DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6106 and zgc:103559

DIOPT Version :9

Sequence 1:	NP_001285403.1	Gene:	CG6106 / 32816	FlyBaseID:	FBgn0030914	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001008599.1	Gene:	zgc:103559 / 494056	ZFINID:	ZDB-GENE-041212-22	Length:	459	Species:	Danio rerio

Alignment Length:	470	Identity:	199/470 - (42%)
Similarity:	272/470 - (57%)	Gaps:	34/470 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SRRIFLGDGSQNALIHGGIIVDTEGIIRRVLRSPQEVNTYLYNTESESVYDFGDLVLMPGLIDPN 71
            |:|:..|:     .|...:||..||.|..|| ...|.:.::    :..|.|.||.::|||::|.:
Zfish    12 SQRVLCGE-----KILPAVIVIKEGKIHSVL-PDSEASAHV----AGKVLDVGDSLIMPGIVDSH 66

  Fly    72 VHINEPGRKDWEGFATATKAAAAGGFTTIIDRPTNAQPPTVSVAHLKAKTSTARGKIYVDVGFWG 136
            ||:|||||.||||:.|||:||||||.|||.|.|.|..|||.::.:...|...|.|:.:||..|||
Zfish    67 VHVNEPGRTDWEGYWTATRAAAAGGITTIADMPLNTIPPTTTLRNFNEKLCAATGQCFVDTAFWG 131

  Fly   137 GLVPGNGDQLAALLGAGVMGLQCTLCDPAAPVSQEFPAVNESQLEEALSQLDKDQAEG-EAIVAV 200
            |::|||..:|..:..|||.|.:|.|.....   :|||.|.::.|..|:.||     :| .:::..
Zfish   132 GVIPGNQMELKPMCQAGVAGFKCFLIHSGV---EEFPHVTDADLHAAMKQL-----QGTNSVLLF 188

  Fly   201 HAELPLTTEIHPDEEA--PREYGTFLVTRPPQMEISATQLLCRLANRHPRRCIHILNCSSGESLP 263
            |||..|:   ||..|.  |:||.|||.:||..||:.|...:.....::..|| ||::.||.|.|.
Zfish   189 HAEQELS---HPVAEKGDPQEYSTFLKSRPDIMELEAIHTVIEFCLQYQVRC-HIVHLSSAEPLE 249

  Fly   264 LVEECRRQGGNLTVDTCPHYLALAAEDVPDCGTEFKTWPPIRERRNQEQLWQALRPGGAIRMIGS 328
            |:...::.|..|||:|..|||.|:|||:|...|:||..||||...|||.||.||: .|.|.|:.|
Zfish   250 LIRAAKQAGAPLTVETTHHYLNLSAEDIPGRATQFKCCPPIRGTANQELLWSALK-AGDIDMVVS 313

  Fly   329 DHSPATPGARALTCGRGRGNFLKAWPGINSLQLSLSVVWTAAANRRGSANLTIADIHRLMCQEPA 393
            ||||.||..:.|    ..|:|.:||.||:|||..||:.||:|:.|    ..:.:|..||:.:|||
Zfish   314 DHSPCTPDLKCL----DSGDFTQAWGGISSLQFGLSLFWTSASKR----GFSFSDAARLLREEPA 370

  Fly   394 NLCGLSASKGRIAEGYDADFCVWSPEEEFTVGPELLYTATKATPYAGQKLRGVVHATVVRGLHVY 458
            .||.|...||.:..|:|||..:|.||:||||..:.::...|.|||..:.|||:|...:|||..||
Zfish   371 RLCRLDNQKGSLIPGHDADLVIWDPEKEFTVKEDNIHHKNKLTPYLDRVLRGMVRFPIVRGQVVY 435

  Fly   459 QQFEGFGQPLGKVLL 473
            .......|||||.||
Zfish   436 SHGSFSSQPLGKHLL 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6106	NP_001285403.1	L-HYD_ALN	2..473	CDD:238640	197/468 (42%)
zgc:103559	NP_001008599.1	metallo-dependent_hydrolases	10..450	CDD:294200	197/468 (42%)
zgc:103559	NP_001008599.1	PRK09060	26..447	CDD:181632	191/446 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575843
Domainoid	1	1.000	326	1.000	Domainoid score	I1162
eggNOG	1	0.900	-	-		E1_COG0044
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39357
Inparanoid	1	1.050	347	1.000	Inparanoid score	I2283
OMA	1	1.010	-	-		QHG55564
OrthoDB	1	1.010	-	-		D379098at33208
OrthoFinder	1	1.000	-	-		FOG0008344
OrthoInspector	1	1.000	-	-		oto41373
orthoMCL	1	0.900	-	-		OOG6_101673
Panther	1	1.100	-	-	LDO	PTHR43668
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16860
SonicParanoid	1	1.000	-	-		X6324
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800