DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6106 and dpys

DIOPT Version :9

Sequence 1:	NP_001285403.1	Gene:	CG6106 / 32816	FlyBaseID:	FBgn0030914	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001116535.1	Gene:	dpys / 100144569	ZFINID:	ZDB-GENE-070508-1	Length:	500	Species:	Danio rerio

Alignment Length:	496	Identity:	117/496 - (23%)
Similarity:	200/496 - (40%)	Gaps:	69/496 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LIHGGIIVD-----------TEGIIRRVLRSPQEVNTYLYNTESESVYDFGDLVLMPGLIDPNVH 73
            ||.||.:|:           .:|:|       ..|.|.|.......|.|....:::||.||.:.|
Zfish     8 LIKGGKVVNEDFSVMADVYIEDGVI-------SGVGTDLQVAAGTRVIDATHKLVLPGGIDSHTH 65

  Fly    74 --INEPGRKDWEGFATATKAAAAGGFTTIIDRPTNAQPPTVSVAHLKAKTSTARGKIYVD----- 131
              ::..|....:.|.|.|:||.|||.|.|:|.....:..::..|:.:.: .||..|:..|
Zfish    66 MELSFMGTTTADDFQTGTQAAVAGGTTMILDFVIAQKGCSLLEAYERWR-RTADPKVCCDYSLHM 129

  Fly   132 -VGFWGGLVPGNGDQLAALLGAGVMGLQCTLCDPAAPVSQEFPAVNESQLE-EALSQLDKDQAEG 194
             |.:|...|....:.|.:..|.....:.....|.......|..||..:..| .|::|:   .||.
Zfish   130 AVTWWDDTVKKEMETLVSEKGINSFKMFMAYKDLYMLQDLELYAVFSTCKEIGAIAQV---HAEN 191

  Fly   195 EAIVAVHAELPLTTEIHPDEEAPREYGTFLVTRPPQMEISATQLLCRLANRHPRRC-IHILNCSS 258
            ..::|..|:..|:..|...|...       :.||.::|..|||....:|  |...| :::::..|
Zfish   192 GDLIAEGAKRMLSLGITGPEGHE-------MCRPEEVEAEATQRAITIA--HATNCPLYVVHVMS 247

  Fly   259 GESLPLVEECRRQGGNLTVDTCPHYLALAAEDVPDCGTEF--KTW---------PPIRERRNQEQ 312
            ..:..:|...||.|..:..:  |....|..:     ||.:  :.|         ||:|...:...
Zfish   248 KSAAKVVANARRNGRLVFGE--PIAAGLGTD-----GTHYWHENWAHAAGFVMGPPLRPDPSTPG 305

  Fly   313 LWQALRPGGAIRMIGSDHSPATPGARALTCGRGRGNFLKAWPGINSLQLSLSVVWTAAANR-RGS 376
            ....|.....:.:.|:|:...:...:||    |:.:|.|...|:|.::..:||:|....:. :..
Zfish   306 YLMDLLANDDLSVTGTDNCTFSVCQKAL----GKDDFTKIPNGVNGVEDRMSVIWEKGVHSGKMD 366

  Fly   377 ANLTIADIHRLMCQEPANLCGLSASKGRIAEGYDADFCVWSPEEEFTVGPELLYTATKATPYAGQ 441
            .|..:|    :.....|.:..|...|||||:|.|||..:|.|:....:..:..:.|.....:.|.
Zfish   367 ENRFVA----VTSTNAAKIFNLYPRKGRIAKGSDADLVIWDPKASRVISAKTHHQAVDYNIFEGM 427

  Fly   442 KLRGVVHATVVRGLHVYQQFEGFGQP-LGKVLLRRSSRKLV 481
            ...||...|:.||..||:..:.|.:| .|:.:.|:...:.|
Zfish   428 LCHGVPVVTISRGKVVYENGKLFTKPGEGRYIPRKPFAEFV 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6106	NP_001285403.1	L-HYD_ALN	2..473	CDD:238640	115/486 (24%)
dpys	NP_001116535.1	PRK09060	1..455	CDD:181632	114/481 (24%)
dpys	NP_001116535.1	D-HYD	7..456	CDD:238639	114/482 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0044
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D719800at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820