DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6106 and CRMP1

DIOPT Version :9

Sequence 1:	NP_001285403.1	Gene:	CG6106 / 32816	FlyBaseID:	FBgn0030914	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001014809.1	Gene:	CRMP1 / 1400	HGNCID:	2365	Length:	686	Species:	Homo sapiens

Alignment Length:	508	Identity:	124/508 - (24%)
Similarity:	210/508 - (41%)	Gaps:	95/508 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SQNALIHGGIIVD-----------TEGIIRRV---LRSPQEVNTYLYNTESESVYDFGDLVLMPG 66
            |...||.||.|::           .:|:|:::   |..|..|.|...|         |.:|: ||
Human   128 SDRLLIKGGRIINDDQSLYADVYLEDGLIKQIGENLIVPGGVKTIEAN---------GRMVI-PG 182

  Fly    67 LIDPNVHINEP--GRKDWEGFATATKAAAAGGFTTIID----RPTNAQPPTVSVAHLKAKT-STA 124
            .||.|.::.:|  |....:.|...|:||..||.|.|||    .|.::...:....|..|.| |..
Human   183 GIDVNTYLQKPSQGMTAADDFFQGTRAALVGGTTMIIDHVVPEPGSSLLTSFEKWHEAADTKSCC 247

  Fly   125 RGKIYVDVGFWGGLVPGNGDQLAALL-GAGVMGLQCTLCDPAAPVSQEFPAVNESQLEEALSQLD 188
            ...::||:..|   ..|..::|..|: ..||...|..:      ..::...:::|||.||.:.|
Human   248 DYSLHVDITSW---YDGVREELEVLVQDKGVNSFQVYM------AYKDVYQMSDSQLYEAFTFL- 302

  Fly   189 KDQAEG-EAIVAVHAE---LPLTTEIHPDEEAPREYGT-----FLVTRPPQMEISATQLLCRLAN 244
                :| .|::.||||   |     |..:::...|.|.     ..::||.::|..|......:|.
Human   303 ----KGLGAVILVHAENGDL-----IAQEQKRILEMGITGPEGHALSRPEELEAEAVFRAITIAG 358

  Fly   245 RHPRRC-IHILNCSSGESLPLVEECRRQG---------GNLTVDTCPHY----LALAAEDVPDCG 295
            |  ..| ::|....|..:..::...|::|         .:|..|. .||    .|.||
Human   359 R--INCPVYITKVMSKSAADIIALARKKGPLVFGEPIAASLGTDG-THYWSKNWAKAA------- 413

  Fly   296 TEFKTWPPIRERRNQEQLWQALRPGGAIRMIGSDHSPATPGARALTCGRGRGNFLKAWPGINSLQ 360
             .|.|.||:...........:|...|.:::.||.|.|.:...:|:    |:.||.....|:|.::
Human   414 -AFVTSPPLSPDPTTPDYLTSLLACGDLQVTGSGHCPYSTAQKAV----GKDNFTLIPEGVNGIE 473

  Fly   361 LSLSVVW-TAAANRRGSANLTIADIHRLMCQEPANLCGLSASKGRIAEGYDADFCVWSPEEEFTV 424
            ..::||| .|.|..:...|..:|    :.....|.:..|...|||||.|.|||..:|.|::..|:
Human   474 ERMTVVWDKAVATGKMDENQFVA----VTSTNAAKIFNLYPRKGRIAVGSDADVVIWDPDKLKTI 534

  Fly   425 GPELLYTATKATPYAGQKLRGVVHATVVRGLHVYQQFE-GFGQPLGKVLLRRS 476
            ..:...:|.:...:.|.:..|.....:.:|..|::... ...:.:|:.:.|::
Human   535 TAKSHKSAVEYNIFEGMECHGSPLVVISQGKIVFEDGNINVNKGMGRFIPRKA 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6106	NP_001285403.1	L-HYD_ALN	2..473	CDD:238640	123/503 (24%)
CRMP1	NP_001014809.1	PRK09060	131..581	CDD:181632	121/497 (24%)
CRMP1	NP_001014809.1	D-HYD	131..580	CDD:238639	121/496 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0044
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D719800at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820