 1:	NP_001285403.1	Gene:	CG6106 / 32816	FlyBaseID:	FBgn0030914	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	XP_005155688.1	Gene:	dpysl2b / 553412	ZFINID:	ZDB-GENE-031105-1	Length:	643	Species:	Danio rerio

Alignment Length:	505	Identity:	117/505 - (23%)
Similarity:	198/505 - (39%)	Gaps:	97/505 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LGDGSQNALIHGGIIVD-----------TEGIIRRV---LRSPQEVNTYLYNTESESVYDFGDLV 62
            |.|.|...||.|..||:           .:|:|:::   |..|..|.|          .|....:
Zfish    81 LNDESDRLLIKGAKIVNDDQSFCADIYMEDGLIKQIGENLIVPGGVKT----------IDAHGRM 135

  Fly    63 LMPGLIDPNVHINEP--GRKDWEGFATATKAAAAGGFTTIIDRPTNAQPPTVSVAHLKAKTSTAR 125
            :|||.||.:.....|  |....:.|...|:||.|||.|.|:|... .:|.|..::........|.
Zfish   136 VMPGGIDVHTRFQMPDRGMTAADDFYQGTRAALAGGTTMIVDHVV-PEPGTSLISAFNQWREWAD 199

  Fly   126 GK------IYVDVGFWGGLVPGNGDQLAALL-GAGVMGLQCTLCDPAAPVSQEFPAVNESQLEEA 183
            .|      ::||:..|.   .|..:::.||: ..||......|      ..::|..:.:||:.|.
Zfish   200 SKACCDYSLHVDITEWH---KGVQEEMEALVKDHGVNSFLVYL------AYKDFFQLTDSQIYEV 255

  Fly   184 LSQLDKDQAEGEAIVAVHAELPLTTEIHPDEE---------APREYGTFLVTRPPQMEISATQLL 239
            .|.: :|..   ||..||||   ..:|..:|:         .|..:   :::||.::|..|....
Zfish   256 FSVI-RDLG---AIAQVHAE---NGDIIAEEQRRILDLGITGPEGH---VLSRPEEVEAEAVNRS 310

  Fly   240 CRLANRHPRRC-IHILNCSSGESLPLVEECRRQGGNLTVDTCPHYLALAAEDVPDCGTEF--KTW 301
            ..:||:  ..| ::|....|..:..::.:.|::|      |..:...:.|....| |:.:  |.|
Zfish   311 VTVANQ--TNCPLYITKVMSKSAADVIAQARKKG------TVVYGEPITASIGTD-GSHYWSKNW 366

  Fly   302 ---------PPIRERRNQEQLWQALRPGGAIRMIGSDHSPATPGARALTCGRGRGNFLKAWPGIN 357
                     ||:...........:|...|.:::.||.|.......||:    |:.:|.....|.|
Zfish   367 AKAAAYVTSPPLSPDPTTPDYLNSLLSCGDLQVTGSAHCTFNTSQRAV----GKDDFTLIPEGTN 427

  Fly   358 SLQLSLSVVW-TAAANRRGSANLTIADIHRLMCQEPANLCGLSASKGRIAEGYDADFCVWSPEEE 421
            ..:..:|::| ......:...|..:|    :.....|.:..|...|||||.|.|||..:|.|:..
Zfish   428 GTEERMSIIWDKCVVTGKMDENQFVA----VTSTNAAKIFNLYPRKGRIAVGSDADLVLWDPDVT 488

  Fly   422 FTVGPELLYTATKATPYAGQKLRGVVHATVVRGLHVYQQ-----FEGFGQ 466
            ..:..:....|.:...:.|.::|||....:.:|..|.::     .||.|:
Zfish   489 KIISAKSHNLAVEYNIFEGMEVRGVPLVVISQGKIVLEEGTLHTTEGSGR 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6106	NP_001285403.1	L-HYD_ALN	2..473	CDD:238640	117/505 (23%)
dpysl2b	XP_005155688.1	PRK09060	88..538	CDD:181632	113/496 (23%)
dpysl2b	XP_005155688.1	D-HYD	88..537	CDD:238639	113/495 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0044
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D719800at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820