DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6106 and Dpysl2

DIOPT Version :9

Sequence 1:	NP_001285403.1	Gene:	CG6106 / 32816	FlyBaseID:	FBgn0030914	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001365696.1	Gene:	Dpysl2 / 12934	MGIID:	1349763	Length:	673	Species:	Mus musculus

Alignment Length:	508	Identity:	125/508 - (24%)
Similarity:	200/508 - (39%)	Gaps:	107/508 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DGSQNALIHGGIIVD-----------TEGIIRRV---LRSPQEVNTYLYNTESESVYDFGDLVLM 64
            |.|...||.||.||:           .:|:|:::   |..|..|.|    .|:.|      .:::
Mouse   113 DQSDRLLIKGGKIVNDDQSFYADIYMEDGLIKQIGENLIVPGGVKT----IEAHS------RMVI 167

  Fly    65 PGLIDPNVHINEP--GRKDWEGFATATKAAAAGGFTTIIDRPTNAQPPTVSVAHLKAKTSTARGK 127
            ||.||.:.....|  |....:.|...||||.|||.|.|||... .:|.|..:|........|..|
Mouse   168 PGGIDVHTRFQMPDQGMTSADDFFQGTKAALAGGTTMIIDHVV-PEPGTSLLAAFDQWREWADSK 231

  Fly   128 ------IYVDVGFWGGLVPGNGDQLAALL-GAGVMGLQCTLCDPAAPVSQEFPAVNESQLEEALS 185
                  ::||:..|.   .|..:::.||: ..||......:.     ....| .:.:||:.|.||
Mouse   232 SCCDYSLHVDITEWH---KGIQEEMEALVKDHGVNSFLVYMA-----FKDRF-QLTDSQIYEVLS 287

  Fly   186 QLDKDQAEGEAIVAVHAELPLTTEIHPDEE---------APREYGTFLVTRPPQMEISATQLLCR 241
            .: :|..   ||..||||   ..:|..:|:         .|..:   :::||.::|..|......
Mouse   288 VI-RDIG---AIAQVHAE---NGDIIAEEQQRILDLGITGPEGH---VLSRPEEVEAEAVNRSIT 342

  Fly   242 LANRHPRRC-IHILNCSSGESLPLVEECRRQG---------GNLTVDTCPHY----LALAAEDVP 292
            :||:  ..| :::....|..:..::.:.|::|         .:|..|. .||    .|.||
Mouse   343 IANQ--TNCPLYVTKVMSKSAAEVIAQARKKGTVVYGEPITASLGTDG-SHYWSKNWAKAA---- 400

  Fly   293 DCGTEFKTWPPIRERRNQEQLWQALRPGGAIRMIGSDHSPATPGARALTCGRGRGNFLKAWPGIN 357
                .|.|.||:...........:|...|.:::.||.|.......:|:    |:.||.....|.|
Mouse   401 ----AFVTSPPLSPDPTTPDFLNSLLSCGDLQVTGSAHCTFNTAQKAV----GKDNFTLIPEGTN 457

  Fly   358 SLQLSLSVVW-TAAANRRGSANLTIADIHRLMCQEPANLCGLSASKGRIAEGYDADFCVWSPEEE 421
            ..:..:||:| .|....:...|..:|    :.....|.:..|...||||:.|.|||..:|.|:..
Mouse   458 GTEERMSVIWDKAVVTGKMDENQFVA----VTSTNAAKVFNLYPRKGRISVGSDADLVIWDPDSV 518

  Fly   422 FTVGPELLYTATKATPYAGQKLRGVVHATVVRG--------LHVYQQFEGFGQ 466
            .|:..:...:|.:...:.|.:.||.....:.:|        |||   .||.|:
Mouse   519 KTISAKTHNSALEYNIFEGMECRGSPLVVISQGKIVLEDGTLHV---TEGSGR 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6106	NP_001285403.1	L-HYD_ALN	2..473	CDD:238640	125/508 (25%)
Dpysl2	NP_001365696.1	D-HYD	118..567	CDD:238639	122/500 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0044
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D719800at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820